Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The KLIKK proteases of human pathogen Tannerella forsythia: putative virulence factors with unique biochemical and structural properties

2019/35/B/NZ1/03118

Keywords:

enzyme protease proteolysis crystal structure Tannerella forsythia periodontitis

Descriptors:

  • NZ1_002:
  • NZ1_004:
  • NZ1_010:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Mirosław Książek 

Number of co-investigators in the project: 2

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 721 952 PLN

Project start date (Y-m-d): 2020-07-10

Project end date (Y-m-d): 2024-07-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (15)
  1. Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors
    Authors:
    Schmitz C, Madej M, Nowakowska Z, Cuppari A, Jacula A, Ksiazek M, Mikruta K, Wisniewski J, Pudelko-Malik N, Saran A, Zeytuni N, Mlynarz P, Lamont RJ, Usón I, Siksnys V, Potempa J, Solà M
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 50(21), strony: 12558-12577), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac1103 - link to the publication
  2. Phage display selection of human single domain antibodies towards karilysin, a metalloproteinase and secreted virulence factor from Tannerella forsythia
    Authors:
    Skottrup PD, Książek M, Potempa J
    Academic press:
    Journal of Immunological Methods (rok: 2023, tom: 516, strony: 113458), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jim.2023.113458 - link to the publication
  3. Identification and characterization of aptameric inhibitors of human neutrophil elastase
    Authors:
    Malicki S, Książek M, Sochaj Gregorczyk A, Kamińska M, Golda A, Chruścicka B, Mizgalska D, Potempa J, Marti HP, Kozieł J, Wieczorek M, Pieczykolan J, Mydel P, Dubin G.
    Academic press:
    The Journal of biological chemistry (rok: 2023, tom: 299(8), strony: 104889), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbc.2023.104889 - link to the publication
  4. Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.
    Authors:
    Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M.
    Academic press:
    The Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2021, tom: 36(1), strony: 1267-1281), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2021.1937619 - link to the publication
  5. Identification and characterization of aptameric inhibitors of human neutrophil elastase
    Authors:
    Malicki S, Książek M, Sochaj Gregorczyk A, Kamińska M, Golda A, Chruścicka B, Mizgalska D, Potempa J, Marti HP, Kozieł J, Wieczorek M, Pieczykolan J, Mydel P, Dubin G.
    Academic press:
    The Journal of biological chemistry (rok: 2023, tom: 299(8), strony: 104889), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbc.2023.104889 - link to the publication
  6. Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors
    Authors:
    Schmitz C, Madej M, Nowakowska Z, Cuppari A, Jacula A, Ksiazek M, Mikruta K, Wisniewski J, Pudelko-Malik N, Saran A, Zeytuni N, Mlynarz P, Lamont RJ, Usón I, Siksnys V, Potempa J, Solà M
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 50(21), strony: 12558-12577), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac1103 - link to the publication
  7. Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.
    Authors:
    Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M.
    Academic press:
    The Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2021, tom: 36(1), strony: 1267-1281), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2021.1937619 - link to the publication
  8. Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.
    Authors:
    Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M.
    Academic press:
    The Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2021, tom: 36(1), strony: 1267-1281), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2021.1937619 - link to the publication
  9. Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia.
    Authors:
    Zak KM, Bostock MJ, Waligorska I, Thøgersen IB, Enghild JJ, Popowicz GM, Grudnik P, Potempa J, Ksiazek M.
    Academic press:
    The Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2021, tom: 36(1), strony: 1267-1281), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2021.1937619 - link to the publication
  10. Phage display selection of human single domain antibodies towards karilysin, a metalloproteinase and secreted virulence factor from Tannerella forsythia
    Authors:
    Skottrup PD, Książek M, Potempa J
    Academic press:
    Journal of Immunological Methods (rok: 2023, tom: 516, strony: 113458), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jim.2023.113458 - link to the publication
  11. A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
    Authors:
    Książek M, Goulas T, Mizgalska D, Rodríguez-Banqueri A, Eckhard U, Veillard F, Waligórska I, Benedyk-Machaczka M, Sochaj-Gregorczyk AM, Madej M, Thøgersen IB, Enghild JJ, Cuppari A, Arolas JL, de Diego I, López-Pelegrín M, Garcia-Ferrer I, Guevara T, Dive V, Zani ML, Moreau T, Potempa J, Gomis-Rüth FX
    Academic press:
    Chemical Science (rok: 2022, tom: 14(4), strony: 869-888), Wydawca: Royal Society of Chemistry (United Kingdom)
    Status:
    Published
    DOI:
    10.1039/D2SC04166A - link to the publication
  12. A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
    Authors:
    Książek M, Goulas T, Mizgalska D, Rodríguez-Banqueri A, Eckhard U, Veillard F, Waligórska I, Benedyk-Machaczka M, Sochaj-Gregorczyk AM, Madej M, Thøgersen IB, Enghild JJ, Cuppari A, Arolas JL, de Diego I, López-Pelegrín M, Garcia-Ferrer I, Guevara T, Dive V, Zani ML, Moreau T, Potempa J, Gomis-Rüth FX
    Academic press:
    Chemical Science (rok: 2022, tom: 14(4), strony: 869-888), Wydawca: Royal Society of Chemistry (United Kingdom)
    Status:
    Published
    DOI:
    10.1039/D2SC04166A - link to the publication
  13. Structural and functional insights into the C-terminal signal domain of the Bacteroidetes type-IX secretion system.
    Authors:
    Mizgalska D, Rodríguez-Banqueri A, Veillard F, Książęk M, Goulas T, Guevara T, Eckhard U, Potempa J, Gomis-Rüth FX.
    Academic press:
    Open Biology (rok: 2024, tom: 14(6), strony: 230448), Wydawca: THE ROYAL SOCIETY PUBLISHING
    Status:
    Published
    DOI:
    10.1098/rsob.230448 - link to the publication
  14. A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
    Authors:
    Książek M, Goulas T, Mizgalska D, Rodríguez-Banqueri A, Eckhard U, Veillard F, Waligórska I, Benedyk-Machaczka M, Sochaj-Gregorczyk AM, Madej M, Thøgersen IB, Enghild JJ, Cuppari A, Arolas JL, de Diego I, López-Pelegrín M, Garcia-Ferrer I, Guevara T, Dive V, Zani ML, Moreau T, Potempa J, Gomis-Rüth FX
    Academic press:
    Chemical Science (rok: 2022, tom: 14(4), strony: 869-888), Wydawca: Royal Society of Chemistry (United Kingdom)
    Status:
    Published
    DOI:
    10.1039/D2SC04166A - link to the publication
  15. Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors
    Authors:
    Schmitz C, Madej M, Nowakowska Z, Cuppari A, Jacula A, Ksiazek M, Mikruta K, Wisniewski J, Pudelko-Malik N, Saran A, Zeytuni N, Mlynarz P, Lamont RJ, Usón I, Siksnys V, Potempa J, Solà M
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 50(21), strony: 12558-12577), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac1103 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy