Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Deciphering the molecular mechanism of activity switch of the ubiquitin ligase CHIP

2021/41/N/NZ1/03086

Keywords:

protein complexes E3 ubiquitin ligases CHIP UFD-2 heat shock protein 70 (HSP70) protein crystallization cryo-EM

Descriptors:

  • NZ1_004:
  • NZ1_001:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Pankaj Thapa 

Number of co-investigators in the project: 2

Call: PRELUDIUM 20 - announced on 2021-03-15

Amount awarded: 132 126 PLN

Project start date (Y-m-d): 2022-02-01

Project end date (Y-m-d): 2025-01-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. HSP70 inhibits CHIP E3 ligase activity to maintain germline function in Caenorhabditis elegans
    Authors:
    Pankaj Thapa, Rupesh V. Chikale, Natalia A. Szulc, Maria-Teodora Pandrea, Agnieszka Sztyler, Khushboo Jaggi, Marta Niklewicz, Remigiusz A. Serwa, Thorsten Hoppe, Wojciech Pokrzywa
    Academic press:
    Journal of Biological Chemistry (rok: 2024, tom: Volume 300, strony: 8), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1016/j.jbc.2024.107864 - link to the publication
  2. SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model
    Authors:
    Pankaj Thapa, Katarzyna Olek, Agata Kowalska, Remigiusz A. Serwa & Wojciech Pokrzywa
    Academic press:
    npj aging (rok: 2023, tom: 9, strony: 27), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41514-023-00125-1 - link to the publication
  3. SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model
    Authors:
    Pankaj Thapa, Katarzyna Olek, Agata Kowalska, Remigiusz A. Serwa & Wojciech Pokrzywa
    Academic press:
    npj aging (rok: 2023, tom: 9, strony: 27), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41514-023-00125-1 - link to the publication

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