Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Elucidating neurodegenerative processes using direct profiling of selectively vulnerable neurons

2021/43/D/NZ3/03006

Keywords:

neurodegeneration selective neuronal vulnerability spinocerebellar ataxia single nucleus sequencing targeted profiling transcriptomic atlas of degenerating neurons

Descriptors:

  • NZ3_005:
  • NZ1_001:
  • NZ3_006:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paweł Michał Świtoński 

Number of co-investigators in the project: 2

Call: SONATA 17 - announced on 2021-09-15

Amount awarded: 1 470 600 PLN

Project start date (Y-m-d): 2022-09-01

Project end date (Y-m-d): 2025-08-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients
    Authors:
    Bartelt LC, Switonski PM, Adamek G, Longo F, Carvalho J, Duvick LA, Jarrah SI, McLoughlin HS, Scoles DR, Pulst SM, Orr HT, Hull C, Lowe CB, La Spada AR.
    Academic press:
    Science Translational Medicine (rok: 2024, tom: Vol 16, Issue 772, strony: 45667), Wydawca: American Association for the Advancement of Science (AAAS)
    Status:
    Published
    DOI:
    10.1126/scitranslmed.adn5449 - link to the publication
  2. Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue
    Authors:
    Bartelt LC, Fakhri M, Adamek G, Trybus M, Samelak-Czajka A, Jackowiak P, Fiszer A, Lowe CB, La Spada AR, Switonski PM.
    Academic press:
    Cell Reports Methods (rok: 2024, tom: Volume 4, Issue 7, strony: 100816), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.crmeth.2024.100816 - link to the publication

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