Dendritic nanoparticles to enhance the antibacterial properties of phage-derived endolysin against gram-negative bacteria. Assessment of antibacterial properties.
2021/43/D/NZ6/00560
Keywords
Descriptors
- NZ6_004: Bakteriologia
- ST5_010: Materiały /nanomateriały funkcjonalne, nanocząstki
Panel
NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution
Uniwersytet Jana Kochanowskiego w Kielcach, Wydział Nauk Ścisłych i Przyrodniczych
Voivodeship: świętokrzyskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
SONATA 17 – announced on 2021-09-15
- Amount awarded
- 731 719 PLN
- Project start date
- 2022-07-15
- Project end date
- 2025-12-14
- Project duration
- 41 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (2)
-
International Journal of Biological Macromolecules 278 (2024) 134634 Available online 10 August 2024 0141-8130/© 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Endolysin CHAP domain-carbosilane metallodendrimer complexes with triple action on Gram-negative bacteria: Membrane destabilization, reactive oxygen species production and peptidoglycan degradation
- Authors:
- Karolina Lach, Kinga Skrzyniarz, Samuel Takvor-Mena, Małgorzata Łysek-Gładysińska, Piotr Furmańczyk, Oscar Barrios-Gumiel, Javier Sanchez-Nieves, Karol Ciepluch,
- Academic press:
- International Journal of Biological Macromolecules (year: 2024, volume: 278, pages: 134634), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ijbiomac.2024.134634 – link to the publication
-
Molecular mechanism of action of imidazolium carbosilane dendrimers on the outer bacterial membrane – From membrane damage to permeability to antimicrobial endolysin
- Authors:
- Kinga Skrzyniarz, Samuel Takvor-Mena, Karolina Lach, Małgorzata Łysek-Gładysińska, Óscar Barrios-Gumiel, Jesús Cano, Karol Ciepluch
- Academic press:
- Journal of Colloid And Interface Science (year: 2024, volume: 665, pages: 814-824), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.jcis.2024.03.130 – link to the publication