Mitochondrial import pathways of viral proteins

2019/35/B/NZ3/04095

Keywords

Descriptors

  • NZ3_001: Biologia komórki
  • NZ1_001: Biologia molekularna
  • NZ6_005: Wirusologia

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Michał Szymon Wasilewski

Number of co-investigators in the project: 4

Call

OPUS 18 – announced on 2019-09-16

Amount awarded
2 537 400 PLN
Project start date
2020-11-25
Project end date
2026-11-24
Project duration
72 months (the same as in the proposal)
Project status
Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (6)

  1. OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

    Authors:
    Elancheliyan P, Maruszczak KK, Serwa RA, Stephan T, Gulgec SA, Borrero-Landazabal MA, Ngati S, Gosk A, Jakobs S, Wasilewski M, Chacinska A
    Academic press:
    Cell Reports (year: 2024, volume: 43(12), pages: 115038), Publisher: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2024.115038 – link to the publication
  2. Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction

    Authors:
    Kim M, Serwa RA, Samluk L, Suppanz I, Kodroń A, Stępkowski TM, Elancheliyan P, Tsegaye B, Oeljeklaus S, Wasilewski M, Warscheid B, Chacinska A
    Academic press:
    Nature Communications (year: 2023, volume: 14, pages: 4092), Publisher: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-023-39642-8 – link to the publication
  3. MIC60 relays oxidation to block mitophagy

    Authors:
    Wasilewski M, Chacinska A
    Academic press:
    Nature Metabolism (year: 2021, volume: 3(9), pages: 1146-1147), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s42255-021-00460-1 – link to the publication
  4. Protein import into mitochondria—a new path through the membranes

    Authors:
    Wasilewski M, Draczkowski P, Chacinska A
    Academic press:
    Nature Structural & Molecular Biology (year: 2023, volume: 30, pages: 1831-1833), Publisher: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41594-023-01170-w – link to the publication
  5. MIA40 suppresses cell death induced by apoptosis-inducing factor 1

    Authors:
    Mussulini BHM, Maruszczak KK, Draczkowski P, Borrero-Landazabal MA, Ayyamperumal S, Wnorowski A, Wasilewski M, Chacinska A
    Academic press:
    EMBO Reports (year: 2025, volume: 26, pages: 1835-1862), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s44319-025-00406-8 – link to the publication
  6. MitoRUSH as a tool to study the efficiency of mitochondrial import in complex I-deficient cells

    Authors:
    Wasilewski M, Mohanraj K, Zakrzewski M, Serwa RA, Chacinska A
    Academic press:
    Journal of Cell Science (year: 2025, volume: 138(13), pages: jcs263701), Publisher: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/jcs.263701 – link to the publication

Book publications / chapters in book publications (1)

  1. Methods to monitor mitochondrial disulfide bonds

    Authors:
    Mussulini BHM, Wasilewski M, Chacinska A
    Book:
    Methods in Enzymology (year: 2024, volume: 706, pages: 125-158), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.mie.2024.07.039 – link to the publication

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Graphic design and implementation: Jakub Piotrowski