Projects funded by the NCN
Targeting senescent brain cells to improve cognitive function in animal models of ageing and depression
2019/35/B/NZ4/01920
Keywords:
ageing cell senescence brain dendritic tree depression neural cell plastycity spatial memory
Descriptors:
- NZ3_004:
- NZ4_007:
- NZ3_003:
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 9
Call: OPUS 18 - announced on 2019-09-16
Amount awarded: 2 130 720 PLN
Project start date (Y-m-d): 2020-07-20
Project end date (Y-m-d): 2024-07-19
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (5)
- Guidelines for minimal information on cellular senescence experimentation in vivo.Authors:Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M.Academic press:Cell (rok: 2024, tom: 2024 Aug 8;187(16), strony: 4150-4175), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.cell.2024.05.059 - link to the publication
- Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profileAuthors:Krzystyniak A, Wesierska M, Petrazzo G, Gadecka A, Dudkowska M, Bielak- Zmijewska A, Mosieniak G, Figiel I, Wlodarczyk J, Sikora EAcademic press:Aging (rok: 2022, tom: 14(2):, strony: 572-595), Wydawca: Aging (Albany NY)Status:PublishedDOI:10.18632/aging.203835 - link to the publication
- Fiji-Based Tool for Rapid and Unbiased Analysis of SA-β-Gal Activity in Cultured Cells.Authors:Krzystyniak A, Gluchowska A, Mosieniak G, Sikora E. Fiji-Based Tool for Rapid and Unbiased Analysis of SA-β-Gal Activity in Cultured CellsAcademic press:Biomolecules (rok: 2023, tom: 13(2), strony: 362), Wydawca: MDPIStatus:PublishedDOI:10.3390/biom13020362 - link to the publication
- 2-Bromopalmitate treatment attenuates senescence phenotype in human adult cells - possible role of palmitoylation.Authors:Krzystyniak A, Gluchowska A, Pytyś A, Dudkowska M, Wójtowicz T, Targonska A, Janiszewska D, Sikora E, MosieniakAcademic press:Aging (Albany NY) (rok: 2024, tom: 2024 Aug 23;16, strony: 16), Wydawca: Impact Journals, LLCStatus:PublishedDOI:10.18632/aging.206080 - link to the publication
- Cellular Senescence in Brain AgingAuthors:Ewa Sikora, Anna Bielak-Zmijewska, Magdalena Dudkowska, Adam Krzystyniak, Grazyna Mosieniak, Malgorzata Wesierska, Jakub WlodarczykAcademic press:Frontiers in Aging Neuroscience (rok: 2021, tom: 13, strony: 45680), Wydawca: FrontiersStatus:PublishedDOI:10.3389/fnagi.2021.646924 - link to the publication