Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Epigenetic immunomodulation dependent on elements of the microbiome. Model of direct and indirect interactions of Th17 and Treg cells with Staphylococcus aureus in the course of psoriasis.

2020/37/B/NZ5/01029

Keywords:

Th17 Treg Staphylococcus aureus psoriasis epigenetics immunomodulation.

Descriptors:

  • NZ5_001:
  • NZ5_003:
  • NZ5_007:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Biologii Medycznej Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Marek Ratajewski 

Number of co-investigators in the project: 5

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 1 585 200 PLN

Project start date (Y-m-d): 2021-01-26

Project end date (Y-m-d): 2026-01-25

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. α-Hemolysin from Staphylococcus aureus Changes the Epigenetic Landscape of Th17 Cells
    Authors:
    Pastwińska J, Karwaciak I, Karaś K, Sałkowska A, Chałaśkiewicz K, Strapagiel D, Sobalska-Kwapis M, Dastych J, Ratajewski M.
    Academic press:
    ImmunoHorizons (rok: 2024, tom: 8 (9), strony: 606-621), Wydawca: The American Association of Immunologists, Inc.
    Status:
    Published
    DOI:
    10.4049/immunohorizons.2400061 - link to the publication
  2. Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes
    Authors:
    Iwona Karwaciak, Kaja Karaś, Anna Sałkowska, Joanna Pastwińska, Marcin Ratajewski
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 3651), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27123651 - link to the publication
  3. α-Hemolysin from Staphylococcus aureus Changes the Epigenetic Landscape of Th17 Cells
    Authors:
    Pastwińska J, Karwaciak I, Karaś K, Sałkowska A, Chałaśkiewicz K, Strapagiel D, Sobalska-Kwapis M, Dastych J, Ratajewski M.
    Academic press:
    ImmunoHorizons (rok: 2024, tom: 8 (9), strony: 606-621), Wydawca: The American Association of Immunologists, Inc.
    Status:
    Published
    DOI:
    10.4049/immunohorizons.2400061 - link to the publication

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