The role of the Fas/FasL pathway in neurodegeneration caused by herpes simplex type 1 (HSV-1) infection

2020/37/B/NZ6/03284

Keywords

Descriptors

  • NZ6_005: Wirusologia

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Małgorzata Krzyżowska

Number of co-investigators in the project: 4

Call

OPUS 19 – announced on 2020-03-16

Amount awarded
831 600 PLN
Project start date
2021-02-15
Project end date
2024-02-14
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (4)

  1. Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration.

    Authors:
    Patrycy M, Chodkowski M, Krzyzowska M.
    Academic press:
    Pathogens (year: 2022, volume: 11, pages: 809), Publisher: mdpi
    Status:
    Published
    DOI:
    10.3390/pathogens11070809 – link to the publication
  2. The Role of Nitric Oxide in HSV-1 Infection: The Use of an Inducible Nitric Synthase Inhibitor Aminoguanidine to Treat Neuroinflammation

    Authors:
    Patrycy, M.; Janicka, M.; Kauc, A.; Osińska, A.; Antos-Bielska, M.; Bylińska, K.; Obuch-Woszczatyńska, O.; Szymański, P.; Chodkowski, M.; Krzyżowska, M.
    Academic press:
    Microorganisms (year: 2025, volume: 13, pages: 2222), Publisher: mdpi
    Status:
    Published
    DOI:
    10.3390/microorganisms13102222 – link to the publication
  3. Fas/FasL-Mediated Apoptosis and Inflammation Contribute to Recovery from HSV-2-Mediated Spinal Cord Infection.

    Authors:
    Krzyzowska M, Patrycy M, Chodkowski M, Janicka M, Kowalczyk A, Skulska K, Thörn K, Eriksson K.
    Academic press:
    Viruses (year: 2024, volume: 16(9), pages: 1363), Publisher: mdpi
    Status:
    Published
    DOI:
    10.3390/v16091363 – link to the publication
  4. Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation

    Authors:
    Krzyzowska M, Kowalczyk A, Skulska K, Thörn K, Eriksson K
    Academic press:
    Frontiers in Immunology (year: 2021, volume: 12, pages: 46038), Publisher: Frontiers
    Status:
    Published
    DOI:
    link to the publication

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