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The influence of menaquinone-7 on leukocyte and CD4+ transcriptomes in ulcerative colitis: a randomized controlled trial

2020/39/D/NZ5/02720

Keywords:

inflammatory bowel disease transcriptome expression

Descriptors:

  • NZ5_007:
  • NZ2_002:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Jan Krzysztof Nowak 

Number of co-investigators in the project: 7

Call: SONATA 16 - announced on 2020-09-15

Amount awarded: 758 208 PLN

Project start date (Y-m-d): 2021-06-11

Project end date (Y-m-d): 2025-06-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Study designs in medical research and their key characteristics
    Authors:
    Jan K. Nowak, Jarosław Walkowiak
    Academic press:
    Journal of Medical Science (rok: 2024, tom: 92, strony: 305-315), Wydawca: Uniwersytet Medyczny w Poznaniu
    Status:
    Published
    DOI:
    10.20883/medical.e928 - link to the publication
  2. Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease
    Authors:
    Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo-Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu, Jack Satsangi, Evropi Theodoratou, Xue Li
    Academic press:
    Nature Communications (rok: 2024, tom: 15, strony: 595), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-024-44841-y - link to the publication
  3. Stability of Blood DNA Methylation Across Two Timepoints in Three Cohorts
    Authors:
    Mikołaj Danielewski, Jarosław Walkowiak, Karolina Wielgus, Jan Krzysztof Nowak
    Academic press:
    Biomedicines (rok: 2024, tom: 12(11), strony: 2557), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines12112557 - link to the publication
  4. Defining Interactions Between the Genome, Epigenome, and the Environment in Inflammatory Bowel Disease: Progress and Prospects
    Authors:
    Alexandra J. Noble, Jan K. Nowak, Alex T. Adams, Holm H. Uhlig, Jack Satsangi
    Academic press:
    Gastroenterology (rok: 2023, tom: 165, strony: 44-60.e2), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1053/j.gastro.2023.03.238 - link to the publication
  5. Current and emerging biomarkers for ulcerative colitis
    Authors:
    Nowak JK, Kalla R, Satsangi J
    Academic press:
    Expert Review of Molecular Diagnostics (rok: 2023, tom: 23, strony: 1107-1119), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14737159.2023.2279611 - link to the publication
  6. Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region
    Authors:
    Jie Chen, Han Zhang, Tian Fu, Jianhui Zhao, Jan Krzysztof Nowak, Rahul Kalla, Judith Wellens, Shuai Yuan, Alexandra Noble, Nicholas T. Ventham, Malcolm G. Dunlop, Jonas Halfvarson, Ren Mao, Evropi Theodoratou, Jack Satsangi, Xue Li
    Academic press:
    eBioMedicine (rok: 2024, tom: 110, strony: 46040), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.ebiom.2024.105443 - link to the publication

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