Projects funded by the NCN
Dendritic nanoparticles to enhance the antibacterial properties of phage-derived endolysin against gram-negative bacteria. Assessment of antibacterial properties.
2021/43/D/NZ6/00560
Keywords:
Dendritic nanoparticles phage-derived endolysin outer bacteria membrane antibacterial properties permeabilization
Descriptors:
- NZ6_004:
- ST5_010:
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
Uniwersytet Jana Kochanowskiego w Kielcach, Wydział Nauk Ścisłych i Przyrodniczych
woj. świętokrzyskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: SONATA 17 - announced on 2021-09-15
Amount awarded: 731 719 PLN
Project start date (Y-m-d): 2022-07-15
Project end date (Y-m-d): 2025-07-14
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Molecular mechanism of action of imidazolium carbosilane dendrimers on the outer bacterial membrane – From membrane damage to permeability to antimicrobial endolysinAuthors:Kinga Skrzyniarz, Samuel Takvor-Mena, Karolina Lach, Małgorzata Łysek-Gładysińska, Óscar Barrios-Gumiel, Jesús Cano, Karol CiepluchAcademic press:Journal of Colloid And Interface Science (rok: 2024, tom: 665, strony: 814-824), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.jcis.2024.03.130 - link to the publication
- International Journal of Biological Macromolecules 278 (2024) 134634 Available online 10 August 2024 0141-8130/© 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Endolysin CHAP domain-carbosilane metallodendrimer complexes with triple action on Gram-negative bacteria: Membrane destabilization, reactive oxygen species production and peptidoglycan degradationAuthors:Karolina Lach, Kinga Skrzyniarz, Samuel Takvor-Mena, Małgorzata Łysek-Gładysińska, Piotr Furmańczyk, Oscar Barrios-Gumiel, Javier Sanchez-Nieves, Karol Ciepluch,Academic press:International Journal of Biological Macromolecules (rok: 2024, tom: 278, strony: 134634), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ijbiomac.2024.134634 - link to the publication