Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Downregulation of Iron Regulatory Protein 1 expression in oxidative stress: molecular mechanisms, impact on intracellular iron metabolism, importance in the pathogenesis of Amyotropic Lateral Sclerosis

2011/01/B/NZ3/00632

Keywords:

iron metabolism IRP1 IRE superoxide anion oxidative stress SOD ALS

Descriptors:

  • NZ3_2: Cell physiology
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Genetyki i Hodowli Zwierząt PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Paweł Lipiński 

Number of co-investigators in the project: 3

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 352 000 PLN

Project start date (Y-m-d): 2011-12-19

Project end date (Y-m-d): 2015-06-18

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Metabolizm hemu jako integralny element homeostazy żelaza
    Authors:
    Paweł Lipiński, Rafał R. Starzyński, Agnieszka Styś, Anna Gajowiak, Robert Staroń
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2014, tom: 68, strony: 557-570), Wydawca: Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN
    Status:
    Published
  2. A drastic superoxide-dependent oxidative stress is prerequisite for the down-regulation of IRP1: insights from studies on SOD1-deficient mice and macrophages treated with paraquat
    Authors:
    Anna Milczarek, Rafał R.Starzyński, Agnieszka Styś, Aneta Jończy, Robert Staroń, Agnieszka Grzelak, PawełLipiński
    Academic press:
    PloS One , Wydawca: Public Library of Science
    Status:
    Submitted
  3. Mice Overexpressing Both Non-Mutated Human SOD1 and Mutated SOD1G93A Genes: A Competent Experimental Model for Studying Iron Metabolism in Amyotrophic Lateral Sclerosis
    Authors:
    Anna Gajowiak, Agnieszka Styś, Rafał R. Starzyński, Aleksandra Bednarz, Małgorzata Lenartowicz, Robert Staroń and Paweł Lipiński
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2016, tom: 8 (article 82), strony: 45306), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fnmol.2015.00082 - link to the publication
  4. Zaburzenie hoemostazy żelaza w stwardnieniu zanikowym bocznym
    Authors:
    Anna Gajowiak, Agnieszka Styś, Rafał R. Starzyński, Robert Staroń, Paweł Lipiński
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2016, tom: 70, strony: 709-721), Wydawca: Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN
    Status:
    Published
    DOI:
    10.5604/17322693.1208036 - link to the publication
  1. Overexpression of both non-muteted human SOD1 and mutated SOD1G93A genes induces changes of iron metabolism genes in mice
    Authors:
    Anna Gajowiak, Rafał R. Starzyński, Paweł Lipiński, Robert Staroń, Agnieszka Styś
    Conference:
    2nd Meeting of the Polish Iron Club (Ferrum Rex) (rok: 2015, ), Wydawca: Polskie Towarzystwo Anatomicze, Polskie Towarzystwo Biologii Komórki
    Data:
    konferencja 12-13 maja
    Status:
    Published