Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Close Encounters of the Third Kind: what happens when ribonuclease Dicer encounters in the cell RNA and DNA adopting G-quadruplex structures

2021/41/B/NZ2/03781

Keywords:

nucleic acid binding proteins RNA-protein interactions DNA-protein interactions Dicer ribonuclease G-quadruplexes regulatory RNAs regulation of gene expression

Descriptors:

  • NZ2_002:
  • NZ1_001:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Maria Kurzyńska-Kokorniak 

Number of co-investigators in the project: 6

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 2 158 840 PLN

Project start date (Y-m-d): 2022-03-01

Project end date (Y-m-d): 2027-02-28

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Short 2'-O-methyl/LNA oligomers as highly-selective inhibitors of miRNA production in vitro and in vivo
    Authors:
    Natalia Koralewska, Eloina Corradi, Marek C. Milewski, Linda Masante, Agnieszka Szczepanska, Ryszard Kierzek, Marek Figlerowicz, Marie-Laure Baudet, Anna Kurzynska-Kokorniak
    Academic press:
    Nucleic Acids Research (rok: 2024, tom: 52(10), strony: 5804–5824), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gkae284 - link to the publication
  2. Structural studies of protein-nucleic acid complexes: A brief overview of the selected techniques
    Authors:
    Kamil Szpotkowski, Klaudia Wójcik, Anna Kurzyńska-Kokorniak
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2023, tom: 21, strony: 2858–2872), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.csbj.2023.04.028 - link to the publication
  3. The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding
    Authors:
    Kinga Ciechanowska, Agnieszka Szczepanska, Kamil Szpotkowski, Klaudia Wojcik, Anna Urbanowicz, Anna Kurzynska-Kokorniak
    Academic press:
    BMC Biology (rok: 2024, tom: 22(1), strony: 287), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12915-024-02082-x - link to the publication

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