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Molecular analysis of thermomstability of endolysins from extremophilic bacteriophages on a way to combat Gram-negative bacteria

2020/39/B/NZ6/00589

Keywords:

thermostability endolysins antibacterial agents Gram-negative bacteria

Descriptors:

  • NZ6_004:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Agata Płotka 

Number of co-investigators in the project: 3

Call: OPUS 20 - announced on 2020-09-15

Amount awarded: 1 485 600 PLN

Project start date (Y-m-d): 2021-07-12

Project end date (Y-m-d): 2026-07-11

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. A novel cryptic clostridial peptide that kills bacteria by cell membrane permeabilization mechanism
    Authors:
    Monika Szadkowska, Michal Olewniczak, Anna Kloska, Elzbieta Jankowska, Malgorzata Kapusta, Bartosz Rybak, Dariusz Wyrzykowski, Wioletta Zmudzinska, Artur Gieldon, Aleksandra Kocot, Anna-Karina Kaczorowska, Lukasz Nierzwicki, Joanna Makowska, Tadeusz Kaczorowski, Magdalena Plotka
    Academic press:
    Microbiology spectrum (rok: 2022, tom: 10, strony: 45676), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/spectrum.01657-22 - link to the publication
  2. Molecular characterization of the PhiKo endolysin from Thermus thermophilus HB27 bacteriophage phiKo and its cryptic lytic peptide RAP-29
    Authors:
    Szadkowska Monika, Kocot Aleksandra Maria, Sowik Daria, Wyrzykowski Dariusz, Jankowska Elzbieta, Kozlowski Lukasz Pawel, Makowska Joanna, Plotka Magdalena
    Academic press:
    Frontiers in Microbiology (rok: 2024, tom: 14, strony: 45673), Wydawca: FRONTIERS MEDIA SA
    Status:
    Published
    DOI:
    10.3389/fmicb.2023.1303794 - link to the publication
  3. Comparison of the Antibacterial Activity of Selected Deep Eutectic Solvents (DESs) and Deep Eutectic Solvents Comprising Organic Acids (OA-DESs) Towards Gram-positive and Gram-negative Species
    Authors:
    Tomasz Swebocki, Aleksandra M. Kocot, Alexandre Barras, Helena Arellano, Leila Bonnaud, Kamel Haddadi, Anne-Laure Fameau, Sabine Szunerits, Magdalena Plotka, Rabah Boukherroub
    Academic press:
    Advanced Healthcare Materials (rok: 2024, tom: 4:e2303475, strony: 11689), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/adhm.202303475 - link to the publication
  4. Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii
    Authors:
    Aleksandra Maria Kocot, Tomasz Swebocki, Karolina Ciemińska, Adrianna Łupkowska, Małgorzata Kapusta, Dennis Grimon, Ewa Laskowska, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Rabah Boukherroub, Yves Briers, Magdalena Plotka
    Academic press:
    Scientific Reports (rok: 2025, tom: 2,04652777777778, strony: 45675), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-80440-z - link to the publication
  5. Phages and engineered lysins as an effective tool to combat Gram-negative foodborne pathogens
    Authors:
    Aleksandra Maria Kocot, Yves Briers, Magdalena Plotka
    Academic press:
    Comprehensive Reviews in Food Science and Food Safety (rok: 2023, tom: 22, strony: 2235–2266), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/1541-4337.13145 - link to the publication

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