Projects funded by the NCN

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Searching for natural bioactive farnesoid X receptor agonists and their role in parenteral nutrition-associated liver disease - in silico, in vitro, and in vivo studies

2022/45/B/NZ7/01056

Keywords:

farnesoid X receptor parenteral nutrition liver disease cholestasis natural bioactive compounds

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maciej Jan Stawny 

Number of co-investigators in the project: 9

Call: OPUS 23 - announced on 2022-03-28

Amount awarded: 3 985 130 PLN

Project start date (Y-m-d): 2023-01-10

Project end date (Y-m-d): 2027-01-09

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Natural bioactive compounds–The promising candidates for the treatment of intestinal failure-associated liver disease
    Authors:
    Gostyńska Aleksandra, Buzun Kamila, Żółnowska Izabela, Krajka-Kuźniak Violetta, Mańkowska-Wierzbicka Dorota, Jelińska Anna, Stawny Maciej
    Academic press:
    Clinical Nutrition (rok: 2024, tom: 43, strony: 1952-1971), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.clnu.2024.07.004 - link to the publication
  2. The Development of Magnolol-Loaded Intravenous Emulsion with Low Hepatotoxic Potential
    Authors:
    Aleksandra Gostyńska, Joanna Czerniel, Joanna Kuźmińnska, Izabela Żółnowska, Jakub Brzozowski, Violetta Krajka-Kuźniak, Maciej Stawny
    Academic press:
    Pharmaceuticals (rok: 2023, tom: 16, strony: 1262), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16091262 - link to the publication
  3. The Development of Magnolol-Loaded Intravenous Emulsion with Low Hepatotoxic Potential
    Authors:
    Aleksandra Gostyńska, Joanna Czerniel, Joanna Kuźmińnska, Izabela Żółnowska, Jakub Brzozowski, Violetta Krajka-Kuźniak, Maciej Stawny
    Academic press:
    Pharmaceuticals (rok: 2023, tom: 16, strony: 1262), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16091262 - link to the publication
  4. The anticancer application of delivery systems for honokiol and magnolol
    Authors:
    Dominiak Katarzyna, Gostyńska Aleksandra, Szulc Michał, Stawny Maciej
    Academic press:
    Cancers (rok: 2024, tom: 16, strony: 2257), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers16122257 - link to the publication
  5. Activation of Nrf2 and FXR via natural compounds in liver inflammatory disease
    Authors:
    Belka Marta, Gostyńska-Stawna Aleksandra, Stawny Maciej, Krajka-Kuźniak Violetta
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 11213), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252011213 - link to the publication

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