Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structural studies of proteases of unknown catalytic type. Establishment of a unique group dedicated to structural studies at the Jagiellonian University and Malopolska Center of Biotechnology

2011/01/D/NZ1/01169

Keywords:

proteases protolytic enzymes mechanism of catalysis structrual studies

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

UNIWERSYTET JAGIELLOŃSKI

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Grzegorz Dubin 

Number of co-investigators in the project: 8

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 996 550 PLN

Project start date (Y-m-d): 2011-12-06

Project end date (Y-m-d): 2015-06-05

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy.
  2. Zestaw pipet (4 500 PLN)
  3. Dewar transportowy CX100. Walizka transportowa do CX100 (8 500 PLN)
  4. Monitor LCD/LED, Notebook (4 500 PLN)
  5. Mikrowirówka z chłodzeniem. Wirnik kątowy. (12 500 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Atomic resolution crystal structure of HV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
    Authors:
    Grudnik, P., Debowski, D., Legowska, A., Malicki, S., Golik, P., Karna, N., Rolka, K., Dubin, G.
    Academic press:
    Proteins (rok: 2015, tom: 83, strony: 582-589), Wydawca: Wiley Periodicals Inc.
    Status:
    Published
    DOI:
    10.1002/prot.24750 - link to the publication
  2. Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus
    Authors:
    Zdzalik, M., Kalinska, M., Wysocka, M., Stec-Niemczyk, J., Cichon, P., Stach, N., Gruba, N., Stennicke, H.R., Jabaiah, A., Markiewicz, M., Kedracka-Krok, S., Wladyka, B., Daugherty, P.S., Lesner, A., Rolka, K., Dubin, A., Potempa, J., Dubin, G.
    Academic press:
    Plos ONE (rok: 2013, tom: 8, strony: e76812), Wydawca: Public Library Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0076812 - link to the publication
  3. Evaluation of P1' substrate specificity of staphylococcal SplB protease
    Authors:
    Katarzyna Pustelny, Natalia Stach, Benedykt Wladyka, Adam Dubin and Grzegorz Dubin
    Academic press:
    Acta Biochimica Polonica (rok: 2014, tom: 61, strony: 149-152), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Structural basis of GD2 ganglioside and mimetic peptide recognition by 14G2a antibody
    Authors:
    Horwacik, I., Golik, P., Grudnik, P., Kolinski, M., Zdzalik, M., Rokita, H., Dubin, G.
    Academic press:
    Molecular and Cellular Proteomics (rok: 2015, tom: 14, strony: 2577-2590), Wydawca: American Society for Biochemisty and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/mcp.M115.052720 - link to the publication
  5. Insights into eukaryotic Rubisco assembly - Crystal structures of RbcX chaperones from Arabidopsis thaliana.
    Authors:
    Kolesinski, P., Golik, P., Grudnik, P., Piechota, J., Markiewicz, M., Tarnawski, M., Dubin, G., Szczepaniak, A.
    Academic press:
    BBA General Subjects (rok: 2013, tom: 1830, strony: 2899-2906), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagen.2012.12.025 - link to the publication
  6. Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation
    Authors:
    Katarzyna Pustelny, Michal Zdzalik, Natalia Stach, Justyna Stec-Niemczyk, Przemyslaw Cichon, Anna Czarna, Grzegorz Popowicz, Pawel Mak, Marcin Drag, Guy S. Salvesen, Benedykt Wladyka, Jan Potempa, Adam Dubin, Grzegorz Dubin
    Academic press:
    Journal of Biological Chemistry (rok: 2014, tom: 289, strony: 15544-15553), Wydawca: The American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M113.507616 - link to the publication
  7. Bacterial proteases in disease - role in intracellular survival, evasion of coagulation/fibrinolysis innate defenses, toxicoses and viral infections.
    Authors:
    Dubin, G., Koziel, J., Pyrc, K., Wladyka, B., Potempa. J.
    Academic press:
    Current Pharmaceutical Design (rok: 2012, tom: 19, strony: 1090-1113), Wydawca: Bentham Science Publishing Ltd.
    Status:
    Published
    DOI:
    brak - link to the publication
  8. Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus
    Authors:
    Ewa Burchacka, Michal Zdzalik, Justyna-Stec Niemczyk, Katarzyna Pustelny, Grzegorz Popowicz, Benedykt Wladyka, Adam Dubin, Jan Potempa, Marcin Sienczyk, Grzegorz Dubin, Jozef Oleksyszyn
    Academic press:
    Protein Science (rok: 2014, tom: 23, strony: 179-189), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/pro.2403 - link to the publication

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