Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel mechanism of gene expression control in Eukaryota through regulation of protein-coding transcript polyadenosine tail length

2020/39/D/NZ2/02174

Keywords:

gene expression regulation deadenylation CCR4-NOT PAN2/3 polyA binding proteins

Descriptors:

  • NZ2_002:
  • NZ2_007:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Irena Tudek 

Number of co-investigators in the project: 4

Call: SONATA 16 - announced on 2020-09-15

Amount awarded: 1 642 400 PLN

Project start date (Y-m-d): 2021-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Book publications / chapters in book publications (2)
  1. Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay
    Authors:
    Agnieszka Czarnocka-Cieciura, Jarosław Poznański, Matti Turtola, Rafał Tomecki, Paweł S Krawczyk, Seweryn Mroczek, Wiktoria Orzeł, Upasana Saha, Torben Heick Jensen, Andrzej Dziembowski, Agnieszka Tudek
    Academic press:
    EMBO Journal (rok: 2024, tom: 43, strony: 6525-6554), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s44318-024-00258-3 - link to the publication
  2. A cap 0-dependent mRNA capture method to analyze the yeast transcriptome.
    Authors:
    Nowacka M, Latoch P, Izert MA, Karolak NK, Tomecki R, Koper M, Tudek A, Starosta AL, Górna MW.
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 2,09861111111111, strony: e132), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkac903 - link to the publication
  1. Transcriptome-Wide Analysis of mRNA Adenylation Status in Yeast Using Nanopore Sequencing
    Authors:
    Paweł Krawczyk, Agnieszka Tudek, Seweryn Mroczek, Andrzej Dziembowski
    Book:
    Methods in Molecular Biology (rok: 2023, tom: 2723, strony: 193-214), Wydawca: Springer (Humana Press)
    Status:
    Published
    DOI:
    10.1007/978-1-0716-3481-3_12 - link to the publication
  2. Purification of Enzymatically Active Xrn1 for Removal of Non-capped mRNAs from In Vitro Transcription Reactions and Evaluation of mRNA Decapping Status In Vivo
    Authors:
    Karolina Drążkowska, Rafał Tomecki, Agnieszka Tudek
    Book:
    mRNA Decay (rok: 2024, tom: 2863, strony: 81-105), Wydawca: Springer Nature
    Status:
    Published

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