Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of mitochondria in the pathomechanism of autism-associated neurodevelopmental disorders.

2019/35/B/NZ4/04355

Keywords:

synapse mitochondria fragile X syndrome TRAP1 autism

Descriptors:

  • NZ4_007:
  • NZ4_011:
  • NZ5_003:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Kinga Dziembowska 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 394 240 PLN

Project start date (Y-m-d): 2020-07-20

Project end date (Y-m-d): 2025-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Mutation in mitochondrial chaperone TRAP1 results in male-specific autism
    Authors:
    Małgorzata Rydzanicz, Bozena Kuzniewska, Marta Magnowska, Tomasz Wójtowicz, Ewa Borsuk, Olga Gewartowska, Jakub Gruchota, Anna Hojka, Jacek Miłek, Aleksandra Stawikowska, Patrycja Wardaszka, Izabela Chojnicka, Ludwika Kondrakiewicz, Alicja Puścian, Ewelina Knapska, Andrzej Dziembowski, Rafał Płoski, Magdalena Dziembowska
    Academic press:
    BioRxiv (rok: 2023, tom: none, strony: none), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/2023.06.02.543381 - link to the publication
  2. Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome
    Authors:
    Magdalena Chojnacka 1, Anna Beroun 2, Marta Magnowska 1, Aleksandra Stawikowska 1, Dominik Cysewski 3, Jacek Milek 1, Magdalena Dziembowska 1, Bozena Kuzniewska 1
    Academic press:
    Front Mol Neurosci . (rok: 2023, tom: 2023 Nov 9, strony: 2023 Nov 9:16:1258615), Wydawca: Frontieres
    Status:
    Published
    DOI:
    10.3389/fnmol.2023.1258615 - link to the publication

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