Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Biocompatible materials with theranostics' properties for precision medical application

2021/43/B/ST5/02960

Keywords:

Biomaterials nanosized phosphate-silicate compounds lithium ions f- and d- elektrons ions tissue regeneration stimulation of cells proliferation and differentiation

Descriptors:

  • ST5_007:
  • ST5_009:
  • ST5_010:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Rafał Jakub Wiglusz 

Number of co-investigators in the project: 10

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 2 553 814 PLN

Project start date (Y-m-d): 2022-06-03

Project end date (Y-m-d): 2026-09-02

Project duration:: 51 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (23)
  1. The Safety of Fluoride Compounds and Their Effect on the Human Body—A Narrative Review
    Authors:
    Adam Lubojanski, Dagmara Piesiak-Panczyszyn, Wojciech Zakrzewski, Wojciech Dobrzynski, Maria Szymonowicz, Zbigniew Rybak, Bartosz Mielan, Rafal J. Wiglusz, Adam Watras, Maciej Dobrzynski
    Academic press:
    Materials (rok: 2023, tom: 16(3), strony: 46042), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma16031242 - link to the publication
  2. Effect of silver ion and silicate group on the antibacterial and antifungal properties of nanosized hydroxyapatite
    Authors:
    Nataliia D. Pinchuk, Agata Piecuch, Natalia Charczuk, Paulina Sobierajska, Sara Targonska, Oleksii Bezkrovnyi, Rafał Ogórek, Yadong Wang & Rafal J. Wiglusz
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 29339), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-024-80303-7 - link to the publication
  3. Nanofluorapatite Hydrogels in the Treatment of Dentin Hypersensitivity: A Study of Physiochemical Properties and Fluoride Release
    Authors:
    Katarzyna Wiglusz, Maciej Dobrzynski, Martina Gutbier, and Rafal J Wiglusz
    Academic press:
    Gels (rok: 2023, tom: 9(4), strony: 46039), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/gels9040271 - link to the publication
  4. Effect of Carbon Fibers Coated With Nanosized Hydroxyapatite on the Strength and Biocompatibility of Polymer Composites
    Authors:
    Sara Targońska, Marta Kardach, Jacek Andrzejewski, Benita Wiatrak, Paulina Nowotarska, Tomasz Gębarowski, Rafal J. Wiglusz
    Academic press:
    Journal of Applied Polymer Science (rok: 2026, tom: 143, strony: e58139), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/app.58139 - link to the publication
  5. Synthesis and Investigation of Physicochemical Properties and Biocompatibility of Phosphate–Vanadate Hydroxyapatite Co-Doped with Tb3+ and Sr2+ Ions
    Authors:
    Natalia Charczuk, Nicole Nowak, and Rafal J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2023, tom: 13(3), strony: 46040), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano13030457 - link to the publication
  6. Multifunctional platform for future applications in cell and tissue engineering based on silicate phosphate hydroxyapatite co-doped with Li+, Eu3+ and Gd3+ ions
    Authors:
    Natalia Charczuk, Sara Targońska, Agnieszka Śmieszek c, Paulina Sobierajska, Piotr Kraszkiewicz, Rafal J. Wiglusz
    Academic press:
    Materials Today Communications (rok: 2024, tom: 39, strony: 108926), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mtcomm.2024.108926 - link to the publication
  7. Investigation of Different Types of Micro- and Nanostructured Materials for Bone Grafting Application
    Authors:
    Sara Targonska, Sebastian Dominiak, Rafal J. Wiglusz, Marzena Dominiak
    Academic press:
    Nanomaterials (rok: 2022, tom: 12(21), strony: 46035), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano12213752 - link to the publication
  8. Comparison of the Fluoride Ion Release from Composite and Compomer Materials under Varying pH Conditions—Preliminary In Vitro Study
    Authors:
    Piotr Kosior, Maciej Dobrzynski, Aneta Zakrzewska, Dorota Diakowska, Jan Nienartowicz, Tomasz Blicharski, Sebastian Nagel, Mateusz Sikora, Katarzyna Wiglusz, Adam Watras, Rafal J. Wiglusz
    Academic press:
    Applied Sciences (rok: 2022, tom: 12(24), strony: 46035), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app122412540 - link to the publication
  9. In Vitro Cytotoxicity Evaluation of Nanosized Hydroxyapatite and Fluorapatite on Cell Lines and Their Relevance to the Alveolar Augmentation Process
    Authors:
    Wojciech Zakrzewski, Maria Szymonowicz, Anna Nikodem, Agnieszka Rusak, Zbigniew Rybak, Katarzyna Szyszka, Dorota Diakowska, Benita Wiatrak, Rafal J. Wiglusz and Maciej Dobrzyński
    Academic press:
    Journal of Functional Biomaterials (rok: 2025, tom: 16, strony: 125), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jfb16040125 - link to the publication
  10. BridgingtheEffectsofNoncontactTemperatureSensingandCellularBiofunctionalityinNanosizedDysprosium(III)-DopedFluorapatite
    Authors:
    Sara Targonska, Natalia Charczuk, Adam Kabanski, Klaudia Marcinkowska, Joanna Sulecka-Zadka, Daria Szymanowska, Agnieszka Śmieszek, Rafal J. Wiglusz
    Academic press:
    Small (rok: 2026, tom: 22, strony: e07537), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/smll.202507537 - link to the publication
  11. The Use of Lactide Polymers in Bone Tissue Regeneration in Dentistry—A Systematic Review
    Authors:
    Justyna Rajewska, Jakub Kowalski, Jacek Matys, Maciej Dobrzyński, and Rafal J. Wiglusz
