Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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High throughput determination of RNA targets for MBNL1 splicing factor - Implication for myotonic dystrophy

2011/01/B/NZ1/01603

Keywords:

deep sequencing alternative splicing RNA structure myotonic dystrophy CUG repeats MBNL1

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet im. Adama Mickiewicza, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Sobczak 

Number of co-investigators in the project: 7

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 654 380 PLN

Project start date (Y-m-d): 2011-12-21

Project end date (Y-m-d): 2015-06-20

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kuchenka mikrofalowa (500 PLN)
  2. Termoblok do probówek Eppendorf (5 000 PLN)
  3. Termocykler (35 000 PLN)
  4. Zestaw do analizy kwasów nukleinowych (aparaty do elektroforezy z zasilaczami) (17 000 PLN)
  5. Zestaw pipet automatycznych (3 szt.) (5 000 PLN)
  6. Pompa próżniowa (3 500 PLN)
  7. Miniwirówki i worteksy (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Small molecule kinase inhibitors alleviate different molecular features of myotonic dystrophy type 1.
    Authors:
    Wojciechowska M, Taylor K, Sobczak K, Napierala M, Krzyzosiak WJ
    Academic press:
    RNA Biology (rok: 2014, tom: 11, strony: 742-54), Wydawca: Landes Bioscience
    Status:
    Published
    DOI:
    10.4161/rna.28799 - link to the publication
  2. Oral administration of erythromycin reduces RNA toxicity in myotonic dystrophy
    Authors:
    Masayuki Nakamori, Katarzyna Taylor, Hideki Mochizuki, Krzysztof Sobczak, Masanori P. Takahashi
    Academic press:
    Annals of Clinical and Translational Neurology (rok: 2016, tom: 3, strony: 42–54), Wydawca: American Neurological Association
    Status:
    Published
    DOI:
    10.1002/acn3.271 - link to the publication
  3. Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy
    Authors:
    Wojtkowiak-Szlachcic A, Taylor K, Stepniak-Konieczna E, Sznajder LJ, Mykowska A, Sroka J, Thornton CA, Sobczak K
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 3318-3331), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkv163 - link to the publication
  4. Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.
    Authors:
    Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn DJ, Goodwin M, Zhang C, Sobczak K, Thornton CA, Swanson MS.
    Academic press:
    Molecular Cell (rok: 2014, tom: 56, strony: 311-22), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.molcel.2014.08.027 - link to the publication
  5. Mechanistic Determinants of MBNL Activity
    Authors:
    Łukasz J. Sznajder, Michał Michalak, Michał Kabza, Katarzyna Taylor, Piotr Cywoniuk, Agnieszka Wojtkowiak-Szlachcic, Magdalena Matloka, Patryk Konieczny, Krzysztof Sobczak
    Academic press:
    Nucleic Acids Research , Wydawca: Oxford University Press
    Status:
    Submitted
    DOI:
    brak - link to the publication
  6. Dystrofia miotoniczna - patomechanizm molekularny i strategie terapeutyczne
    Authors:
    Arkadiusz Kajdasz, Krzysztof Sobczak
    Academic press:
    Postępy Biologii Komórki (rok: 2016, tom: 43, strony: 27-52), Wydawca: Polskie Towarzystwo Anatomiczne i Polskie Towarzystwo Biologii Komórki
    Status:
    Published
    DOI:
    brak - link to the publication
  7. MBNL proteins and their target RNAs, interaction and splicing regulation.
    Authors:
    Konieczny P, Stepniak-Konieczna E, Sobczak K.
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 10873-87), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku767 - link to the publication
  8. Autoregulation of MBNL1 by binding to its transcript
    Authors:
    Patryk Konieczny, Katarzyna Taylor, Lukasz J. Sznajder and Krzysztof Sobczak
    Academic press:
    Nucleic Acids Research (rok: 2015, ), Wydawca: Oxford University Press
    Status:
    Submitted
    DOI:
    brak - link to the publication

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