Projects funded by the NCN

Selected antidepressants toxicity assessment based on in vitro studies of rat spermatocytes and mouse cell lines.

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Przemysław Paweł Sołek

Uniwersytet Rzeszowski, Wydział Biotechnologii

Molecular mechanism of action of antidepressant drugs in the in vitro model of contact allergy in the human cell line Ha...

Call: PRELUDIUM 7 , Panel: NZ6

Principal investigator: Katarzyna Curzytek

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Involvement of cyclooxygenase 2 in antidepressant-like effects of metabotropic glutamatergic receptors group I.

Call: SONATA 7 , Panel: NZ7

Principal investigator: dr Katarzyna Małgorzata Stachowicz

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment: study on the novel genet...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr Grzegorz Kreiner

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rap...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Synthesis, physicochemical and pharmacological properties of new amide derivatives of 3,3-disubstituted pyrrolidine-2,5-...

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Jolanta Maria Obniska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Synthesis of pyridopyrimidine derivatives, dual affinity ligands for 5-HT1AR and SERT.

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Franciszek Herold

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as potential antidepressant agents.

Call: OPUS 5 , Panel: NZ7

Principal investigator: dr Andrzej Józef Chodkowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

The role of chemokines in the pathogenesis of depression and molecular mechanism of action of antidepressants.

Call: OPUS 5 , Panel: NZ7

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The effect of imipramine and risperidone on regulation of the chronic mild stress-induced anhedonia and memory impairmen...

Call: OPUS 5 , Panel: NZ7

Principal investigator: Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Transcription factor MeCP2 as an intracellular object of study on the mechanism of depression and as a potential pharmac...

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Jolanta Sowa-Kućma

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Obtaining of new quinoline derivatives with potential activity for serotonin receptors and inhibition of serotonin reupt...

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Przemysław Paweł Taciak

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Involvement of 5-HT1A receptor signal pathway in the antidepressant effect of zinc

Call: HARMONIA 4 , Panel: NZ7

Principal investigator: dr Bernadeta Szewczyk

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Research on influence of antidepressant drugs on serum and brain levels of neurotrophins in rats, affected by the time d...

Call: OPUS 4 , Panel: NZ4

Principal investigator: dr Maciej Sławomir Kuśmider

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Maciej Henryk Pawłowski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Electrochemical detection of phycotropic substances based on DNA intercalation

Call: PRELUDIUM 4 , Panel: ST4

Principal investigator: dr Joanna Maria Jankowska-Śliwińska

Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk

The role of CRH-BP protein in the regulation of the hypothalamic-pituitary-adrenal axis after antidepressant drugs treat...

Call: OPUS 3 , Panel: NZ4

Principal investigator: dr Joanna Solich

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Role of the endocannabionoid system in the pathogenesis of depression and in the mechanism of action of antidepressant d...

Call: OPUS 3 , Panel: NZ7

Principal investigator: prof. Małgorzata Maria Filip

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr hab. Paweł Maria Zajdel

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Modulation of 5-HT7 receptor signaling as common mechanism involved in the long-lasting antidepressant effects of typica...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Barbara Wanda Chruścicka-Smaga

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Agata Faron-Górecka

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Dual Se-containing 5-HT1A and 5-HT7 biased agonists activating sigma-1 receptor as a hope of finding fast-acting antidep...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Karolina Anna Pytka

Uniwersytet Jagielloński

Anti-neuroinflammatory and antidepressant activities of mycelial in vitro cultures of selected edible mushrooms enriched...

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Jan Patryk Lazur

Uniwersytet Jagielloński

Evaluation of the relationship between doxorubicin resistance, epithelial-mesenchymal plasticity, and effects of selecte...

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Dominika Kunachowicz

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Optogenetic and chemogenetic identification of brain circuits and cellular mechanisms underlying antidepressants resista...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The cross-talk between 5-HTR2A and mGluR2 as a window for antidepressant effects of psilocybin.

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of GPR39 receptor in the mechanism of antidepressant action

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr Katarzyna Młyniec

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Enhancement of antidepressant therapy by combined administration of hyperforin and ketamine: behavioral and molecular st...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Bartłomiej Pochwat

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of the immune checkpoints in the pathomechanism of depressive disorders.

Call: OPUS 22 , Panel: NZ6

Principal investigator: prof. Marta Wanda Kubera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

3D printing as a tool to obtain transdermal microneedle systems with improved efficiency in the treatment of depressive ...

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: prof. Tomasz Zbigniew Osmałek

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The influence of microplastics on the toxicity and fate of selected antidepressants

Call: OPUS 18 , Panel: NZ8

Principal investigator: prof. Grzegorz Leszek Nałęcz-Jawecki

Warszawski Uniwersytet Medyczny

Dual action of HBK-15 – unraveling cellular mechanisms underlying its fast antidepressant-like and procognitive effects...

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Karolina Anna Pytka

Uniwersytet Jagielloński, Collegium Medicum

Novel pharmacological strategies for the treatment of depression

Call: OPUS 16 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Młyniec

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

The role of selected metabotropic glutamate receptors in the mechanism of rapid antidepressant effect of RS-ketamine and...

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Anilide derivatives of long-chain cyclic amines as multifunctional serotonin receptors ligands and phosphodiesterase 7 i...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: dr Agnieszka Wioleta Jankowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial p...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Role of oxidative stress and ceramide in the pathogenesis of depression and in the mechanizm of action of antidepressant...

Call: PRELUDIUM 12 , Panel: NZ5

Principal investigator: Justyna Józefa Brodowicz

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Evaluation of interactions of aripiprazole, the atypical amtipsychotic drug, with the selected antidepressants in the ra...

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Zofia Maria Rogóż

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Modeling of quantitative structure-metabolic stability relationships as a tool to improve design of potential novel anti...

Call: OPUS 12 , Panel: NZ7

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Effect of modulation of the GPR39 zinc receptor on glutamatergic and gabaergic transmission in the context of antidepres...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Gabriela Joanna Starowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

The importance of interaction between NMDA and AMPA receptors and scaffolding proteins in the excitatory synaptic in the...

Call: OPUS 11 , Panel: NZ7

Principal investigator: dr hab. Magdalena Jolanta Sowa-Kućma

Uniwersytet Rzeszowski, Kolegium Nauk Medycznych

The effect of the metabotropic glutamatergic receptor ligands on potentiating the antidepressant-like actvity of scopola...

Call: PRELUDIUM 10 , Panel: NZ7

Principal investigator: Karolina Sylwia Podkowa

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of inflammation, oxidative and nitrosative stress, tryptophan catabolites pathway and DNA base excision repair ...

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Functional dissection of three alpha(1)-adrenergic receptor subtypes in the effects of antidepressant drugs: exploitatio...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Irena Maria Nalepa

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resist...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The application of a modern chromatographic platform with biodetection: HPLC-DAD/MAO A/ESI-TOF-MS in the antidepressant ...

Call: SONATA 9 , Panel: NZ7

Principal investigator: dr hab. Wirginia Anna Kukuła-Koch

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Role of the NLRP3 inflammasome in the mechanisms of action of antidepressant drugs - study in an animal model of depress...

Call: PRELUDIUM 9 , Panel: NZ7

Principal investigator: dr Ewa Izabela Trojan

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk