Projects funded by the NCN
Gamma-glutamylcysteine ligase participation in the antioxidant mechanism of action of sulodexide on vascular endothelial cell - the in vitro research
2019/35/N/NZ7/03071
Keywords:
endothelial dysfunction sulodexide gamma-glutamylcysteine ligase
Descriptors:
- NZ7_014:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach
woj. śląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 18 - announced on 2019-09-16
Amount awarded: 69 900 PLN
Project start date (Y-m-d): 2020-08-20
Project end date (Y-m-d): 2023-08-19
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Sulodexide Increases Glutathione Synthesis and Causes Pro-Reducing Shift in Glutathione-Redox State in HUVECs Exposed to Oxygen–Glucose Deprivation: Implication for Protection of Endothelium against Ischemic InjuryAuthors:Klaudia Bontor, Bożena GabryelAcademic press:Molecules (rok: 2022, tom: 27, strony: 45672), Wydawca: MDPIStatus:PublishedDOI:10.3390/molecules27175465 - link to the publication
- Ligaza γ-glutamylocysteiny – od molekularnych mechanizmów regulacji aktywności enzymatycznej do implikacji terapeutycznychAuthors:Bożena Gabryel, Klaudia BontorAcademic press:Postępy Higieny i Medycyny Doświadczalnej (rok: 2021, tom: 75, strony: 823 - 836), Wydawca: SciendoStatus:PublishedDOI:10.2478/ahem-2021-0013 - link to the publication
- Sulodexide protects endothelial cells against 4-hydoxynonenal induced oxidative stress and glutathione-dependent redox imbalance by modulation of sestrin2/nuclear factor erythroid 2-related factor 2 pathwayAuthors:Klaudia Bontor, Bożena GabryelAcademic press:Journal of Physiology and Pharmacology (rok: 2024, tom: 75, strony: 373-387), Wydawca: Polish Physiological SocietyStatus:PublishedDOI:10.26402/jpp.2024.4.03 - link to the publication