Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Genetic and epigenetic fundamentals of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

2021/41/N/NZ2/00844

Keywords:

Single-nucleotide polymorphism Epigenetics DNA methylation Subarachnoid hemorrhage Aneurysm

Descriptors:

  • NZ2_002:
  • NZ5_003:
  • NZ4_010:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Tomasz Klepinowski 

Number of co-investigators in the project: 3

Call: PRELUDIUM 20 - announced on 2021-03-15

Amount awarded: 209 998 PLN

Project start date (Y-m-d): 2022-01-13

Project end date (Y-m-d): 2025-01-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Epigenome-wide DNA methylation profiling in aneurysmal subarachnoid hemorrhage and delayed ischemic neurologic deficit: a prospective observational study
    Authors:
    Tomasz Klepinowski, Patrycja Przybyłowicz, Olga Taryma-Leśniak, Jan Bińkowski, Dagmara Lisman, Andrzej Ossowski, Konrad Jarosz, Marcin Sawicki, Wojciech Poncyljusz, Dominik Taterra, Kajetan Łątka, Tomasz K. Wojdacz, Leszek Sagan
    Academic press:
    International Journal of Surgery (rok: 2025, tom: 112(1), strony: 832-843), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/js9.0000000000003324 - link to the publication
  2. A prospective pilot study of gut microbiome in cerebral vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
    Authors:
    Tomasz Klepinowski, Karolina Skonieczna-Żydecka, Igor Łoniewski, Samuel D. Pettersson, Anna Wierzbicka-Woś, Mariusz Kaczmarczyk, Joanna Palma, Marcin Sawicki, Dominik Taterra, Wojciech Poncyljusz, Nabeel S. Alshafai, Ewa Stachowska, Christopher S. Ogilvy, Leszek Sagan
    Academic press:
    Scientific Reports (rok: 2024, tom: 14:17617, strony: 46034), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-68722-y - link to the publication
  3. Differential DNA methylation associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review
    Authors:
    Tomasz Klepinowski, Bartłomiej Pala, Samuel D. Pettersson, Kajetan Łątka, Dominik Taterra, Christopher S. Ogilvy, Leszek Sagan
    Academic press:
    Neurosurgical Review (rok: 2024, tom: 47 (144), strony: 46038), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10143-024-02381-5 - link to the publication
  4. Gut microbiome in intracranial aneurysm growth, subarachnoid hemorrhage, and cerebral vasospasm: a systematic review with a narrative synthesis
    Authors:
    Tomasz Klepinowski, Karolina Skonieczna-Żydecka, Bartłomiej Pala, Ewa Stachowska, Leszek Sagan
    Academic press:
    Frontiers in Neuroscience (rok: 2023, tom: 17, strony: 46034), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnins.2023.1247151 - link to the publication

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