Biocompatible materials with theranostics' properties for precision medical application

2021/43/B/ST5/02960

Keywords

Descriptors

  • ST5_007: Kompozyty, hybrydy organiczno-nieorganiczne itp.
  • ST5_009: Biomateriały, materiały biozgodne
  • ST5_010: Materiały /nanomateriały funkcjonalne, nanocząstki

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego PAN

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Rafał Jakub Wiglusz

Number of co-investigators in the project: 10

Call

OPUS 22 – announced on 2021-09-15

Amount awarded
2 553 814 PLN
Project start date
2022-06-03
Project end date
2026-09-02
Project duration
51 months (the same as in the proposal)
Project status
Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (23)

  1. The Use of Lactide Polymers in Bone Tissue Regeneration in Dentistry—A Systematic Review

    Authors:
    Justyna Rajewska, Jakub Kowalski, Jacek Matys, Maciej Dobrzyński, and Rafal J. Wiglusz
    Academic press:
    Journal of Functional Biomaterials (year: 2023, volume: 14(2), pages: 46043), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jfb14020083 – link to the publication
  2. The Safety of Fluoride Compounds and Their Effect on the Human Body—A Narrative Review

    Authors:
    Adam Lubojanski, Dagmara Piesiak-Panczyszyn, Wojciech Zakrzewski, Wojciech Dobrzynski, Maria Szymonowicz, Zbigniew Rybak, Bartosz Mielan, Rafal J. Wiglusz, Adam Watras, Maciej Dobrzynski
    Academic press:
    Materials (year: 2023, volume: 16(3), pages: 46042), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ma16031242 – link to the publication
  3. Synthesis and Investigation of Physicochemical Properties and Biocompatibility of Phosphate–Vanadate Hydroxyapatite Co-Doped with Tb3+ and Sr2+ Ions

    Authors:
    Natalia Charczuk, Nicole Nowak, and Rafal J. Wiglusz
    Academic press:
    Nanomaterials (year: 2023, volume: 13(3), pages: 46040), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nano13030457 – link to the publication
  4. Preparation of nanohydroxyapatite with diverse morphologies and optimization of its effective aqueous colloidal dispersions for biomedical applications

    Authors:
    Nataliia D. Pinchuk, Paulina Sobierajska, Katarzyna Szyszka, Oleksii Bezkrovnyi, Rafal J. Wiglusz
    Academic press:
    Ceramics International (year: 2024, volume: 50, pages: 27426–27435), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ceramint.2024.05.040 – link to the publication
  5. Effect of silver ion and silicate group on the antibacterial and antifungal properties of nanosized hydroxyapatite

    Authors:
    Nataliia D. Pinchuk, Agata Piecuch, Natalia Charczuk, Paulina Sobierajska, Sara Targonska, Oleksii Bezkrovnyi, Rafał Ogórek, Yadong Wang & Rafal J. Wiglusz
    Academic press:
    Scientific Reports (year: 2024, volume: 14, pages: 29339), Publisher: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-024-80303-7 – link to the publication
  6. In vitro studies of hemoglobin's affinity for the Vitamin B9 and control of its stability character

    Authors:
    Katarzyna Wiglusz, Ewa Żurawska-Płaksej, Agnieszka Piwowar, Rafal J. Wiglusz
    Academic press:
    International Journal of Biological Macromolecules (year: 2024, volume: 271, pages: 132665), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2024.132665 – link to the publication
  7. Multifunctional platform for future applications in cell and tissue engineering based on silicate phosphate hydroxyapatite co-doped with Li+, Eu3+ and Gd3+ ions

    Authors:
    Natalia Charczuk, Sara Targońska, Agnieszka Śmieszek c, Paulina Sobierajska, Piotr Kraszkiewicz, Rafal J. Wiglusz
    Academic press:
    Materials Today Communications (year: 2024, volume: 39, pages: 108926), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mtcomm.2024.108926 – link to the publication
  8. Investigation of Different Types of Micro- and Nanostructured Materials for Bone Grafting Application

    Authors:
    Sara Targonska, Sebastian Dominiak, Rafal J. Wiglusz, Marzena Dominiak
    Academic press:
    Nanomaterials (year: 2022, volume: 12(21), pages: 46035), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nano12213752 – link to the publication
  9. Comparison of the Fluoride Ion Release from Composite and Compomer Materials under Varying pH Conditions—Preliminary In Vitro Study

    Authors:
    Piotr Kosior, Maciej Dobrzynski, Aneta Zakrzewska, Dorota Diakowska, Jan Nienartowicz, Tomasz Blicharski, Sebastian Nagel, Mateusz Sikora, Katarzyna Wiglusz, Adam Watras, Rafal J. Wiglusz
    Academic press:
    Applied Sciences (year: 2022, volume: 12(24), pages: 46035), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/app122412540 – link to the publication
  10. Photothermal Conversion Efficiency of Silver and Gold Incorporated Nanosized Apatites for Biomedical Applications

    Authors:
    Nataliia D. Pinchuk, Agnieszka Paściak, Grzegorz Paściak, Paulina Sobierajska, Jacek Chmielowiec, Oleksii Bezkrovnyi, Piotr Kraszkiewicz, and Rafal J. Wiglusz
    Academic press:
    ACS Omega (year: 2023, volume: 8, pages: 41302–41309), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsomega.3c04809 – link to the publication
  11. New silicate-substituted hydroxyapatite materials doped with silver ions as potential antifungal agents

    Authors:
    Agata Piecuch, Sara Targońska, Justyna Rewak-Sorczyńska, Rafał Ogórek, and Rafal J. Wiglusz
    Academic press:
    BMC Microbiology (year: 2023, volume: 1,09236111111111, pages: 46032), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12866-023-02930-w – link to the publication
  12. Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine

