Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Thrombotic Mechanisms in Human Cystathionine β-Synthase Deficiency

2011/01/B/NZ1/03417

Keywords:

thrombosis cystathione-β synthase (CBS) deficiency hyperhomocysteinemia protein N-homocysteinylation

Descriptors:

  • NZ1_1:
  • NZ5_3:
  • NZ1_2:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 4

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 813 800 PLN

Project start date (Y-m-d): 2011-12-06

Project end date (Y-m-d): 2014-12-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrofluorymetr Hitachi F700 z termoregulacja (120 000 PLN)
  2. TEG® 5000 Thrombelastograph® Hemostasis Analyzer (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (20)
  • Articles in post-conference publications (18)
  • Book publications / chapters in book publications (2)
  1. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration.
    Authors:
    Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    J Alzheimers Dis. (rok: 2014, tom: 42, strony: 247-260), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132714 - link to the publication
  2. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease.
    Authors:
    Suszyńska-Zajczyk J, Sikora M, Jakubowski H.
    Academic press:
    Mol Genet Metab. (rok: 2014, tom: 113, strony: 200-206), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.07.011 - link to the publication
  3. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease.
    Authors:
    Suszyńska-Zajczyk J, Utyro O, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 112, strony: 339-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.05.010 - link to the publication
  4. Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension.
    Authors:
    Bogdanski P, Miller-Kasprzak E, Pupek-Musialik D, Jablecka A, Lacinski M, Jagodzinski PP, Jakubowski H.
    Academic press:
    Clin Chem Lab Med. (rok: 2012, tom: 50, strony: 1107-13), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/cclm-2011-0856. - link to the publication
  5. Identification of N-homocysteinylation sites in plasma proteins
    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H
    Academic press:
    Amino Acids (rok: 2013, tom: 46(1), strony: 235-44), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 - link to the publication
  6. Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease.
    Authors:
    Suszyńska-Zajczyk J, Utyro O, Jakubowski H.
    Academic press:
    Mol Genet Metab (rok: 2014, tom: 112, strony: 339-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.05.010 - link to the publication
  7. Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration.
    Authors:
    Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H.
    Academic press:
    J Alzheimers Dis. (rok: 2014, tom: 42, strony: 247-260), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-132714 - link to the publication
  8. Identification of N-homocysteinylation sites in plasma proteins
    Authors:
    Sikora M, Marczak Ł, Kubalska J, Graban A, Jakubowski H
    Academic press:
    Amino Acids (rok: 2013, tom: 46(1), strony: 235-44), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-013-1617-7 - link to the publication
  9. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H
    Academic press:
    J Alzheimer's Dis (rok: 2014, tom: -, strony: -), Wydawca: IOS Press
    Status:
    Published
    DOI:
    brak - link to the publication
  10. Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
    Authors:
    Suszyńska-Zajczyk J, Wróblewski J, Utyro O, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2013, tom: -, strony: -), Wydawca: Springer
    Status:
    Published
  11. The mechanism and consequences of homocysteine incorporation into protein in humans
    Authors:
    Jakubowski H
    Academic press:
    Phosphorus, Sulfur, and Silicon and the Related Elements (rok: 2013, tom: 188, strony: 384-395), Wydawca: Taylor & Francis
    Status:
    Published
  12. Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease.
    Authors:
    Suszyńska-Zajczyk J, Sikora M, Jakubowski H.
    Academic press:
    Mol Genet Metab. (rok: 2014, tom: 113, strony: 200-206), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2014.07.011 - link to the publication
  13. Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase
    Authors:
    Borowczyk K, Tisończyk J, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2012, tom: 43, strony: 1339-48), Wydawca: springer
    Status:
    Published
    DOI:
    10.1007/s00726-011-1207-5. - link to the publication
  14. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1.
    Authors:
    Borowczyk K, Shih DM, Jakubowski H.
    Academic press:
    J Alzheimers Dis. (rok: 2012, tom: 30, strony: 225-31), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-2012-111940. - link to the publication
  15. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1.
    Authors:
    Borowczyk K, Shih DM, Jakubowski H.
    Academic press:
    J Alzheimers Dis. (rok: 2012, tom: 30, strony: 225-31), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-2012-111940. - link to the publication
  16. Paraoxonase 1 and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis.
    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Acta Biochim Pol (rok: 2014, tom: 61(4), strony: 815-23), Wydawca: Acta Biochimica Polonica
    Status:
    Published
    DOI:
    link to the publication
  17. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Suszyńska-Zajczyk J, Łuczak M, Marczak Ł, Jakubowski H
    Academic press:
    J Alzheimer's Dis (rok: 2014, tom: -, strony: -), Wydawca: IOS Press
    Status:
    Published
  18. Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension.
    Authors:
    Bogdanski P, Miller-Kasprzak E, Pupek-Musialik D, Jablecka A, Lacinski M, Jagodzinski PP, Jakubowski H.
