Projects funded by the NCN

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Information of the project and the call

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Mechanism of regulation glycosaminoglycan levels by resveratrol in a mouse model of a neuronopathic disease from the mucopolysaccharidosis group

2019/35/N/NZ2/00505

Keywords:

mucopolysaccharidosis resveratrol glycosaminoglycans degradation of glycosaminoglycans autophagy

Descriptors:

  • NZ2_001:
  • NZ4_007:
  • NZ3_005:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Estera Elmira Rintz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2020-06-18

Project end date (Y-m-d): 2024-06-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Activities of (Poly)phenolic Antioxidants and Other Natural Autophagy Modulators in the Treatment of Sanfilippo Disease: Remarkable Efficacy of Resveratrol in Cellular and Animal Models
    Authors:
    Estera Rintz, Magdalena Podlacha, Zuzanna Cyske, Karolina Pierzynowska, Grzegorz Węgrzyn, Lidia Gaffke
    Academic press:
    Journal of the American Society for Experimental NeuroTherapeutics (rok: 2022, tom: 20, strony: 254–271), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13311-022-01323-7 - link to the publication
  2. Has resveratrol a potential for mucopolysaccharidosis treatment?
    Authors:
    Estera Rintz, Karolina Pierzynowska, Magdalena Podlacha, Grzegorz Węgrzyn
    Academic press:
    European journal of pharmacology (rok: 2020, tom: 888, strony: 173534), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173534 - link to the publication
  3. Has resveratrol a potential for mucopolysaccharidosis treatment?
    Authors:
    Estera Rintz, Karolina Pierzynowska, Magdalena Podlacha, Grzegorz Węgrzyn
    Academic press:
    European journal of pharmacology (rok: 2020, tom: 888, strony: 173534), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173534 - link to the publication
  4. Synergistic Effects of Resveratrol and Enzyme Replacement Therapy in the Mucopolysaccharidosis Type I
    Authors:
    Estera Rintz, Maja Ziemian, Barbara Kobus, Lidia Gaffke, Karolina Pierzynowska, Grzegorz Węgrzyn
    Academic press:
    Biochemical Pharmacology (rok: 2024, tom: 229, strony: 116467), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2024.116467 - link to the publication
  5. Activities of (Poly)phenolic Antioxidants and Other Natural Autophagy Modulators in the Treatment of Sanfilippo Disease: Remarkable Efficacy of Resveratrol in Cellular and Animal Models
    Authors:
    Estera Rintz, Magdalena Podlacha, Zuzanna Cyske, Karolina Pierzynowska, Grzegorz Węgrzyn, Lidia Gaffke
    Academic press:
    Journal of the American Society for Experimental NeuroTherapeutics (rok: 2022, tom: -, strony: -), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13311-022-01323-7 - link to the publication
  6. Has resveratrol a potential for mucopolysaccharidosis treatment?
    Authors:
    Estera Rintz, Karolina Pierzynowska, Magdalena Podlacha, Grzegorz Węgrzyn
    Academic press:
    European journal of pharmacology (rok: 2020, tom: 888, strony: 173534), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173534 - link to the publication
  7. Has resveratrol a potential for mucopolysaccharidosis treatment?
    Authors:
    Estera Rintz, Karolina Pierzynowska, Magdalena Podlacha, Grzegorz Węgrzyn
    Academic press:
    European journal of pharmacology (rok: 2020, tom: 888, strony: 173534), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173534 - link to the publication
  8. Causes of death in mucopolysaccharidoses
    Authors:
    Estera Rintz , Marcin Banacki , Maja Ziemian , Barbara Kobus , Grzegorz Wegrzyn
    Academic press:
    Molecular Genetics and Metabolism (rok: 2024, tom: 142, strony: 108507), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymgme.2024.108507 - link to the publication
  9. Activities of (Poly)phenolic Antioxidants and Other Natural Autophagy Modulators in the Treatment of Sanfilippo Disease: Remarkable Efficacy of Resveratrol in Cellular and Animal Models
    Authors:
    Estera Rintz, Magdalena Podlacha, Zuzanna Cyske, Karolina Pierzynowska, Grzegorz Węgrzyn, Lidia Gaffke
    Academic press:
    Journal of the American Society for Experimental NeuroTherapeutics (rok: 2022, tom: -, strony: -), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13311-022-01323-7 - link to the publication

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