    Authors:
    Nicole Nowak, Dominika Czekanowska, John M. Reeks, Rafal J. Wiglusz
    Academic press:
    Nanomaterials (year: 2022, volume: 12(24), pages: 46042), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nano12244475 – link to the publication
  13. Highly cyto- and immune compatible new synthetic fluorapatite nanomaterials co-doped with rubidium(I) and europium(III) ions

    Authors:
    Nicole Nowak, Dominika Czekanowska, Tomasz Gebarowski, Rafal J. Wiglusz
    Academic press:
    Biomaterials Advances (year: 2024, volume: 156, pages: 213709), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2023.213709 – link to the publication
  14. The Study of Nanosized Silicate-Substituted Hydroxyapatites Co-Doped with Sr2+ and Zn2+ Ions Related to Their Influence on Biological Activities

    Authors:
    Justyna Rewak-Soroczynska, Nicole Nowak, Sara Targonska, Agata Piecuch, Rafal J. Wiglusz
    Academic press:
    Current Issues in Molecular Biology (year: 2022, volume: 44(12), pages: 6229-6246), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cimb44120425 – link to the publication
  15. Europium(III) and Gadolinium(III) co-doped nanohydroxyapatite with enhanced photoluminescence as potential multimodal bioimaging agent

    Authors:
    Natalia Charczuk, Sara Targońska , Dominika Zákutná, Adam Watras, Adrian Patej, Rafal J. Wiglusz
    Academic press:
    Ceramics International (year: 2024, volume: 50, pages: 14601–14613), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ceramint.2024.01.372 – link to the publication
  16. In Vitro Cytotoxicity Evaluation of Nanosized Hydroxyapatite and Fluorapatite on Cell Lines and Their Relevance to the Alveolar Augmentation Process

    Authors:
    Wojciech Zakrzewski, Maria Szymonowicz, Anna Nikodem, Agnieszka Rusak, Zbigniew Rybak, Katarzyna Szyszka, Dorota Diakowska, Benita Wiatrak, Rafal J. Wiglusz and Maciej Dobrzyński
    Academic press:
    Journal of Functional Biomaterials (year: 2025, volume: 16, pages: 125), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jfb16040125 – link to the publication
  17. Nanofluorapatite Hydrogels in the Treatment of Dentin Hypersensitivity: A Study of Physiochemical Properties and Fluoride Release

    Authors:
    Katarzyna Wiglusz, Maciej Dobrzynski, Martina Gutbier, and Rafal J Wiglusz
    Academic press:
    Gels (year: 2023, volume: 9(4), pages: 46039), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/gels9040271 – link to the publication
  18. BridgingtheEffectsofNoncontactTemperatureSensingandCellularBiofunctionalityinNanosizedDysprosium(III)-DopedFluorapatite

    Authors:
    Sara Targonska, Natalia Charczuk, Adam Kabanski, Klaudia Marcinkowska, Joanna Sulecka-Zadka, Daria Szymanowska, Agnieszka Śmieszek, Rafal J. Wiglusz
    Academic press:
    Small (year: 2026, volume: 22, pages: e07537), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/smll.202507537 – link to the publication
  19. The isothermal Boltzmann–Gibbs entropy reduction affects survival of the fruit fly Drosophila melanogaster

    Authors:
    Iwona Gruss, Jacek Twardowski, Małgorzata Samsel-Czekała, Jarosław Beznosiuk, Czesław Wandzel, Kamila Twardowska, and Rafal J. Wiglusz
    Academic press:
    Scientific Reports (year: 2023, volume: 13:14166, pages: 46030), Publisher: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-023-41482-x – link to the publication
  20. Metallomic Profile of Placental Tissue and Its Association with Maternal and Neonatal Parameters: A Cross-Sectional ICP-OES Study in Lower Silesia

    Authors:
    Aleksandra Kuzan, Emilia Krolewicz, Marta Kardach, Justyna Rewak-Soroczyńska, Małgorzata Kowalska, Aldona Molęda and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (year: 2025, volume: 26, pages: 11985), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms262411985 – link to the publication
  21. Effect of Carbon Fibers Coated With Nanosized Hydroxyapatite on the Strength and Biocompatibility of Polymer Composites

    Authors:
    Sara Targońska, Marta Kardach, Jacek Andrzejewski, Benita Wiatrak, Paulina Nowotarska, Tomasz Gębarowski, Rafal J. Wiglusz
    Academic press:
    Journal of Applied Polymer Science (year: 2026, volume: 143, pages: e58139), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/app.58139 – link to the publication
  22. Characterization of Sm3+-activated carbonated calcium chlorapatite phosphors for theranostic applications: a comparative study of co-precipitation and hydrothermal methods

    Authors:
    Katarzyna Szyszka and Rafal J. Wiglusz
    Academic press:
    Physical Chemistry Chemical Physics (year: 2024, volume: 26, pages: 10951-10960), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D3CP06049G – link to the publication
  23. Antimicrobial Properties and Cytotoxic Effect Evaluation of Nanosized Hydroxyapatite and Fluorapatite Dedicated for Alveolar Bone Regeneration

    Authors:
    Wojciech Zakrzewski, Zbigniew Rybak, Magdalena Pajączkowska, Joanna Nowicka, Maria Szymonowicz, Agnieszka Rusak, Rafał J. Wiglusz, Katarzyna Szyszka, Jacek Chmielowiec, Grzegorz Chodaczek 6 , Krzysztof Kujawa, Bartosz Mielan and Maciej Dobrzyński
    Academic press:
    Applied Sciences (year: 2024, volume: 14, pages: 7845), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/app14177845 – link to the publication

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Graphic design and implementation: Jakub Piotrowski