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Investigation of the effectiveness and mechanisms of fungicidal activity of selected 1,3,4-thiadiazoles derivatives in interaction with antibiotics from the azole and polyene group against strains with specific or multidrug resistance

2019/35/B/NZ7/02756

Keywords:

1,3,4-thiadiazole derivatives multidrug resistance Candida FTIR amphotericin B azoles,

Descriptors:

  • NZ7_014:
  • NZ1_010:
  • NZ7_001:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Chemii

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Gagoś 

Number of co-investigators in the project: 15

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 792 675 PLN

Project start date (Y-m-d): 2020-09-01

Project end date (Y-m-d): 2024-08-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  1. Cooperativity of ESPT and Aggregation-Induced Emission Effects—An Experimental and Theoretical Analysis of a 1,3,4-Thiadiazole Derivative
    Authors:
    Iwona Budziak-Wieczorek, Dominika Kaczmarczyk, Klaudia Rząd , Mariusz Gagoś, Andrzej Stepulak , Beata Myśliwa-Kurdziel , Dariusz Karcz , Karolina Starzak , Gotard Burdzi ński ,Monika Srebro-Hooper, Arkadiusz Matwijczuk
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 3352), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25063352 - link to the publication
  2. Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
    Authors:
    Magdalena Kimsa-Dudek, Celina Kruszniewska-Rajs, Jolanta Adamska, Barbara Strzałka-Mrozik, Arkadiusz Matwijczuk, Dariusz Karcz, Mariusz Gagoś, Joanna Magdalena Gola
    Academic press:
    Pharmacological Reports (rok: 2024, tom: 76(3), strony: 557-571), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-024-00592-7 - link to the publication
  3. Effect of Antibiotic Amphotericin B Combinations with Selected 1,3,4-Thiadiazole Derivatives on RPTECs in an In Vitro Model
    Authors:
    Agnieszka Dróżdż, Adrianna Sławińska-Brych, Dominika Kubera, Magdalena Kimsa-Dudek, Joanna Magdalena Gola, Jolanta Adamska, Celina Kruszniewska-Rajs, Arkadiusz Matwijczuk, Dariusz Karcz, Wojciech Dąbrowski , Andrzej Stepulak and Mariusz Gagoś
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 15260), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232315260 - link to the publication
  4. Novel Coumarin‐Thiadiazole Hybrids and Their Cu(II) and Zn(II) Complexes as Potential Antimicrobial Agents and Acetylcholinesterase Inhibitors
    Authors:
    Dariusz Karcz, Karolina Starzak, Ewa Ciszkowicz, Katarzyna Lecka-Szlachta, Daniel Kamiński, Bernadette Creaven, Hollie Jenkins, Piotr Radomski, Anna Miłoś, Lidia Ślusarczyk, Arkadiusz Matwijczuk
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 9709 - 9732), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189709 - link to the publication
  5. Synergistic Antifungal Interactions between Antibiotic Amphotericin B and Selected 1,3,4-thiadiazole Derivatives, Determined by Microbiological, Cytochemical, and Molecular Spectroscopic Studies
    Authors:
    Agnieszka Dróżdż, Dominika Kubera, Adrianna Sławińska-Brych, Arkadiusz Matwijczuk, Lidia Ślusarczyk, Grzegorz Czernel, Dariusz Karcz, Alina Olender, Agnieszka Bogut, Daniel Pietrzak, Wojciech Dąbrowski, Andrzej Stepulak, Alicja Wójcik-Załuska, Mariusz Gagoś
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(4), strony: nr artykułu 3430), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24043430 - link to the publication
  6. Biodirected Synthesis of Silver Nanoparticles Using Aqueous Honey Solutions and Evaluation of Their Antifungal Activity against Pathogenic Candida Spp.
    Authors:
    Grzegorz Czernel, Dominika Bloch, Arkadiusz Matwijczuk, Jolanta Cieśla, Monika Kędzierska- Matysek, Mariusz Florek, Mariusz Gagoś
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 7715 - 7730), Wydawca: International Journal of Molecular Sciences
    Status:
    Published
    DOI:
    10.3390/ijms22147715 - link to the publication
  7. Insight into dual fluorescence effects induced by molecular aggregation occurring in membrane model systems containing 1,3,4‐thiadiazole derivatives
    Authors:
    Melinda David, Iwona Budziak Wieczorek, Dariusz Karcz, Monica Florescu, Arkadiusz Matwijczuk
    Academic press:
    European Biophysics Journal (rok: 2021, tom: 50, strony: 1083–1101), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00249-021-01569-7 - link to the publication
  8. ESIPT-Related Origin of Dual Fluorescence in the Selected Model 1,3,4-Thiadiazole Derivatives.
    Authors:
    Grzegorz Czernel, Iwona Budziak, Anna Oniszczuk, Dariusz Karcz, Katarzyna Pustuła, Andrzej Górecki, Alicja Matwijczuk, Bożena Gładyszewska, Mariusz Gagoś , Andrzej Niewiadomy, Arkadiusz Matwijczuk
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4168), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25184168 - link to the publication
  9. Candida Auris: co wiemy na temat najbardziej enigmatycznego patogenu XXI wieku?
    Authors:
    Agnieszka Bogut
    Academic press:
    Postępy Mikrobiologii (rok: 2023, tom: 62 nr 1, strony: 27-46), Wydawca: Polskie Towarzystwo Mikrobiologów
    Status:
    Published
    DOI:
    10.2478/am-2023-0003 - link to the publication
  10. Spectroscopic characterization and assessment of microbiological potential of 1,3,4-thiadiazole derivative showing ESIPT dual fluorescence enhanced by aggregation effects
    Authors:
    Iwona Budziak-Wieczorek, Lidia Ślusarczyk, Beata Myśliwa-Kurdziel, Martyna Kurdziel, Monika Srebro Hooper, Izabela Korona-Głowniak, Mariusz Gagoś, Grzegorz Gładyszewski, Andrzej Stepulak, Dariusz Kluczyk, Arkadiusz Matwijczuk
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 22140), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1038/s41598-022-26690-1 - link to the publication
  11. Effect of Antibiotic Amphotericin B Combinations with Selected 1,3,4-Thiadiazole Derivatives on RPTECs in an In Vitro Model
    Authors:
    Agnieszka Dróżdż, Adrianna Sławińska-Brych, Dominika Kubera, Magdalena Kimsa-Dudek, Joanna Magdalena Gola, Jolanta Adamska, Celina Kruszniewska-Rajs, Arkadiusz Matwijczuk, Dariusz Karcz, Wojciech Dąbrowski , Andrzej Stepulak and Mariusz Gagoś
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 15260), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232315260 - link to the publication

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