Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Co-amorphous polyphenol systems

2020/37/B/NZ7/03975

Keywords:

polyphenols amorphous dispertion solubility permeability biological activity

Descriptors:

  • NZ7_012:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Judyta Agnieszka Cielecka-Piontek 

Number of co-investigators in the project: 5

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 2 311 200 PLN

Project start date (Y-m-d): 2021-02-05

Project end date (Y-m-d): 2026-02-04

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (27)
  1. Sweeteners Show a Plasticizing Effect on PVP K30—A Solution for the Hot-Melt Extrusion of Fixed-Dose Amorphous Curcumin-Hesperetin Solid Dispersions.
    Authors:
    Wdowiak Kamil, Tajber Lidia, Miklaszewski Andrzej, Cielecka-Piontek Judyta
    Academic press:
    Pharmaceutics (rok: 2024, tom: 16,5, strony: 659), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics16050659 - link to the publication
  2. Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential.
    Authors:
    Natalia Rosiak, Ewa Tykarska, and Judyta Cielecka-Piontek
    Academic press:
    Molecules (rok: 2024, tom: 29,6, strony: 1287), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules29061287 - link to the publication
  3. Haskap Berry Leaves (Lonicera caerulea L.)—The Favorable Potential of Medical Use
    Authors:
    Szymon Sip, Anna Sip, Piotr Szulc, Judyta Cielecka-Piontek
    Academic press:
    Nutrients (rok: 2022, tom: 14(19), strony: 3898), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu14193898 - link to the publication
  4. Amorphous pterostilbene delivery systems preparation – in-novative approach to preparation optimization
    Authors:
    Natalia Rosiak, Ewa Tykarska, Judyta Cielecka-Piontek
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15(4), strony: 1231), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15041231 - link to the publication
  5. Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity.
    Authors:
    Rosiak, Natalia, Ewa Tykarska, and Judyta Cielecka-Piontek
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25,7, strony: 3648), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25073648 - link to the publication
  6. The Study of Amorphous Kaempferol Dispersions Involving FT-IR Spectroscopy
    Authors:
    Rosiak, N.; Tykarska, E.; Cielecka-Piontek, J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 17155), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms242417155 - link to the publication
  7. Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats
    Authors:
    Sip S, Szymanowska D, Chanaj-Kaczmarek J, Skalicka-Woźniak K, Budzyńska B, Wronikowska-Denysiuk O, Słowik T, Szulc P, Cielecka-Piontek J.
    Academic press:
    Antioxidants (rok: 2022, tom: 11(2), strony: 380), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox11020380 - link to the publication
  8. Cyclodextrin Derivatives as Promising Solubilizers to Enhance the Biological Activity of Rosmarinic Acid
    Authors:
    Anna Stasiłowicz-Krzemień, Natalia Rosiak, Anita Płazińska, Wojciech Płaziński, Andrzej Miklaszewski, Ewa Tykarska, Judyta Cielecka-Piontek 1
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14(10), strony: 2098), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14102098 - link to the publication
  9. Bioavailability of Hesperidin and Its Aglycone Hesperetin—Compounds Found in Citrus Fruits as a Parameter Conditioning the Pro-Health Potential (Neuroprotective and Antidiabetic Activity)—Mini-Review
    Authors:
    Kamil Wdowiak, Jarosław Walkowiak, Robert Pietrzak, Aleksandra Bazan-Woźniak, Judyta Cielecka-Piontek
    Academic press:
    Nutrients (rok: 2022, tom: 14(13), strony: 2647), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu14132647 - link to the publication
  10. Zein as an effective carrier for hesperidin delivery systems with improved prebiotic potential
    Authors:
    Sip, S.; Sip, A.; Miklaszewski, A.; Żarowski, M.; Cielecka-Piontek, J.
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 5209), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28135209 - link to the publication
  11. Potential for Prebiotic Stabilized Cornus mas L. Lyophilized Extract in the Prophylaxis of Diabetes Mellitus in Streptozotocin Diabetic Rats
    Authors:
    Sip S, Szymanowska D, Chanaj-Kaczmarek J, Skalicka-Woźniak K, Budzyńska B, Wronikowska-Denysiuk O, Słowik T, Szulc P, Cielecka-Piontek J.
    Academic press:
    Antioxidants (rok: 2022, tom: 11(2), strony: 380), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox11020380 - link to the publication
  12. Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities
    Authors:
    Wdowiak, K.; Pietrzak, R.; Tykarska, E.; Cielecka-Piontek, J.
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 3848), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28093848 - link to the publication
  13. Permeability of Hypogymnia physodes Extract Component—Physodic Acid through the Blood–Brain Barrier as an Important Argument for Its Anticancer and Neuroprotective Activity within the Central Nervous System
    Authors:
    Studzińska-Sroka, E.; Majchrzak-Celińska, A.; Zalewski, P.; Szwajgier, D.; Baranowska-Wójcik, E.; Żarowski, M.; Plech, T.; Cielecka-Piontek, J.
