Exploring the sequence-structure relationship as a starting point for the design of DNA G-quadruplexes with a given topology -- an integrative approach combining molecular simulations with experimental methods
2019/35/B/ST4/03559
Keywords
Descriptors
- ST4_004: Chemia teoretyczna i obliczeniowa
- ST4_002: Metody spektroskopowe i spektrometryczne
- ST4_003: Struktura i architektura molekularna
Panel
ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution
Politechnika Gdańska
Voivodeship: pomorskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 11
Call
OPUS 18 – announced on 2019-09-16
- Amount awarded
- 1 788 600 PLN
- Project start date
- 2020-06-19
- Project end date
- 2026-06-18
- Project duration
- 72 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations.
- Authors:
- K.A. Hossain, M. Jurkowski, J. Czub, M. Kogut
- Academic press:
- Comput. Struct. Biotechnol. J. (year: 2021, volume: 19, pages: 2526-2536), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.csbj.2021.04.039 – link to the publication
-
Large-scale conformational analysis explains G-quadruplex topological landscape
- Authors:
- M. Jurkowski, M. Kogut, M. Olewniczak, J. Glinko, J. Czub
- Academic press:
- J. Phys. Chem. B (year: 2025, volume: 129, pages: 9622–9632), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.jpcb.5c04372 – link to the publication
-
Why Are Left-Handed G-Quadruplexes Scarce?
- Authors:
- M. Jurkowski, M. Kogut, S. Sappati, J. Czub
- Academic press:
- Journal of Physical Chemistry Letters (year: 2024, volume: 15, pages: 3142-3148), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.jpclett.3c0358 – link to the publication