Projects funded by the NCN
Exploring the sequence-structure relationship as a starting point for the design of DNA G-quadruplexes with a given topology -- an integrative approach combining molecular simulations with experimental methods
2019/35/B/ST4/03559
Keywords:
DNA G-quadruplex conformational equilibrium molecular dynamics NMR spectroscopy
Descriptors:
- ST4_004:
- ST4_002:
- ST4_003:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Politechnika Gdańska
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 11
Call: OPUS 18 - announced on 2019-09-16
Amount awarded: 1 788 600 PLN
Project start date (Y-m-d): 2020-06-19
Project end date (Y-m-d): 2026-06-18
Project duration:: 72 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations.Authors:K.A. Hossain, M. Jurkowski, J. Czub, M. KogutAcademic press:Comput. Struct. Biotechnol. J. (rok: 2021, tom: 19, strony: 2526-2536), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.csbj.2021.04.039 - link to the publication
- Why Are Left-Handed G-Quadruplexes Scarce?Authors:M. Jurkowski, M. Kogut, S. Sappati, J. CzubAcademic press:Journal of Physical Chemistry Letters (rok: 2024, tom: 15, strony: 3142-3148), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.jpclett.3c0358 - link to the publication