Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of the mitochondrial potassium channels in damage caused by urban particulate matters (PM) - search for a new cytoprotection strategy.

2019/35/B/NZ1/02546

Keywords:

mitochondria potassium channels urban particulate matters cytoprotection

Descriptors:

  • NZ1_003:
  • NZ1_002:
  • NZ1_001:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Bednarczyk 

Number of co-investigators in the project: 7

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 378 400 PLN

Project start date (Y-m-d): 2020-07-27

Project end date (Y-m-d): 2025-07-26

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (13)
  1. Modulation of the Respiratory Epithelium Physiology by Flavonoids—Insights from 16HBEo cell Model
    Authors:
    Jakub Hoser, GabrielaWeglinska, Aleksandra Samsel, Kamila Maliszewska-Olejniczak, Piotr Bednarczyk and Miroslaw Zajac
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 11999), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252211999 - link to the publication
  2. Deficiency of the BKCa potassium channel displayed significant implications for the physiology of the human bronchial epithelium
    Authors:
    Kamila Maliszewska-Olejniczak, Karolina Pytlak, Adrianna Dabrowska, Monika Zochowska, Jakub Hoser, Agnieszka Lukasiak, Miroslaw Zajac, Bogusz Kulawiak, Piotr Bednarczyk
    Academic press:
    Mitochondrion (rok: 2024, tom: 76, strony: 101880), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2024.101880 - link to the publication
  3. The Distribution and Role of the CFTR Protein in the Intracellular Compartments
    Authors:
    Agnieszka Lukasiak and Miroslaw Zajac
    Academic press:
    Membranes (rok: 2021, tom: 11, strony: 804), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11110804 - link to the publication
  4. Changes in Ion Transport across Biological Membranes Exposed to Particulate Matter
    Authors:
    Jakub Hoser, Adrianna Dabrowska, Miroslaw Zajac, Piotr Bednarczyk
    Academic press:
    Membranes (Basel) (rok: 2023, tom: 13, strony: 763), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes13090763 - link to the publication
  5. Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
    Authors:
    M Zajac, A Lepissier, E Dréano, B Chevalier, A Hatton, M Kelly-Aubert, D Guidone, G Planelles, A Edelman, E Girodon, A Hinzpeter, G Crambert, I Pranke, L J V Galietta, I Sermet-Gaudelus
    Academic press:
    Front Pharmacol (rok: 2023, tom: 14, strony: 1293578), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2023.1293578 - link to the publication
  6. Application of Machine-Learning Methods to Recognize mitoBK Channels from Different Cell Types Based on the Experimental Patch-Clamp Results
    Authors:
    Monika Richter-Laskowska, Paulina Trybek, Piotr Bednarczyk, Agata Wawrzkiewicz-Jałowiecka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 840), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020840 - link to the publication
  7. Novel insights into the role of ion channels in cellular DNA damage response
    Authors:
    Kamila Maliszewska-Olejniczak, Piotr Bednarczyk
    Academic press:
    Mutat Res Rev Mutat Res (rok: 2024, tom: 793, strony: 108488), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrrev.2024.108488 - link to the publication
  8. Mitochondrial potassium channels: New properties and functions
    Authors:
    Adam Szewczyk, Piotr Bednarczyk, Bogusz Kulawiak, Monika Żochowska, Barbara Kalenik, Joanna Lewandowska, Karolina Pytlak, Shur Gałecka, Antoni Wrzosek, Piotr Koprowski
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Bioenergetics (rok: 2025, tom: 1866, strony: 149546), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2025.149546 - link to the publication
  9. Effect of Quercetin on mitoBKCa Channel and Mitochondrial Function in Human Bronchial Epithelial Cells Exposed to Particulate Matter
    Authors:
    Adrianna Dabrowska, Miroslaw Zajac, Piotr Bednarczyk, Agnieszka Lukasiak
    Academic press:
    Int. J. Mol. Sci. (rok: 2022, tom: 24, strony: 638), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24010638 - link to the publication
  10. Dynamical diversity of mitochondrial BK channels located in different cell types
    Authors:
    Agata Wawrzkiewicz-Jałowiecka, Paulina Trybek, Łukasz Machura, Piotr Bednarczyk
    Academic press:
    BioSystems (rok: 2021, tom: 199, strony: 104310), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biosystems.2020.104310 - link to the publication
  11. Identification of the Large‐Conductance Ca2+‐Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells
    Authors:
    Aleksandra Sek, Rafal P Kampa, Bogusz Kulawiak, Adam Szewczyk, Piotr Bednarczyk
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 3233), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113233 - link to the publication
  12. Deficiency of the BKCa potassium channel displayed significant implications for the physiology of the human bronchial epithelium
    Authors:
    Kamila Maliszewska-Olejniczak, Karolina Pytlak, Adrianna Dabrowska, Monika Zochowska, Jakub Hoser, Agnieszka Lukasiak, Miroslaw Zajac, Bogusz Kulawiak, Piotr Bednarczyk
    Academic press:
    Mitochondrion (rok: 2024, tom: 76, strony: 101880), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2024.101880 - link to the publication
  13. The Distribution and Role of the CFTR Protein in the Intracellular Compartments
    Authors:
    Agnieszka Lukasiak and Miroslaw Zajac
    Academic press:
    Molecules (rok: 2021, tom: 11, strony: 804), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11110804 - link to the publication

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