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The role of the mitochondrial potassium channels in damage caused by urban particulate matters (PM) - search for a new cytoprotection strategy.

2019/35/B/NZ1/02546

Keywords

Descriptors

  • NZ1_003: Biofizyka
  • NZ1_002: Biochemia
  • NZ1_001: Biologia molekularna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Piotr Bednarczyk

Number of co-investigators in the project: 7

Call

OPUS 18 – announced on 2019-09-16

Amount awarded
2 378 400 PLN
Project start date
2020-07-27
Project end date
2026-01-26
Project duration
66 months (the same as in the proposal)
Project status
Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (11)

  1. Effect of Quercetin on mitoBKCa Channel and Mitochondrial Function in Human Bronchial Epithelial Cells Exposed to Particulate Matter

    Authors:
    Adrianna Dabrowska, Miroslaw Zajac, Piotr Bednarczyk, Agnieszka Lukasiak
    Academic press:
    Int. J. Mol. Sci. (year: 2022, volume: 24, pages: 638), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24010638 – link to the publication

  2. Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium

    Authors:
    M Zajac, A Lepissier, E Dréano, B Chevalier, A Hatton, M Kelly-Aubert, D Guidone, G Planelles, A Edelman, E Girodon, A Hinzpeter, G Crambert, I Pranke, L J V Galietta, I Sermet-Gaudelus
    Academic press:
    Front Pharmacol (year: 2023, volume: 14, pages: 1293578), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2023.1293578 – link to the publication

  3. Modulation of the Respiratory Epithelium Physiology by Flavonoids—Insights from 16HBEo cell Model

    Authors:
    Jakub Hoser, GabrielaWeglinska, Aleksandra Samsel, Kamila Maliszewska-Olejniczak, Piotr Bednarczyk and Miroslaw Zajac
    Academic press:
    International Journal of Molecular Sciences (year: 2024, volume: 25, pages: 11999), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252211999 – link to the publication

  4. Changes in Ion Transport across Biological Membranes Exposed to Particulate Matter

    Authors:
    Jakub Hoser, Adrianna Dabrowska, Miroslaw Zajac, Piotr Bednarczyk
    Academic press:
    Membranes (Basel) (year: 2023, volume: 13, pages: 763), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes13090763 – link to the publication

  5. Novel insights into the role of ion channels in cellular DNA damage response

    Authors:
    Kamila Maliszewska-Olejniczak, Piotr Bednarczyk
    Academic press:
    Mutat Res Rev Mutat Res (year: 2024, volume: 793, pages: 108488), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrrev.2024.108488 – link to the publication

  6. Deficiency of the BKCa potassium channel displayed significant implications for the physiology of the human bronchial epithelium

    Authors:
    Kamila Maliszewska-Olejniczak, Karolina Pytlak, Adrianna Dabrowska, Monika Zochowska, Jakub Hoser, Agnieszka Lukasiak, Miroslaw Zajac, Bogusz Kulawiak, Piotr Bednarczyk
    Academic press:
    Mitochondrion (year: 2024, volume: 76, pages: 101880), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2024.101880 – link to the publication

  7. Mitochondrial potassium channels: New properties and functions

    Authors:
    Adam Szewczyk, Piotr Bednarczyk, Bogusz Kulawiak, Monika Żochowska, Barbara Kalenik, Joanna Lewandowska, Karolina Pytlak, Shur Gałecka, Antoni Wrzosek, Piotr Koprowski
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Bioenergetics (year: 2025, volume: 1866, pages: 149546), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2025.149546 – link to the publication

  8. The Distribution and Role of the CFTR Protein in the Intracellular Compartments

    Authors:
    Agnieszka Lukasiak and Miroslaw Zajac
    Academic press:
    Membranes (year: 2021, volume: 11, pages: 804), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11110804 – link to the publication

  9. Application of Machine-Learning Methods to Recognize mitoBK Channels from Different Cell Types Based on the Experimental Patch-Clamp Results

    Authors:
    Monika Richter-Laskowska, Paulina Trybek, Piotr Bednarczyk, Agata Wawrzkiewicz-Jałowiecka
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 840), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020840 – link to the publication

  10. Dynamical diversity of mitochondrial BK channels located in different cell types

    Authors:
    Agata Wawrzkiewicz-Jałowiecka, Paulina Trybek, Łukasz Machura, Piotr Bednarczyk
    Academic press:
    BioSystems (year: 2021, volume: 199, pages: 104310), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biosystems.2020.104310 – link to the publication

  11. Identification of the Large‐Conductance Ca2+‐Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells

    Authors:
    Aleksandra Sek, Rafal P Kampa, Bogusz Kulawiak, Adam Szewczyk, Piotr Bednarczyk
    Academic press:
    Molecules (year: 2021, volume: 26, pages: 3233), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113233 – link to the publication

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