    Academic press:
    Journal of Functional Biomaterials (rok: 2023, tom: 14(2), strony: 46043), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jfb14020083 - link to the publication
  12. In vitro studies of hemoglobin's affinity for the Vitamin B9 and control of its stability character
    Authors:
    Katarzyna Wiglusz, Ewa Żurawska-Płaksej, Agnieszka Piwowar, Rafal J. Wiglusz
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 271, strony: 132665), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2024.132665 - link to the publication
  13. Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine
    Authors:
    Nicole Nowak, Dominika Czekanowska, John M. Reeks, Rafal J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2022, tom: 12(24), strony: 46042), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano12244475 - link to the publication
  14. Characterization of Sm3+-activated carbonated calcium chlorapatite phosphors for theranostic applications: a comparative study of co-precipitation and hydrothermal methods
    Authors:
    Katarzyna Szyszka and Rafal J. Wiglusz
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2024, tom: 26, strony: 10951-10960), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D3CP06049G - link to the publication
  15. Preparation of nanohydroxyapatite with diverse morphologies and optimization of its effective aqueous colloidal dispersions for biomedical applications
    Authors:
    Nataliia D. Pinchuk, Paulina Sobierajska, Katarzyna Szyszka, Oleksii Bezkrovnyi, Rafal J. Wiglusz
    Academic press:
    Ceramics International (rok: 2024, tom: 50, strony: 27426–27435), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ceramint.2024.05.040 - link to the publication
  16. New silicate-substituted hydroxyapatite materials doped with silver ions as potential antifungal agents
    Authors:
    Agata Piecuch, Sara Targońska, Justyna Rewak-Sorczyńska, Rafał Ogórek, and Rafal J. Wiglusz
    Academic press:
    BMC Microbiology (rok: 2023, tom: 1,09236111111111, strony: 46032), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12866-023-02930-w - link to the publication
  17. Europium(III) and Gadolinium(III) co-doped nanohydroxyapatite with enhanced photoluminescence as potential multimodal bioimaging agent
    Authors:
    Natalia Charczuk, Sara Targońska , Dominika Zákutná, Adam Watras, Adrian Patej, Rafal J. Wiglusz
    Academic press:
    Ceramics International (rok: 2024, tom: 50, strony: 14601–14613), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ceramint.2024.01.372 - link to the publication
  18. The isothermal Boltzmann–Gibbs entropy reduction affects survival of the fruit fly Drosophila melanogaster
    Authors:
    Iwona Gruss, Jacek Twardowski, Małgorzata Samsel-Czekała, Jarosław Beznosiuk, Czesław Wandzel, Kamila Twardowska, and Rafal J. Wiglusz
    Academic press:
    Scientific Reports (rok: 2023, tom: 13:14166, strony: 46030), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-023-41482-x - link to the publication
  19. Metallomic Profile of Placental Tissue and Its Association with Maternal and Neonatal Parameters: A Cross-Sectional ICP-OES Study in Lower Silesia
    Authors:
    Aleksandra Kuzan, Emilia Krolewicz, Marta Kardach, Justyna Rewak-Soroczyńska, Małgorzata Kowalska, Aldona Molęda and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2025, tom: 26, strony: 11985), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms262411985 - link to the publication
  20. Photothermal Conversion Efficiency of Silver and Gold Incorporated Nanosized Apatites for Biomedical Applications
    Authors:
    Nataliia D. Pinchuk, Agnieszka Paściak, Grzegorz Paściak, Paulina Sobierajska, Jacek Chmielowiec, Oleksii Bezkrovnyi, Piotr Kraszkiewicz, and Rafal J. Wiglusz
    Academic press:
    ACS Omega (rok: 2023, tom: 8, strony: 41302–41309), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsomega.3c04809 - link to the publication
  21. Highly cyto- and immune compatible new synthetic fluorapatite nanomaterials co-doped with rubidium(I) and europium(III) ions
    Authors:
    Nicole Nowak, Dominika Czekanowska, Tomasz Gebarowski, Rafal J. Wiglusz
    Academic press:
    Biomaterials Advances (rok: 2024, tom: 156, strony: 213709), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2023.213709 - link to the publication
  22. The Study of Nanosized Silicate-Substituted Hydroxyapatites Co-Doped with Sr2+ and Zn2+ Ions Related to Their Influence on Biological Activities
    Authors:
    Justyna Rewak-Soroczynska, Nicole Nowak, Sara Targonska, Agata Piecuch, Rafal J. Wiglusz
    Academic press:
    Current Issues in Molecular Biology (rok: 2022, tom: 44(12), strony: 6229-6246), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cimb44120425 - link to the publication
  23. Antimicrobial Properties and Cytotoxic Effect Evaluation of Nanosized Hydroxyapatite and Fluorapatite Dedicated for Alveolar Bone Regeneration
    Authors:
    Wojciech Zakrzewski, Zbigniew Rybak, Magdalena Pajączkowska, Joanna Nowicka, Maria Szymonowicz, Agnieszka Rusak, Rafał J. Wiglusz, Katarzyna Szyszka, Jacek Chmielowiec, Grzegorz Chodaczek 6 , Krzysztof Kujawa, Bartosz Mielan and Maciej Dobrzyński
    Academic press:
    Applied Sciences (rok: 2024, tom: 14, strony: 7845), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app14177845 - link to the publication

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