Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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VDAC channel as a target of huntingtin in the etiology of Huntington's disease

2011/01/B/NZ3/00359

Keywords:

mitochondria VDAC channel Huntington's disease yeast model

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet im. Adama Mickiewicza, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hanna Kmita 

Number of co-investigators in the project: 7

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 377 500 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2015-12-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termomikser z funkcją grzania, chłodzenia i mieszania typu comfort (Eppendorf) (13 000 PLN)
  2. Zestaw do elektroforezy i transferu półsuchego: aparat do elektroforezy (MEDIUM) i transferu półsuchego (Sedryt Large) - Kucharczyk/ ZAKUP PRZESUNIĘTO NA 2013 (9 000 PLN)
  3. Mikrowirówka z chłodzeniem MPW65R (14 000 PLN)
  4. System oksygraficzny z dwoma elektrodami tlenowymi (Hansatech) i komputer (23 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (10)
  1. VDAC as a potential target in Huntington's disease therapy: the state of the art.
    Authors:
    Andonis Karachitos, Daria Grobys, Hanna Kmita
    Academic press:
    Pharmaceutical Regulatory Affairs: Open Access (rok: 2015, tom: 4, strony: 157), Wydawca: Omics Publishing/Pharma Group
    Status:
    Published
    DOI:
    10.4172/2167-7689.1000157 - link to the publication
  2. Effect of plant extracts antioxidative phenolic compounds on energetic status and viability of Saccharomyces cerevisiae cells undergoing the oxidative stress
    Authors:
    Justyna Chanaj-Kaczmarek, Michał Wysocki, Andonis Karachitos, Małgorzata Wojcińska, Grzegorz Bartosz, Irena Matławska, Hanna Kmita
    Academic press:
    Journal of Functional Foods (rok: 2015, tom: 16, strony: 364-377), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jff.2015.04.046 - link to the publication
  3. Wild type and mutant huntingtin differently affect status of mitochondrial coupling in intact cells of PC12 model for Huntington's disease
    Authors:
    Klaudia Kulczyńska, Andonis Karachitos, Marta Kuś, Krzysztof Sobczak, Hanna Kmita
    Academic press:
    Journal of Neuroscience Research (rok: 2016, ), Wydawca: Wiley Online Library
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Human VDAC isoforms differ in their capability to interact with minocycline and to contribute to its cytoprotective activity
    Authors:
    Andonis Karachitos, Daria Grobys, Monika Antoniewicz, Sylwia Jedut, Joaquin Jordan, Hanna Kmita
    Academic press:
    Mitochondrion (rok: 2015, ), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Changes of mitochondrial functional states in rat tissue culture model of Huntington's disease triggered by native and mutated version of huntingtin.
    Authors:
    Kulczyńska K, Grobys D., Karachitos A., Kmita H.
    Conference:
    III Konferencja Naukowo-Dydaktyczna Wydziału Biologii UAM (rok: 2014, ), Wydawca: wydawnictwo Kontekst
    Data:
    konferencja 10-12 kwiecień
    Status:
    Published
  2. Effects of cell metabolic state, cell division activity and inhibition of mitochondrial fission on expression of native and mutant version of huntingtin in rat tissue culture model of Huntington's disease.
    Authors:
    Grobys D., Skrzypczak T., Karachitos A., Kmita H
    Conference:
    III Konferencja Naukowo-Dydaktyczna Wydziału Biologii UAM (rok: 2014, ), Wydawca: wydawnictwo Kontekst
    Data:
    konferencja 10-12 kwiecień
    Status:
    Published
  3. Effects of cell division activity, mitochondrial energy status and inhibition of mitochondrial fission on cell viability and distribution of native and mutant version of huntingtin in rat tissue culture model of Huntington's disease (PC12 cells).
    Authors:
    Grobys D., Karachitos A., Skrzypczak T., Kmita H
    Conference:
    18th European Bioenergetics Conference (EBEC) (rok: 2014, ), Wydawca: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Elsevier
    Data:
    konferencja 12 - 17 lipiec
    Status:
    Published
    DOI:
    link to the publication
  4. The therapeutic potential of voltage dependent anionselective channel: implications for Huntington disease. Wykład
    Authors:
    Karachitos A., Grobys D., Zając G., Sobcza K., de Pinto V., Kmita H
    Conference:
    48th Congress of the Polish Biochemical Society (rok: 2013, ), Wydawca: Acta Biochem. Pol. Suppl. 1, 2013
    Data:
    konferencja 2-5 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  5. The yeast model of Huntingtin disease in studies concerning the role of human VDAC isoforms in the disease pathomechanism
    Authors:
    D. Grobys, A. Karachitos, H. Kmita
    Conference:
    40th FEBS Congress - The biochemical basis of life (rok: 2015, ), Wydawca: Wiley Online Library
    Data:
    konferencja 4 - 9 lipiec
    Status:
    Published
    DOI:
    link to the publication
  6. Do native and mutated forms of huntingtin distinguish human VDAC isoforms?
    Authors:
    Karachitos A., Stobienia O., Sobczak K., De Pinto V., Kmita H.
    Conference:
    18th European Bioenergetics Conference (EBEC) (rok: 2014, ), Wydawca: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Elsevier
    Data:
    konferencja 12 - 17 lipiec
    Status:
    Published
    DOI:
    link to the publication
  7. Cell viability and distribution of huntingtin in PC12 model of Huntington disease under conditions affecting cell division, mitochondrial bioenergetics and mitochondrial dynamics.
    Authors:
    Grobys D., Karachitos A., Skrzypczak T., Kmita H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9 - 12 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  8. Do native and mutated forms of huntingtin interact with human VDAC isoforms? Wykład
    Authors:
    Karachitos A., Grobys D., Stobienia O., Sobczak K., De Pinto V., Kmita H.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9 - 12 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  9. Measurements of VDAC conductance in the presence of huntingtin proteins.
    Authors:
    Karachitos A., Stobienia O., Sobczak K., De Pinto V., Kmita H
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9 - 12 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  10. VDAC activity in the presence of huntingtin proteins
    Authors:
    A. Karachitos, D. Grobys, V. De Pinto, H. Kmita
    Conference:
    40th FEBS Congress - The biochemical basis of life (rok: 2015, ), Wydawca: Wiley Online Library
    Data:
    konferencja 4 - 9 lipiec
    Status:
    Published
    DOI:
    link to the publication

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