Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Advanced Parental Age (APA) and Assisted Reproduction Technologies (ART): risk evaluation for neurodevelopmental disorders in three generations of offspring.

2019/35/B/NZ4/03547

Keywords:

advanced parental age intra cytoplasmic sperm injection (ICSI) autistic spectrum disorders

Descriptors:

  • NZ4_007:
  • NZ2_002:
  • NZ3_013:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grażyna Ewa Ptak 

Number of co-investigators in the project: 5

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 041 270 PLN

Project start date (Y-m-d): 2020-07-27

Project end date (Y-m-d): 2024-07-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (22)
  • Book publications / chapters in book publications (1)
  1. Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
    Authors:
    Federica Zacchini, Maria Florencia Heber, Roberta Arena, Natalia Radczuk, Urszula Jankowska, Grażyna Ewa Ptak
    Academic press:
    Theriogenology (rok: 2021, tom: 171, strony: 119-129), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2021.05.022 - link to the publication
  2. Ribosomal DNA methylation in human and mouse oocytes increases with age.
    Authors:
    Potabattula R, Trapphoff T, Dittrich M, Fic K, Ptak GE, Dieterle S, Haaf T.
    Academic press:
    Aging (rok: 2022, tom: 14(3), strony: 1214—1232), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/aging.203891 - link to the publication
  3. Lipid droplets in mammalian eggs are utilized during embryonic diapause
    Authors:
    Roberta Arena, Simona Bisogno, Łukasz Gąsior, Joanna Rudnicka, Laura Bernhardt, Thomas Haaf, Federica Zacchini, Michał Bochenek, Kinga Fic, Ewelina Bik, Małgorzata Barańska, Anna Bodzoń-Kułakowska, Piotr Suder, Joanna Depciuch, Artur Gurgul, Zbigniew Polański, Grażyna E. Ptak
    Academic press:
    PNAS (rok: 2021, tom: 118(10), strony: ), Wydawca: National Academy of Sciences of the United States of America
    Status:
    Published
    DOI:
    10.1073/pnas.2018362118 - link to the publication
  4. Późne rodzicielstwo i rozród wspomagany: analiza ryzyka wystąpienia chorób przewlekłych u potomstwa
    Authors:
    Maria Florencia Heber, Hafsa Gulzar, Richard Musson, Simona Bisogno, Kinga Fic, Grażyna Ewa Ptak
    Academic press:
    Postępy biochemii (rok: 2022, tom: Tom 68 nr 3, strony: 321-335), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_457 - link to the publication
  5. Species-specific paternal age effects and sperm methylation levels of developmentally important genes
    Authors:
    Andreas Prell, Mustafa Orkun Sen, Ramya Potabattula, Laura Bernhardt, Marcus Dittrich, Thomas Hahn, Martin Schorsch, Federica Zacchini, Grazyna Ewa Ptak, Heiner Niemann, Thomas Haaf
    Academic press:
    Cells (rok: 2022, tom: 11(4):731, strony: ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11040731 - link to the publication
  6. Ribosomal DNA methylation in human and mouse oocytes increases with age
    Authors:
    Ramya Potabattula, Tom Trapphoff, Marcus Dittrich, Kinga Fic, Grazyna E Ptak, Stefan Dieterle, Thomas Haaf
    Academic press:
    Aging (rok: 2022, tom: 14, strony: 1214—1232), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/aging.203891 - link to the publication
  7. Species-specific paternal age effects and sperm methylation levels of developmentally important genes
    Authors:
    Andreas Prell, Mustafa Orkun Sen, Ramya Potabattula, Laura Bernhardt, Marcus Dittrich, Thomas Hahn, Martin Schorsch, Federica Zacchini, Grazyna Ewa Ptak, Heiner Niemann, Thomas Haaf
    Academic press:
    Cells (rok: 2022, tom: 11(4):731, strony: ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11040731 - link to the publication
  8. The effects of assisted reproduction technologies on metabolic health and disease
    Authors:
    Maria Florencia Heber, Grażyna Ewa Ptak
    Academic press:
    Biology of Reproduction (rok: 2020, tom: 104(4), strony: 734–744), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/biolre/ioaa224 - link to the publication
  9. The effects of assisted reproduction technologies on metabolic health and disease
    Authors:
    Maria Florencia Heber, Grażyna Ewa Ptak
    Academic press:
    Biology of Reproduction (rok: 2020, tom: 104(4), strony: 734–744), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/biolre/ioaa224 - link to the publication
  10. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies
    Authors:
    Richard Musson, Łukasz Gąsior, Simona Bisogno, Grażyna Ewa Ptak
    Academic press:
    Human Reproduction Update (rok: 2022, tom: 28, strony: 376–399), Wydawca: Oxford Academics
    Status:
    Published
    DOI:
    10.1093/humupd/dmab046 - link to the publication
  11. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies
    Authors:
    Richard Musson, Łukasz Gąsior, Simona Bisogno, Grażyna Ewa Ptak
    Academic press:
    Human Reproduction Update (rok: 2022, tom: dmab046, strony: ), Wydawca: Oxford Academics
    Status:
    Published
    DOI:
    10.1093/humupd/dmab046 - link to the publication
  12. Lipid droplets in mammalian eggs are utilized during embryonic diapause
    Authors:
    Roberta Arena, Simona Bisogno, Łukasz Gąsior, Joanna Rudnicka, Laura Bernhardt, Thomas Haaf, Federica Zacchini, Michał Bochenek, Kinga Fic, Ewelina Bik, Małgorzata Barańska, Anna Bodzoń-Kułakowska, Piotr Suder, Joanna Depciuch, Artur Gurgul, Zbigniew Polański, Grażyna E. Ptak
    Academic press:
    PNAS (rok: 2021, tom: 118(10), strony: ), Wydawca: National Academy of Sciences of the United States of America
    Status:
    Published
    DOI:
    10.1073/pnas.2018362118 - link to the publication
  13. Ribosomal DNA methylation in human and mouse oocytes increases with age.
    Authors:
    Potabattula R, Trapphoff T, Dittrich M, Fic K, Ptak GE, Dieterle S, Haaf T.
    Academic press:
    Aging (rok: 2022, tom: 14(3), strony: 1214—1232), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/aging.203891 - link to the publication
  14. Lipid droplets in mammalian eggs are utilized during embryonic diapause
    Authors:
    Roberta Arena, Simona Bisogno, Łukasz Gąsior, Joanna Rudnicka, Laura Bernhardt, Thomas Haaf, Federica Zacchini, Michał Bochenek, Kinga Fic, Ewelina Bik, Małgorzata Barańska, Anna Bodzoń-Kułakowska, Piotr Suder, Joanna Depciuch, Artur Gurgul, Zbigniew Polański, Grażyna E. Ptak
    Academic press:
    PNAS (rok: 2021, tom: 118(10), strony: ), Wydawca: National Academy of Sciences of the United States of America
    Status:
    Published
    DOI:
    10.1073/pnas.2018362118 - link to the publication
  15. Późne rodzicielstwo i rozród wspomagany: analiza ryzyka wystąpienia chorób przewlekłych u potomstwa
    Authors:
    Maria Florencia Heber, Hafsa Gulzar, Richard Musson, Simona Bisogno, Kinga Fic, Grażyna Ewa Ptak
    Academic press:
    Postępy biochemii (rok: 2022, tom: Tom 68 nr 3, strony: 321-335), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_457 - link to the publication
  16. Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
    Authors:
    Federica Zacchini, Maria Florencia Heber, Roberta Arena, Natalia Radczuk, Urszula Jankowska, Grażyna Ewa Ptak
    Academic press:
    Theriogenology (rok: 2021, tom: 171, strony: 119-129), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2021.05.022 - link to the publication
  17. Ribosomal DNA methylation in human and mouse oocytes increases with age.
    Authors:
    Potabattula R, Trapphoff T, Dittrich M, Fic K, Ptak GE, Dieterle S, Haaf T.
    Academic press:
    Aging (rok: 2022, tom: 14(3), strony: 1214—1232), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/aging.203891 - link to the publication
  18. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies
    Authors:
    Richard Musson, Łukasz Gąsior, Simona Bisogno, Grażyna Ewa Ptak
    Academic press:
    Human Reproduction Update (rok: 2022, tom: dmab046, strony: ), Wydawca: Oxford Academics
    Status:
    Published
    DOI:
    10.1093/humupd/dmab046 - link to the publication
  19. The effects of assisted reproduction technologies on metabolic health and disease
    Authors:
    Maria Florencia Heber, Grażyna Ewa Ptak
    Academic press:
    Biology of Reproduction (rok: 2020, tom: 104(4), strony: 734–744), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/biolre/ioaa224 - link to the publication
  20. Species-specific paternal age effects and sperm methylation levels of developmentally important genes
    Authors:
    Andreas Prell, Mustafa Orkun Sen, Ramya Potabattula, Laura Bernhardt, Marcus Dittrich, Thomas Hahn, Martin Schorsch, Federica Zacchini, Grazyna Ewa Ptak, Heiner Niemann, Thomas Haaf
    Academic press:
    Cells (rok: 2022, tom: 11(4):731, strony: ), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11040731 - link to the publication
  21. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies
    Authors:
    Richard Musson, Łukasz Gąsior, Simona Bisogno, Grażyna Ewa Ptak
    Academic press:
    Human Reproduction Update (rok: 2022, tom: dmab046, strony: ), Wydawca: Oxford Academics
    Status:
    Published
    DOI:
    10.1093/humupd/dmab046 - link to the publication
  22. Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
    Authors:
    Federica Zacchini, Maria Florencia Heber, Roberta Arena, Natalia Radczuk, Urszula Jankowska, Grażyna Ewa Ptak
    Academic press:
    Theriogenology (rok: 2021, tom: 171, strony: 119-129), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2021.05.022 - link to the publication
  1. Nile Red and BODIPY Staining of Lipid Droplets in Mouse Oocytes and Embryos.
    Authors:
    Bisogno S, Gąsior Ł, Ptak GE.
    Book:
    Methods Mol Biol. (rok: 2023, tom: 2566, strony: 205-212), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/978-1-0716-2675-7_16 - link to the publication

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