Projects funded by the NCN
Effects of receptor action of L- and D-Lactate on cervical cancer cells. Lactate modulation of cell DNA repair response after anticancer chemotherapeutics' treatment.
2011/03/B/NZ4/00046
Keywords:
GPR 81 receptor for L-Lactate cervical carcinoma DNA repair
Descriptors:
- NZ4_2: Physiology
- NZ4_4: Pathophysiology
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Instytut Biologii Medycznej PAN
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: OPUS 2 - announced on 2011-09-15
Amount awarded: 434 200 PLN
Project start date (Y-m-d): 2012-09-14
Project end date (Y-m-d): 2015-09-13
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (1)
- L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activationAuthors:Waldemar Wagner, Wojciech M. Ciszewski, Katarzyna D. KaniaAcademic press:Cell Communication and Signaling (rok: 2015, tom: 13, strony: 16), Wydawca: BioMed CentralStatus:PublishedDOI:10.1186/s12964-015-0114-x - link to the publication