    Academic press:
    Clin Chem Lab Med. (rok: 2012, tom: 50, strony: 1107-13), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/cclm-2011-0856. - link to the publication
  19. Paraoxonase 1 and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis.
    Authors:
    Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Acta Biochim Pol (rok: 2014, tom: 61(4), strony: 815-23), Wydawca: Acta Biochimica Polonica
    Status:
    Published
    DOI:
    brak - link to the publication
  20. Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis
    Authors:
    Suszyńska-Zajczyk J, Wróblewski J, Utyro O, Łuczak M, Marczak Ł, Jakubowski H.
    Academic press:
    Amino Acids (rok: 2013, tom: -, strony: -), Wydawca: Springer
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Joanna Suszyńska-Zajczyk, Magdalena Łuczak, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  2. Identification of 2-pyridoxyl-1,3-thiazolidine-4-carboxylic acid, novel metabolite of vitamin B6 and cysteine in human plasma
    Authors:
    Rafał Głowacki, Monika Wyszczelska-Rokiel, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  3. Cystathionine-β synthase deficiency changes expression of major urinary proteins in mice
    Authors:
    Jacek Wróblewski, Joanna Perła-Kaján, Monika Wyszczelska-Rokiel, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochmica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  4. N-homocysteinylation as a mechanism of connective tissue impairment in hyperhomocysteinemia due to cystathionine β-synthase deficiency
    Authors:
    Joanna Perła-Kajan, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochmica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  5. Histones are targeted for N-homocysteinylation in human endothelial cells
    Authors:
    Dorota Gurda, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochmica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  6. Identification of specific N-homocysteinylated lysine residues in human plasma albumin and fibrinogen from cystathionine β-synthase-deficient patient
    Authors:
    Marta Sikora, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  7. Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Joanna Suszyńska-Zajczyk, Magdalena Łuczak, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  8. Properties of fibrin clots formed from plasma of cystathionine β-synthase-deficient patients and their unaffected family members
    Authors:
    Izabela Bielińska, Marta Sikora, Joanna Perła-Kajan, Michał Ząbczyk, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  9. Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Joanna Suszyńska-Zajczyk, Magdalena Łuczak, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  10. Properties of fibrin clots formed from plasma of cystathionine β-synthase-deficient patients and their unaffected family members
    Authors:
    Izabela Bielińska, Marta Sikora, Joanna Perła-Kajan, Michał Ząbczyk, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  11. Inactivation of the bleomycin hydrolase (Blmh) gene affects the expression of glyoxalase domain-containing protein 4 (Glod4) gene in mice
    Authors:
    Olga Utyro, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  12. Cystathionine-β synthase deficiency changes expression of major urinary proteins in mice
    Authors:
    Jacek Wróblewski, Joanna Perła-Kaján, Monika Wyszczelska-Rokiel, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochmica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  13. Inactivation of the bleomycin hydrolase (Blmh) gene affects the expression of glyoxalase domain-containing protein 4 (Glod4) gene in mice
    Authors:
    Olga Utyro, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  14. Histones are targeted for N-homocysteinylation in human endothelial cells
    Authors:
    Dorota Gurda, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochmica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  15. Identification of specific N-homocysteinylated lysine residues in human plasma albumin and fibrinogen from cystathionine β-synthase-deficient patient
    Authors:
    Marta Sikora, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  16. Identification of 2-pyridoxyl-1,3-thiazolidine-4-carboxylic acid, novel metabolite of vitamin B6 and cysteine in human plasma
    Authors:
    Rafał Głowacki, Monika Wyszczelska-Rokiel, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  17. N-homocysteinylation as a mechanism of connective tissue impairment in hyperhomocysteinemia due to cystathionine β-synthase deficiency
    Authors:
    Joanna Perła-Kajan, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochmica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  18. Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration
    Authors:
    Joanna Suszyńska-Zajczyk, Magdalena Łuczak, Łukasz Marczak, Hieronim Jakubowski
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics "BIO 2014" Warsaw 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09
    Status:
    Published
    DOI:
    link to the publication
  1. Homocysteine in Protein Structure/Function and Human Disease - Chemical Biology of Homocysteine-containing Proteins
    Authors:
    Hieronim Jakubowski
    Book:
    Homocysteine in Protein Structure/Function and Human Disease - Chemical Biology of Homocysteine-containing Proteins (rok: 2013, tom: 1, strony: XIII, 166 p. 49 illus., 9 illus. in color.), Wydawca: Springer
    Status:
    Published
    DOI:
    link to the publication
  2. Transfer RNA Synthetase Editing of Errors in Amino Acids
    Authors:
    Hieronim Jakubowski
    Book:
    Status:
    Accepted for publication

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