Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular mechanisms modulating the function of UCH-L1 deubiquitinase in human mitochondria

2019/35/B/NZ3/04066

Keywords:

mitochondria ubiquitin proteasome neurodegeneration

Descriptors:

  • NZ3_001:
  • NZ3_002:
  • NZ1_002:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Małgorzata Chacińska 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 912 160 PLN

Project start date (Y-m-d): 2020-12-08

Project end date (Y-m-d): 2025-12-07

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Methods to monitor mitochondrial disulfide bonds.
    Authors:
    Mussulini, B. H. M., Wasilewski, M., & Chacinska, A.
    Academic press:
    Methods in enzymology (rok: 2024, tom: 706, strony: 125–158), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.mie.2024.07.039 - link to the publication
  2. Protein import into mitochondria - a new path through the membranes
    Authors:
    Wasilewski, M., Draczkowski, P., & Chacinska, A.
    Academic press:
    Nature structural & molecular biology (rok: 2023, tom: 30, strony: 1831–1833), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41594-023-01170-w - link to the publication
  3. Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction
    Authors:
    Kim, M., Serwa, R. A., Samluk, L., Suppanz, I., Kodroń, A., Stępkowski, T. M., Elancheliyan, P., Tsegaye, B., Oeljeklaus, S., Wasilewski, M., Warscheid, B., & Chacinska, A.
    Academic press:
    Nature Communications (rok: 2023, tom: 14, strony: 45680), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-023-39642-8 - link to the publication
  4. Protein import into mitochondria - a new path through the membranes
    Authors:
    Wasilewski, M., Draczkowski, P., & Chacinska, A.
    Academic press:
    Nature structural & molecular biology (rok: 2023, tom: 30, strony: 1831–1833), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41594-023-01170-w - link to the publication
  5. OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase.
    Authors:
    Elancheliyan, P., Maruszczak, K. K., Serwa, R. A., Stephan, T., Gulgec, A. S., Borrero-Landazabal, M. A., Ngati, S., Gosk, A., Jakobs, S., Wasilewski, M., & Chacinska, A.
    Academic press:
    Cell reports (rok: 2024, tom: 43(12), strony: 115038), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2024.115038 - link to the publication
  6. OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase.
    Authors:
    Elancheliyan, P., Maruszczak, K. K., Serwa, R. A., Stephan, T., Gulgec, A. S., Borrero-Landazabal, M. A., Ngati, S., Gosk, A., Jakobs, S., Wasilewski, M., & Chacinska, A.
    Academic press:
    Cell reports (rok: 2024, tom: 43(12), strony: 115038), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2024.115038 - link to the publication
  7. Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction
    Authors:
    Kim, M., Serwa, R. A., Samluk, L., Suppanz, I., Kodroń, A., Stępkowski, T. M., Elancheliyan, P., Tsegaye, B., Oeljeklaus, S., Wasilewski, M., Warscheid, B., & Chacinska, A.
    Academic press:
    Nature Communications (rok: 2023, tom: 14, strony: 45680), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-023-39642-8 - link to the publication
  8. Defective mitochondrial import as a challenge for cellular protein homeostasis
    Authors:
    Maruszczak, K. K., Ayyamperumal, S., & Chacinska, A.
    Academic press:
    FEBS letters (rok: 2023, tom: 597, strony: 1555–1568), Wydawca: FEBS Press
    Status:
    Published
    DOI:
    10.1002/1873-3468.14677 - link to the publication
  9. Methods to monitor mitochondrial disulfide bonds.
    Authors:
    Mussulini, B. H. M., Wasilewski, M., & Chacinska, A.
    Academic press:
    Methods in enzymology (rok: 2024, tom: 706, strony: 125–158), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.mie.2024.07.039 - link to the publication

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