    Academic press:
    Cancers (rok: 2021, tom: 13,7, strony: 1717), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13071717 - link to the publication
  14. A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide
    Authors:
    Sip, S.; Rosiak, N.; Sip, A.; Żarowski, M.; Hojan, K.; Cielecka-Piontek, J.
    Academic press:
    Antioxidants (rok: 2023, tom: 13, strony: 24), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox13010024 - link to the publication
  15. Enhanced Antioxidant and Neuroprotective Properties of Pterostilbene (Resveratrol Derivative) in Amorphous Solid Dispersions.
    Authors:
    Natalia Rosiak, Ewa Tykarska, and Judyta Cielecka-Piontek
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25,5, strony: 2774), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25052774 - link to the publication
  16. Amorphous Polymer–Phospholipid Solid Dispersions for the Co-Delivery of Curcumin and Piperine Prepared via Hot-Melt Extrusion.
    Authors:
    Wdowiak, Kamil, Andrzej Miklaszewski, Judyta Cielecka-Piontek
    Academic press:
    Pharmaceutics (rok: 2024, tom: 16,8, strony: 999), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics16080999 - link to the publication
  17. Amorphous inclusion complexes: molecular interactions of hesperidin and hesperetin with HP-β-CD and their biological effects
    Authors:
    Wdowiak K., Rosiak N.,Tykarska E. , Żarowski M., Płazińska A., Płaziński W., Cielecka-Piontek J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(7), strony: 4000), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23074000 - link to the publication
  18. Genistein—Opportunities Related to an Interesting Molecule of Natural Origin
    Authors:
    Garbiec E, Cielecka-Piontek J, Kowalówka M, Hołubiec M, Zalewski P. Genistein—Opportunities Related to an Interesting Molecule of Natural Origin
    Academic press:
    Molecules (rok: 2022, tom: 27(3), strony: 815), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27030815 - link to the publication
  19. Amorphous System of Hesperetin and Piperine—Improvement of Apparent Solubility, Permeability, and Biological Activities
    Authors:
    Kamil Wdowiak, Andrzej Miklaszewski, Robert Pietrzak, Judyta Cielecka-Piontek
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(5), strony: 4859), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24054859 - link to the publication
  20. The Study of Amorphous Kaempferol Dispersions Involving FT-IR Spectroscopy
    Authors:
    Rosiak, N.; Tykarska, E.; Cielecka-Piontek, J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 17155), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms242417155 - link to the publication
  21. Zein as an effective carrier for hesperidin delivery systems with improved prebiotic potential
    Authors:
    Sip, S.; Sip, A.; Miklaszewski, A.; Żarowski, M.; Cielecka-Piontek, J.
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 5209), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28135209 - link to the publication
  22. Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review
    Authors:
    Szymczak, J.; Cielecka-Piontek, J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 14158), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241814158 - link to the publication
  23. A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide
    Authors:
    Sip, S.; Rosiak, N.; Sip, A.; Żarowski, M.; Hojan, K.; Cielecka-Piontek, J.
    Academic press:
    Antioxidants (rok: 2023, tom: 13, strony: 24), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox13010024 - link to the publication
  24. Genistein Co-Amorphous Systems with Amino Acids: An Investigation into Enhanced Solubility and Biological Activity
    Authors:
    Garbiec, E.; Rosiak, N.; Zalewski, P.; Tajber, L.; Cielecka-Piontek, J.
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15, strony: 2653), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15122653 - link to the publication
  25. Sinapic Acid Co-Amorphous Systems with Amino Acids for Improved Solubility and Antioxidant Activity
    Authors:
    Ewa Garbiec, Natalia Rosiak, Ewa Tykarska, Przemysław Zalewski, Judyta Cielecka-Piontek
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(6), strony: 5533), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24065533 - link to the publication
  26. Screening of the Anti-Neurodegenerative Activity of Caffeic Acid after Introduction into Inorganic Metal Delivery Systems to Increase Its Solubility as the Result of a Mechanosynthetic Approach
    Authors:
    Stasiłowicz-Krzemień, A.; Rosiak, N.; Miklaszewski, A.; Cielecka-Piontek, J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 9218), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24119218 - link to the publication
  27. Amorphous Solid Dispersion of Hesperidin with Polymer Excipients for Enhanced Apparent Solubility as a More Effective Approach to the Treatment of Civilization Diseases
    Authors:
    Natalia Rosiak, Kamil Wdowiak, Ewa Tykarska, Judyta Cielecka-Piontek 1
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 15198), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232315198 - link to the publication

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