Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Chosen epigenetic and genetic mechanisms in non-small cell lung carcinoma (NSCLC) development.

2011/01/B/NZ4/04966

Keywords:

non-small cell lung carcinoma genetic factors epigenetic mechanism genetic instability loss of heterozygosity

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_1: Molecular genetics
  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski, Zakład Molekularnych Podstaw Medycyny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Adam Antczak 

Number of co-investigators in the project: 6

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 398 782 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2014-12-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Autoklaw parowy Millenium B.
  2. Termocykler 8800 (36 000 PLN)
  3. Wirówka Centrifuge 5810R, f-my Eppendorf (43 000 PLN)
  4. System do archiwizacji żeli z transiluminatorem CSL-microDOC (ULTRA-COMPACT GEL DOCUMENTATION SYSTEM CSL-microDOC) z drukarką termiczną i kamerą cyfrową, f-my Cleaver Scientific Ltd (Warwickshire, UK) (25 000 PLN)
  5. Bioanalyzer 2100.

Information in the final report

  • Publication in academic press/journals (5)
  1. FHIT promoter methylation status, low protein and high mRNA levels in patients with non-small cell lung cancer
    Authors:
    Karolina H. Czarnecka, Monika Migdalska-Sęk, Daria Domańska, Dorota Pastuszak-Lewandoska, Agata Dutkowska, Jacek Kordiak, Ewa Nawrot, Justyna Kiszałkiewicz, Adam Antczak, Ewa Brzeziańska-Lasota
    Academic press:
    INTERNATIONAL JOURNAL OF ONCOLOGY (rok: 2016, tom: 49, strony: 1175-1184), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3610 - link to the publication
  2. Significant frequency of allelic imbalance in 3p region covering RARb and MLH1 loci seems to be essential in molecular non-small cell lung cancer diagnosis
    Authors:
    Antczak A, Migdalska-Sęk M, Pastuszak-Lewandoska D, Czarnecka K, Nawrot E, Domańska D, Kordiak J, Górski P, Brzeziańska E.
    Academic press:
    Medical Oncology (rok: 2013, tom: 30, strony: 532), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12032-013-0532-9. - link to the publication
  3. Expression level and methylation status of three tumor suppressor genes, DLEC1, ITGA9 and MLH1, located at 3p21.3 in AP20 region in non-small cell lung cancer
    Authors:
    Dorota Pastuszak-Lewandoska, Jacek Kordiak, Adam Antczak, Monika Migdalska-Sęk, Karolina Czarnecka, Paweł Górski, Ewa Nawrot, Justyna Kiszałkiewicz, Daria Domańska, and Ewa Brzeziańska-Lasota
    Academic press:
    Medical Oncology (rok: 2016, tom: 33, strony: 75), Wydawca: Northwood, Middlesex, England : Science and Technology Letters, c1994-2001- : Totowa, NJ : Humana Press Inc.
    Status:
    Published
    DOI:
    10.1007/s12032-016-0791-3 - link to the publication
  4. Quantitative analysis of mRNA expression levels and DNA methylation profiles of FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer recognizes the diagnostic role of RASSF1A
    Authors:
    Dorota Pastuszak-Lewandoska, Jacek Kordiak, Monika Migdalska-Sek, Karolina Czarnecka, Adam Antczak, Pawel Górski, Ewa Nawrot, Justyna Kiszalkiewicz, Daria Domanska and Ewa Brzezianska-Lasota
    Academic press:
    Respiratory Research (rok: 2015, tom: 16, strony: 76), Wydawca: London : Current Science Ltd., c2000-2001-: London : BioMed Central Ltd.
    Status:
    Published
    DOI:
    10.1186/s12931-015-0230-6 - link to the publication
  5. Decreased FAM107A Expression in Patients with Non-Small Cell Lung Cancer
    Authors:
    D. Pastuszak-Lewandoska, K.H. Czarnecka, M. Migdalska-Sęk, E. Nawrot, D. Domańska, J. Kiszałkiewicz, J. Kordiak, A. Antczak, P. Górski, E. Brzeziańska-Lasota
    Academic press:
    Advances in experimental medicine and biology (rok: 2015, tom: 852, strony: 39-48), Wydawca: New York, Plenum Press.
    Status:
    Published
    DOI:
    10.1007/5584_2014_109 - link to the publication

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