Exploring the role and therapeutic potential of sex hormone binding globulin (SHBG) in the course of insulin resistance, inflammation, lipotoxicity in adipose stem progenitor cells and adipocytes in equine metabolic syndrome (EMS) mares.
2019/35/B/NZ7/03651
Keywords
Descriptors
- NZ7_013: Prewencja chorób zwierząt
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Przyrodniczy we Wrocławiu, Wydział Biologii i Hodowli Zwierząt
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
prof. Krzysztof Mariusz Marycz
Number of co-investigators in the project: 7
Call
OPUS 18 – announced on 2019-09-16
- Amount awarded
- 2 212 920 PLN
- Project start date
- 2020-08-03
- Project end date
- 2023-12-02
- Project duration
- 40 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (6)
-
Sex hormone-binding globulin (SHBG) maintains proper equine adipose-derived stromal cells (ASCs)' metabolic functions and negatively regulates their basal adipogenic potential
- Authors:
- Bourebaba L., Zyzak M., Sikora M., Serwotka-Suszczak A., Mularczyk M., Al Naem M., Marycz K.
- Academic press:
- Stem Cell Reviews and Reports (year: 2023, volume: 19, pages: 2251–2273), Publisher: Springer Science+Business Media
- Status:
- Published
- DOI:
- 10.1007/s12015-023-10580-8 – link to the publication
-
Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment
- Authors:
- Bourebaba N., Ngoa TH, Smieszek A., Bourebaba L., Marycz K.
- Academic press:
- Biomedicine & Pharmacotherapy (year: 2022, volume: 153, pages: 113261), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.biopha.2022.113261 – link to the publication
-
The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome - Novel Concept and Therapeutic Implications
- Authors:
- Marycz, K., Kornicka-Garbowska, K., Galuppo, L., & Bourebaba, L.
- Academic press:
- Stem Cell Reviews and Reports (year: 2021, volume: 2021, pages: 46028), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1007/s12015-021-10304-w – link to the publication
-
Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses
- Authors:
- Bourebaba N., Sikora M., Qasem B., Bourebaba L., Marycz K.
- Academic press:
- Cell Communication and Signaling (year: 2023, volume: 21, pages: 230), Publisher: BioMed Central
- Status:
- Published
- DOI:
- 10.1186/s12964-023-01254-6 – link to the publication
-
Sex hormone-binding globulin improves lipid metabolism and reduces inflammation in subcutaneous adipose tissue of metabolic syndrome-affected horses
- Authors:
- Bourebaba L., Kępska M., Qasem B., Zyzak M., Łyczko J., Klemens M., Mularczyk M., Marycz K.
- Academic press:
- Frontiers in Molecular Biosciences (year: 2023, volume: 10, pages: -), Publisher: Frontiers Media SA
- Status:
- Published
- DOI:
- 10.3389/fmolb.2023.1214961 – link to the publication
-
Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in PPARγ-depleted equine adipose derived stromal cells
- Authors:
- Marycz K., Wiatrak B., Irwin-Houston J.M., Marcinkowska K., Mularczyk M., Bourebaba L.
- Academic press:
- Journal of Molecular Medicine (year: 2024, volume: -, pages: 46044), Publisher: Springer Science+Business Media
- Status:
- Published
- DOI:
- 10.1007/s00109-024-02459-z – link to the publication