Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Determining the significance of a new potential miRNA-based marker in biology and earlier detection of the ovarian carcinoma.

2011/02/A/NZ2/00017

Keywords:

ovarian cancer circulating miRNA plasma germline mutation genes BRCA1 BRCA2 BARD1 RAD51C RAD51D

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_11: Genetic epidemiology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Limon 

Number of co-investigators in the project: 6

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 3 000 000 PLN

Project start date (Y-m-d): 2012-04-30

Project end date (Y-m-d): 2017-12-30

Project duration:: 68 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. analizator genetyczny (sekwenator) MiSeq Illumina.
  2. po-demonstracyjny analizator genetyczny ABI PRISM 3500 (470 000 PLN)
  3. Blok 384 do LightCyclera 480 (30 000 PLN)
  4. oprogramowanie HGMD.
  5. licencja dostępu do bazy ALAMUT.

Information in the final report

  • Publication in academic press/journals (10)
  1. Analysis of large mutations in BARD1 in patients with breast and/or ovarian cancer: the Polish population as an example.
    Authors:
    Klonowska K, Ratajska M, Czubak K, Kuzniacka A, Brozek I, Koczkowska M, Sniadecki M, Debniak J, Wydra D, Balut M, Stukan M, Zmienko A, Nowakowska B, Irminger-Finger I, Limon J, Kozlowski P.
    Academic press:
    Scientific reports (rok: 2015, tom: 5, strony: 10424), Wydawca: Nature group
    Status:
    Published
    DOI:
    10.1038/srep10424. - link to the publication
  2. Detection of BRCA1/2 mutations in circulating tumor DNA from patients with ovarian cancer.
    Authors:
    Ratajska M, Koczkowska M, Żuk M, Gorczyński A, Kuźniacka A, Stukan M, Biernat W, Limon J, Wasąg B
    Academic press:
    Oncotarget (rok: 2017, tom: 8 (60), strony: 101325-101332), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.20722 - link to the publication
  3. Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients.
    Authors:
    Ronowicz A, Janaszak-Jasiecka A, Skokowski J, Madanecki P, Bartoszewski R, Bałut M, Seroczyńska B, Kochan K, Bogdan A, Butkus M, Pęksa R, Ratajska M, Kuźniacka A, Wasąg B, Gucwa M, Krzyżanowski M, Jaśkiewicz J, Jankowski Z, Forsberg L, Ochocka JR, Limon J, Crowley MR, Buckley PG, Messiaen L, Dumanski JP, Piotrowski A.
    Academic press:
    Human Mutation (rok: 2015, tom: 36(11, strony: 1088-1099), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/humu.22845 - link to the publication
  4. Mutational analysis of BRCA1/2 in a group of 134 consecutive ovarian cancer patients. Novel and recurrent BRCA1/2 alterations detected by next generation sequencing
    Authors:
    Magdalena Ratajska, Magdalena Krygier, Maciej Stukan, Alina Kuźniacka, Magdalena Koczkowska, Mirosław Dudziak, Marcin Śniadecki, Jarosław Dębniak, Dariusz Wydra, Izabela Brozek, Wojciech Biernat, Ake Borg, Janusz Limon, Bartosz Wasąg
    Academic press:
    J Appl Genetics (rok: 2014, tom: online, strony: online), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13353-014-0254-5 - link to the publication
  5. A novel splicing mutation in the SLC9A3R1 gene in tumors from ovarian cancer patients.
    Authors:
    Kreimann EL, Ratajska M, Kuzniacka A, Demacopulo B, Stukan M, Limon J.
    Academic press:
    Oncology Letters (rok: 2015, tom: 10(6), strony: 3722-3726), Wydawca: Spandidos publications
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects.
    Authors:
    Wiczling P, EmiliaDaghir-Wojtkowiak E, Kaliszan R, Markuszewski M, Limon J, Koczkowska M, Stukan M,Kuźniacka A, Ratajska M
    Academic press:
    PLOS ONE (rok: 2019, tom: 14(8), strony: e0221764), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0221764 - link to the publication
  7. Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability.
    Authors:
    Pilyugin M, André PA, Ratajska M, Kuzniacka A, Limon J, Tournier BB, Colas J, Laurent G, Irminger-Finger I.
    Academic press:
    Oncotarget (rok: 2017, tom: 8, strony: 9339-9353), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.14068 - link to the publication
  8. Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients
    Authors:
    Koczkowska M, Krawczynska N, Stukan M, Kuzniacka A, Brozek I, Sniadecki M, Debniak J, Wydra D, Biernat W, Kozlowski P, Limon J, Wasag B, Ratajska M
    Academic press:
    Cancers (rok: 2018, tom: 10(11), strony: E442), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers10110442 - link to the publication
  9. Cancer predisposing BARD1 mutations affect exon skipping and are associated with overexpression of specific BARD1 isoforms.
    Authors:
    Ratajska M, Matusiak M, Kuzniacka A, Wasag B, Brozek I, Biernat W, Koczkowska M, Debniak J, Sniadecki M, Kozlowski P, Klonowska K, Pilyugin M, Wydra D, Laurent G, Limon J, Irminger-Finger I.
    Academic press:
    Oncology Reports (rok: 2015, tom: 34(5), strony: 2609-2617), Wydawca: Spandidos publications
    Status:
    Published
    DOI:
    10.3892/or.2015.4235. - link to the publication
  10. Prevalence of the BLM nonsense mutation, p.Q548X, in ovarian cancer patients from Central and Eastern Europe.
    Authors:
    Bogdanova N1, Togo AV, Ratajska M, Kluźniak W, Takhirova Z, Tarp T, Prokofyeva D, Bermisheva M, Yanus GA, Gorodnova TV, Sokolenko AP, Kuźniacka A, Podolak A, Stukan M, Wokołorczyk D, Gronwald J, Vasilevska D, Rudaitis V, Runnebaum IB, Dürst M, Park-Simon TW, Hillemanns P, Antonenkova N, Khusnutdinova E, Limon J, Lubinski J, Cybulski C, Imyanitov E, Dörk T.
    Academic press:
    Fam Cancer. (rok: 2014, tom: online, strony: online), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10689-014-9748-x - link to the publication

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