Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Modified glycosaminoglycans as nanocarriers of bioactive substances

2019/35/B/ST5/02147

Keywords:

polysaccharides polymeric nanoparticles drug delivery systems lipid membranes molecular dynamics simulations TEM microscopy,

Descriptors:

  • ST5_009:
  • ST5_010:
  • ST5_011:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Mariusz Kępczyński 

Number of co-investigators in the project: 7

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 933 132 PLN

Project start date (Y-m-d): 2020-07-20

Project end date (Y-m-d): 2024-07-19

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Ultrasound-assisted preparation of hyaluronic acid-based nanocapsules with an oil core
    Authors:
    Natan Rajtar, Grzegorz Łazarski, Aleksander Foryś, Łukasz Otulakowski, Barbara Trzebicka, Dorota Jamróz, Mariusz Kepczynski
    Academic press:
    Materials (rok: 2024, tom: 17, strony: 4524), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma17184524 - link to the publication
  2. Kartogenin-loaded liposomes coated with alkylated chondroitin sulfate for cartilage repair
    Authors:
    Magdalena Wytrwal, Katarzyna Szmajnta, Miroslaw Kucharski, Jakub Nowak, Ewa Oclon, Mariusz Kepczynski
    Academic press:
    International Journal of Pharmaceutics (rok: 2023, tom: 646, strony: 123436), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2023.123436 - link to the publication
  3. Effect of polycation nanostructures on cell membrane permeability and toxicity
    Authors:
    Magdalena Wytrwal-Sarna, Paulina Knobloch, Sławomir Lasota, Marta Michalik, Maria Nowakowska, Mariusz Kepczynski
    Academic press:
    Environmental Science Nano (rok: 2022, tom: 9, strony: 702–713), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1EN01156A - link to the publication
  4. Molecular insights into the self-assembly of hydrophobically modified chondroitin sulfate in aqueous media
    Authors:
    Agata Żak, Grzegorz Łazarski, Magdalena Wytrwal-Sarna, Dorota Jamróz, Magdalena Górniewicz, Aleksander Foryś, Barbara Trzebicka, Mariusz Kepczynski
    Academic press:
    Carbohydrate Polymers (rok: 2022, tom: 297, strony: 119999), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.carbpol.2022.119999 - link to the publication
  5. Deciphering Lipid Arrangement in Phosphatidylserine/ Phosphatidylcholine Mixed Membranes: Simulations and Experiments
    Authors:
    Agata Żak, Ksenia Korshunova, Natan Rajtar, Waldemar Kulig, Mariusz Kepczynski
    Academic press:
    Langmuir (rok: 2023, tom: 39, strony: 18995–19007), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.3c03061 - link to the publication
  6. Miscibility of Phosphatidylcholines in Bilayers: Effect of Acyl Chain Unsaturation
    Authors:
    Agata Zak, Natan Rajtar, Waldemar Kulig, Mariusz Kepczynski
    Academic press:
    Membranes (rok: 2023, tom: 13, strony: 411), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes13040411 - link to the publication
  7. Chondroitin Sulfate-Based Nanocapsules as Nanocarriers for Drugs and Nutraceutical Supplements
    Authors:
    Magdalena Górniewicz, Dawid Wnuk, Aleksander Foryś, Barbara Trzebicka, Marta Michalik, Mariusz Kepczynski
    Academic press:
    International Journal o f Molecular Sciences (rok: 2024, tom: 25, strony: 5897), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25115897 - link to the publication
  8. Interaction of chondroitin sulfate with zwitterionic lipid membranes
    Authors:
    Grzegorz Łazarski, Natan Rajtar, Agata Żak, Dorota Jamróz, Mariusz Kepczynski
    Academic press:
    Chemistry and Physics of Lipids (rok: 2024, tom: 263, strony: 105417), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.chemphyslip.2024.105417 - link to the publication
  9. Ultrasound-assisted preparation of hyaluronic acid-based nanocapsules with an oil core
    Authors:
    Natan Rajtar, Grzegorz Łazarski, Aleksander Foryś, Łukasz Otulakowski, Barbara Trzebicka, Dorota Jamróz, Mariusz Kepczynski
    Academic press:
    Materials (rok: 2024, tom: 17, strony: 4524), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma17184524 - link to the publication
  10. Kartogenin-loaded liposomes coated with alkylated chondroitin sulfate for cartilage repair
    Authors:
    Magdalena Wytrwal, Katarzyna Szmajnta, Miroslaw Kucharski, Jakub Nowak, Ewa Oclon, Mariusz Kepczynski
    Academic press:
    International Journal of Pharmaceutics (rok: 2023, tom: 646, strony: 123436), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2023.123436 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy