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Application of voltammetry and gravimetry for simultaneous detection of matrix metalloproteinases -1, -2 and -9 in human lung cancer

2019/35/B/ST4/02497

Keywords:

matrix metalloproteinases cancer biomarkers electrochemical detection sensor enzyme activity in vivo studies in vitro studies human lung cancer

Descriptors:

  • ST4_005:
  • ST4_007:
  • ST4_009:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Anna Maria Nowicka 

Number of co-investigators in the project: 11

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 239 200 PLN

Project start date (Y-m-d): 2020-07-09

Project end date (Y-m-d): 2023-07-08

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. PAMAM-immunosensor for gravimetric and electrochemical detection of an important cancer biomarker − matrix metalloproteinase-9
    Authors:
    Monika K. Nisiewicz, Małgorzata Sikorska, Agata Kowalczyk, Artur Kasprzak, Magdalena Bamburowicz-Kimkowska, Mariola Koszytkowska-Stawińska, Anna M. Nowicka
    Academic press:
    Talanta , Wydawca: Elsevier
    Status:
    Submitted
  2. Novel electrogravimetric biosensors for the ultrasensitive detection of plasma matrix metalloproteinase-2 considered a potential tumor biomarker
    Authors:
    Monika K. Nisiewicz, Aleksandra Gajda, Agata Kowalczyk, Aleksandra Cupriak, Artur Kasprzak, Magdalena Bamburowicz-Klimkowska, Ireneusz P. Grudzinski, Anna M. Nowicka
    Academic press:
    Analytica Chimica Acta (rok: 2022, tom: 1191, strony: 339290), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.aca.2021.339290 - link to the publication
  3. PAMAM-immunosensor for gravimetric and electrochemical detection of an important cancer biomarker − matrix metalloproteinase-9
    Authors:
    Monika K. Nisiewicz, Małgorzata Sikorska, Agata Kowalczyk, Artur Kasprzak, Magdalena Bamburowicz-Kimkowska, Mariola Koszytkowska-Stawińska, Anna M. Nowicka
    Academic press:
    Talanta , Wydawca: Elsevier
    Status:
    Submitted
  4. Synthesis and structural, electrochemical and photophysical studies of triferrocenyl-substituted 1,3,5-triphenylbenzene: a cyan-light emitting molecule showing aggregation-induced enhanced emission
    Authors:
    Artur Kasprzak, Piotr A. Guńka, Agata Kowalczyk, Anna M. Nowicka
    Academic press:
    Dalton Transactions (rok: 2020, tom: 49, strony: 14807), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0dt02948c - link to the publication
  5. Enzymatic cleavage of specific dipeptide conjugated with ferrocene as a flexible ultra-sensitive and fast voltammetric assay of matrix metalloproteinase-9 considered a prognostic cancer biomarker in plasma samples
    Authors:
    Monika K. Nisiewicz, Agata Kowalczyk, Aleksandra Gajda, Artur Kasprzak, Magdalena Bamburowicz-Klimkowska, Ireneusz P. Grudzinski, Anna M. Nowicka
    Academic press:
    Biosensors and Bioelectronics (rok: 2022, tom: 195, strony: 13653), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2021.113653 - link to the publication
  6. Poly(amidoamine) dendrimer immunosensor for ultrasensitive gravimetric and electrochemical detection of matrix metalloproteinase-9
    Authors:
    Monika K. Nisiewicz, Agata Kowalczyk, Małgorzata Sikorska, Artur Kasprzak, Magdalena Bamburowicz-Klimkowska, Mariola Koszytkowska-Stawińska, Anna M. Nowicka
    Academic press:
    Talanta (rok: 2022, tom: 247, strony: 123600), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.talanta.2022.123600 - link to the publication
  7. Enzymatic cleavage of specific dipeptide conjugated with ferrocene as a flexible ultra-sensitive and fast voltammetric assay of matrix metalloproteinase-9 considered a prognostic cancer biomarker in plasma samples
    Authors:
    Monika K. Nisiewicz, Agata Kowalczyk, Aleksandra Gajda, Artur Kasprzak, Magdalena Bamburowicz-Klimkowska, Ireneusz P. Grudzinski, Anna M. Nowicka
    Academic press:
    Biosensors and Bioelectronics (rok: 2022, tom: 195, strony: 13653), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2021.113653 - link to the publication
  8. Synthesis and structural, electrochemical and photophysical studies of triferrocenyl-substituted 1,3,5-triphenylbenzene: a cyan-light emitting molecule showing aggregation-induced enhanced emission
    Authors:
    Artur Kasprzak, Piotr A. Guńka, Agata Kowalczyk, Anna M. Nowicka
    Academic press:
    Dalton Transactions (rok: 2020, tom: 49, strony: 14807), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0dt02948c - link to the publication
  9. Novel electrogravimetric biosensors for the ultrasensitive detection of plasma matrix metalloproteinase-2 considered a potential tumor biomarker
    Authors:
    Monika K. Nisiewicz, Aleksandra Gajda, Agata Kowalczyk, Aleksandra Cupriak, Artur Kasprzak, Magdalena Bamburowicz-Klimkowska, Ireneusz P. Grudzinski, Anna M. Nowicka
    Academic press:
    Analytica Chimica Acta (rok: 2022, tom: 1191, strony: 339290), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.aca.2021.339290 - link to the publication
  10. A rapid, selective, and ultrasensitive voltammetric and gravimetric protocol for MMP-1 active form detection
    Authors:
    Agata Kowalczyk, Monika K. Nisiewicz, Artur Kasprzak, Magdalena Bamburowicz-Klimkowska, Anna M. Nowicka
    Academic press:
    Journal of Materials Chemistry B (rok: 2022, tom: 10, strony: 8696-8709), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2tb01803a - link to the publication

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