(TNT-CVD), Trimethylamine as a Nitrogenous Toxin in Cardiovascular Diseases.
2020/37/B/NZ5/00366
Keywords
Descriptors
- NZ5_001: Etiologia chorób człowieka
- NZ5_003: Patogeneza chorób człowieka
- NZ4_004: Patofizjologia ogólna
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Warszawski Uniwersytet Medyczny
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 19 – announced on 2020-03-16
- Amount awarded
- 1 998 000 PLN
- Project start date
- 2021-01-19
- Project end date
- 2025-07-18
- Project duration
- 54 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (10)
-
Enalapril Diminishes the Diabetes‐Induced Changes in Intestinal Morphology, Intestinal RAS and Blood SCFA Concentration in Rats
- Authors:
- Kinga Jaworska, Wojciech Kopacz, Mateusz Koper, Mateusz Szudzik, Marta Gawryś‐Kopczyńska, Marek Konop, Tomasz Hutsch, Dawid Chabowski and Marcin Ufnal
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 46034), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms23116060 – link to the publication
-
Symmetric Dimethylarginine is Altered in Patients After Myocardial Infarction and Predicts Adverse Outcomes
- Authors:
- Aleksandra Gąsecka 1 , Piotr Szwed 1 , Karolina Jasińska 1 , Oliwia Fidali 1 , Aleksandra Kłębukowska 1 , Ceren Eyileten 2 , Marek Postula 2 , Łukasz Szarpak 3 4 , Tomasz Mazurek 1 , Grzegorz Opolski 1 , Krzysztof J Filipiak 1 , Marcin Ufnal 5
- Academic press:
- Journal of Inflammation Research (year: 2022, volume: 10, pages: 14:3797-3808), Publisher: DOVE
- Status:
- Published
- DOI:
- 10.2147/JIR.S316078 – link to the publication
-
Spontaneously hypertensive rats exhibit increased liver flavin monooxygenase expression and elevated plasma TMAO levels compared to normotensive and Ang II-dependent hypertensive rats
- Authors:
- Marta Gawryś-Kopczyńska, Mateusz Szudzik, Emilia Samborowska, Marek Konop, Dawid Chabowski, Maksymilian Onyszkiewicz, Marcin Ufnal
- Academic press:
- Frontiers in Physiology (year: 2024, volume: 15:1340166., pages: 46031), Publisher: Frontiers
- Status:
- Published
- DOI:
- 10.3389/fphys.2024.1340166 – link to the publication
-
Normal caloric intake with high-fat diet induces metabolic dysfunction-associated steatotic liver disease and dyslipidemia without obesity in rats
- Authors:
- Mateusz Szudzik, Tomasz Hutsch, Dawid Chabowski, Mikołaj Zajdel, Marcin Ufnal
- Academic press:
- Scientific Reports (year: 2024, volume: 14:22796, pages: 46032), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1038/s41598-024-74193-y – link to the publication
-
Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities
- Authors:
- Kinga Jaworska, Wojciech Kopacz, Mateusz Koper, Marcin Ufnal
- Academic press:
- International Journal of Molecular Sciences (year: 2024, volume: 25, pages: 46039), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms252312511 – link to the publication
-
Deoxycholic Acid, a Secondary Bile Acid, Increases Cardiac Output and Blood Pressure in Rats
- Authors:
- Artur Nowiński, Dawid Chabowski , Joanna Giebułtowicz, Marta Aleksandrowicz, Marcin Ufnal
- Academic press:
- Nutrients (year: 2023, volume: 21, pages: 46032), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/nu16010032 – link to the publication
-
Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction
- Authors:
- Aleksandra Gąsecka, Oliwia Fidali, Aleksandra Kłębukowska, Karolina Jasińska-Gniadzik, Piotr Szwed, Karolina Witkowska, Ceren Eyileten, Marek Postuła, Marcin Grabowski, Krzysztof J. Filipiak, Marcin Ufnal
- Academic press:
- Advances in Interventional Cardiology (year: 2022, volume: 18, pages: 46031), Publisher: Termedia Publishing House
- Status:
- Published
- DOI:
- 10.5114/aic.2022.123884 – link to the publication
-
Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases
- Authors:
- Klaudia M Maksymiuk , Mateusz Szudzik , Emilia Samborowska, Dawid Chabowski, Marek Konop, Marcin Ufnal
- Academic press:
- PlosONe (year: 2024, volume: 19, pages: e0297474), Publisher: PlosONe
- Status:
- Published
- DOI:
- 10.1371/journal.pone.02974744 – link to the publication
-
Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM‑1 in rats.
- Authors:
- Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś‑Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
- Academic press:
- Journal of Translational Medicine (year: 2022, volume: 20, pages: 46036), Publisher: BMC
- Status:
- Published
- DOI:
- 10.1186/s12967-022-03687-y – link to the publication
-
Urinary excretion of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine is positively related to nitric oxide level in tissues of normotensive and hypertensive rats
- Authors:
- Dominika Szlęzak, Marcin Ufnal, Adrian Drapała, Emilia Samborowska, Maria Wróbel
- Academic press:
- Amino Acids (year: 2023, volume: 111, pages: 46033), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00726-023-03246-9 – link to the publication