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Information on the principal investigator and host institution

Information of the project and the call

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To what extent the transcriptomic response in the events initiating lung toxicity in mice depends on the structural features of the nanoparticles that cause it - TransNANO?

2020/37/B/ST5/01894

Keywords:

structure-properties and structure-toxicity relations of nanomaterials predictive models for transcriptomic toxicity based on the (macro)molecular architecture advices for developing nanomaterials safe-by-design

Descriptors:

  • ST5_013:
  • ST5_001:
  • NZ7_015:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Puzyn 

Number of co-investigators in the project: 4

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 749 520 PLN

Project start date (Y-m-d): 2021-10-01

Project end date (Y-m-d): 2026-09-30

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. TRIumph in nanotoxicology: simplifying transcriptomics into a single predictive variable
    Authors:
    Viacheslav Muratov , Karolina Jagiełło, Tomasz Puzyn
    Academic press:
    Nanoscale Horizons (rok: 2025, tom: 10, strony: 3116-3126), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D5NH00330J - link to the publication
  2. A bibliometric analysis of the recent achievements in pulmonary safety of nanoparticles
    Authors:
    K. Falkiewicz, I. Fryca, K. Ciura, A. Mikolajczyk, K. Jagiello, T. Puzyn
    Academic press:
    Nanotoxicology (rok: 2023, tom: 17, strony: 547-561), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17435390.2023.2276411 - link to the publication
  3. The impact of carbon nanotube properties on lung pathologies and atherosclerosis through acute inflammation: a new AOP-anchored in silico NAM
    Authors:
    Sattibabu Merugu , Karolina Jagiełło, Agnieszka Gajewicz-Skrętna, Sabina Halappanavar, Andrew Williams, Ulla Vogel, Tomasz Puzyn
    Academic press:
    Small (rok: 2025, tom: 21, strony: 2501185 (1 of 10)), Wydawca: Wiley-VCH GmbH, Weinheim
    Status:
    Published
    DOI:
    10.1002/smll.202501185 - link to the publication
  4. The role of machine learning in predicting titanium dioxide nanoparticles induced pulmonary pathology using transcriptomic biomarkers
    Authors:
    Viacheslav Muratov, Karolina Jagiełło, Alicja Mikołajczyk, Pernille Hogh Danielsen, Sabina Halappanavar, Ulla Vogel, Tomasz Puzyn
    Academic press:
    Journal of Hazardous Materials (rok: 2025, tom: 493, strony: 138240), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jhazmat.2025.138240 - link to the publication
  5. Toward nano-specific in silico NAMs: How to adjust nano-QSAR to the recent advancements of nanotoxicology?
    Authors:
    K. Ciura, E. Moschini, M. Stępnik. T. Serchi, A. Gutleb, K. Jarzyńska, K. Jagiello, T. Puzyn
    Academic press:
    Small (rok: 2024, tom: 20, strony: 2305581), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/smll.202305581 - link to the publication
  6. An ancestral molecular response to nanomaterial particulates
    Authors:
    G. del Giudice, A. Serra, L. A. Saarimäki, K. Kotsis, I. Rouse, S. A. Colibaba, K. Jagiello, A. Mikolajczyk, M. Fratello, A. G. Papadiamantis, N. Sanabria, M. E. Annala, J. Morikka, P. A. S. Kinaret, E. Voyiatzis, G. Melagraki, A. Afantitis, K. Tämm, T. Puzyn, M. Gulumian, V. Lobaskin, I. Lynch, A. Federico & D. Greco
    Academic press:
    Nature Nanotechnology (rok: 2023, tom: 18, strony: 957–966), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41565-023-01393-4 - link to the publication

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