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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of stearoyl-CoA desaturase in pathogenesis of myocardial hypertrophy

2011/01/D/NZ3/04777

Keywords:

lipotoxicity heart hypertension fatty acids

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_2: Cell physiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Paweł Dobrzyń 

Number of co-investigators in the project: 6

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 600 000 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2015-06-06

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw do elektroforezy pionowej, poziomej oraz do transferu białek (25 000 PLN)
  2. Wirówka z chłodzeniem oraz zestawem rotorów (25 000 PLN)
  3. Mikroskop odwrócony.
  4. Termocykler (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (9)
  • Book publications / chapters in book publications (1)
  1. Expression of lipogenic genes is upregulated in the heart with exercise training-induced but not pressure overload-induced left ventricular hypertrophy
    Authors:
    Paweł Dobrzyń, Aleksandra Pyrkowska, Monika Duda, Tomasz Bednarski, Michał Maczewski, Józef Langfort, Agnieszka Dobrzyń
    Academic press:
    American Journal of Physiology - Endocrinology and Metabolism (rok: 2013, tom: 304, strony: E1384-E1358), Wydawca: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpendo.00603.2012 - link to the publication
  2. Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes
    Authors:
    Małgorzata Małodobra-Mazur, Anna Dziewulaska, Kamil Koziński, Paweł Dobrzyń, Katarzyna Kolczyńska, Justyna Janikiewicz, Agnieszka Dobrzyń
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2014, tom: 55, strony: 40-50), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2014.08.005 - link to the publication
  3. Białkowe czynniki lipogenne – rola w regulacji metabolizmu i funkcji mięśnia sercowego
    Authors:
    Tomasz Bednarski, Aleksandra Pyrkowska, Agnieszka Opasińska, Paweł Dobrzyń
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2015, tom: nieznany, strony: nieznane), Wydawca: Index Copernicus International
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  4. Metabolic reprogramming of the heart through stearoyl-CoA desaturase
    Authors:
    Paweł Dobrzyń, Tomasz Bednarski, Agnieszka Dobrzyń
    Academic press:
    Progress in Lipid Research (rok: 2015, tom: 57, strony: 45303), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.plipres.2014.11.003 - link to the publication
  5. Rola desaturazy staroilo-CoA w utrzymaniu homeostazy metabolicznej
    Authors:
    Paweł Dobrzyń
    Academic press:
    Postępy Biochemii (rok: 2012, tom: 58, strony: 166-174), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Cardiac lipid metabolism – the role of stearoyl-CoA desaturase-4
    Authors:
    Anna Ochałek, Paweł Dobrzyń
    Conference:
    1st Nencki Institute PhD Student Conference (rok: 2013, ), Wydawca: Instytut Biologii Doświadczalnej PAN
    Data:
    konferencja 16-18 październik
    Status:
    Published
    DOI:
    link to the publication
  2. Hypertension-induced heart steatosis is not associated with increased cardiac lipogenesis
    Authors:
    Tomasz Bednarski, Adam Olichwier, Agnieszka Opasińska, Paweł Dobrzyń
    Conference:
    BIO 2014 (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 9-12 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  3. Lipid-induced cardiac remodeling and left ventricle steatosis depend on the degree of saturation of fatty acids in dietary fats
    Authors:
    Paweł Dobrzyń, Tomasz Bednarski, Agnieszka Dobrzyń, Monika Duda, Aleksandra Pyrkowska
    Conference:
    The 11th Biennial International Society for the Study of Fatty Acids and Lipids Congress 2014 (rok: 2014, ), Wydawca: International Society for the Study of Fatty Acods and Lipids
    Data:
    konferencja 28 czerwiec - 2 lipiec
    Status:
    Published
    DOI:
    link to the publication
  4. Lipid metabolizm in different types of left ventricular hypertrophy
    Authors:
    Tomasz Bednarski, Aleksandra Pyrkowska, Anna Ochałek, Monika Duda, Agnieszka Dobrzyń, Józef Langfort, Paweł Dobrzyń
    Conference:
    54th International Conference on the Bioscience of Lipids (rok: 2013, ), Wydawca: International Conference on the Bioscience of Lipids
    Data:
    konferencja 17-21 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  5. Overexpression of lipogenic genes in the heart didtinguishes physiologic from pathologic left ventricle hypertrophy
    Authors:
    Paweł Dobrzyń, Aleksandra Pyrkowska, Monika Duda, Michał Maczewski, Tomasz Bednarski, Józef Langfort, Agnieszka Dobrzyń
    Conference:
    Experimental Biology (rok: 2013, ), Wydawca: Federation of American Societies for Experimental Biology
    Data:
    konferencja 20-24 kwiecień
    Status:
    Published
    DOI:
    link to the publication
  6. Stearoyl-CoA desaturase expression is upregulated in exercise training-induced left ventricular hypertrophy
    Authors:
    Paweł Dobrzyń, Aleksandra Pyrkowska, Tomasz Bednarski, Anna Ochałek, Monika Duda, Józef Langfort, Agnieszka Dobrzyń
    Conference:
    38th FEBS Congress (rok: 2013, ), Wydawca: The Federation of European Biochemical Societies
    Data:
    konferencja 6-11 lipiec 2013
    Status:
    Published
    DOI:
    link to the publication
  7. Activity of AMPK/mTOR pathway depends on type and time of hypertensive stimuli in the heart
    Authors:
    Tomasz Bednarski, Monika Duda, Paweł Dobrzyń
    Conference:
    40th FEBS Congress (rok: 2015, ), Wydawca: The Federation of European Biochemical Societes
    Data:
    konferencja 4-9 lipiec
    Status:
    Published
    DOI:
    link to the publication
  8. Effect of dietary stearate and oleate on expression of fatty acid desaturases and elongases in the heart
    Authors:
    T. Bednarski, M. Jazurek, A. Dobrzyń, M. Małodobra-Mazur, P. Dobrzyń
    Conference:
    10th Euro Fed Lipid Congress, Kraków 2012 (rok: 2012, ), Wydawca: 10th Euro Fed Lipid Congress
    Data:
    konferencja 23-26 wrzesień
    Status:
    Published
  9. Monounsaturated fatty acids activate lipogenic pathways in the heart leading to cardiac steatosis and left ventricular remodeling
    Authors:
    Tomasz Bednarski, Aleksandra Pyrkowska, Agnieszka Dobrzyń, Monika Duda, Paweł Dobrzyń
    Conference:
    48th Annual Scientific Meeting of European Society for Clinical Investigation (rok: 2014, ), Wydawca: European Society for Clinical Investigation
    Data:
    konferencja 30 kwiecień - 3 maj
    Status:
    Published
    DOI:
    link to the publication
  1. Stearoyl-CoA desaturase in the control of heart metabolism
    Authors:
    Paweł Dobrzyń, Agnieszka Dobrzyń
    Book:
    Stearoyl-CoA desaturase genes in lipid metabolism (rok: 2013, tom: nie dotyczy, strony: 85-101), Wydawca: Springer
    Status:
    Published
    DOI:
    link to the publication

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