Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular and cellular mechanisms of pro-regenerative activity of stem cell- derived extracellular vesicles (EVs) in ischemic myocardial injuries: Role of microRNAs.

2019/34/A/NZ3/00134

Keywords:

extracellular vesicles (EVs) microRNA myocardial ischemia tissue regeneration paracrine effects induced pluripotent stem cells (iPSCs) mesenchymal stem/ stromal cells (MSCs)

Descriptors:

  • NZ3_008:
  • NZ1_001:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Katarzyna Zuba-Surma 

Number of co-investigators in the project: 7

Call: MAESTRO 11 - announced on 2019-06-17

Amount awarded: 4 494 000 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2026-09-30

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Induced pluripotent stem cell-derived extracellular vesicles enriched with miR-126 induce proangiogenic properties and promote repair of ischemic tissue.
    Authors:
    Kmiotek-Wasylewska K, Łabędź-Masłowska A, Bobis-Wozowicz S, Karnas E, Noga S, Sekuła-Stryjewska M, Woźnicka O, Madeja Z, Dawn B, Zuba-Surma EK
    Academic press:
    FASEB Journal (rok: 2024, tom: 38(2), strony: e23415), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202301836R - link to the publication
  2. Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.
    Authors:
    Łabędź-Masłowska A, Vergori L, Kędracka-Krok S, Karnas E, Bobis-Wozowicz S, Sekuła-Stryjewska M, Sarna M, Andriantsitohaina R, Zuba-Surma EK.
    Academic press:
    Journal of Nanobiotechnology (rok: 2024, tom: 22(1), strony: 60), Wydawca: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12951-024-02304-y - link to the publication
  3. Anti‑inflammatory, Anti‑fibrotic and Pro‑cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR‑1 and miR‑199a on Human Cardiac Fibroblasts
    Authors:
    Katarzyna Kmiotek‑Wasylewska, Sylwia Bobis‑Wozowicz, Elżbieta Karnas, Monika Orpel, Olga Woźnicka, Zbigniew Madeja, Buddhadeb Dawn, Ewa K. Zuba‑Surma
    Academic press:
    Stem Cell Reviews and Reports (rok: 2023, tom: 19(8), strony: 2756-2773), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10621-2 - link to the publication
  4. Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives.
    Authors:
    Elz˙ bieta Karnas, Patrycja Dudek, Ewa K. Zuba-Surma
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 1120175), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1120175 - link to the publication
  5. Evaluation of the Safety and Regenerative Potential of Human Mesenchymal Stem Cells and Their Extracellular Vesicles in a Transgenic Pig Model of Cartilage-Bone Injury In Vivo – Preclinical Study
    Authors:
    A. Łabędź-Masłowska, J. Wieczorek, M. Mierzwiński, M. Sekuła-Stryjewska, S. Noga, J. Rajca, P. Duda, K. Milian-Ciesielska, E. Karnas, K. Kmiotek-Caller, A. Szkaradek, Zbigniew Madeja, K. Ficek, J. Jura, E. Zuba-Surma
    Academic press:
    Stem Cell Reviews and Reports (rok: 2025, tom: 21, strony: 1075–1095), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10853-4 - link to the publication
  1. Impact of genetic modification of microRNA cargo in human induced pluripotent stem cell-derived extracellular vesicles on their pro-regenerative activity in ischemic tissues
    Authors:
    E. Karnas, P. Cierniak, S. Noga, G. Cheng, D. Ali, A. Labedz-Maslowska, M. Girgis, B. Dawn, E. Zuba-Surma
    Conference:
    ISEV2025 Abstract Book (rok: 2025, tom: ISEV2025 Annual Meeting, strony: 290), Wydawca: Wiley
    Data:
    konferencja 24-27.04.2025
    Status:
    Published
    DOI:
    10.1002/jev2.70157 - link to the publication
  2. Polyelectrolytes are effective cryoprotectants for extracellular vesicles
    Authors:
    E. Karnas, M.Zając, K. Kmiotek-Caller, K. Kamiński, S.-I. Yusa, S. Kędracka-Krok, P. Dudek, K. Szczubiałka, M. Nowakowska, E.K. Zuba-Surma
    Conference:
    ISEV2025 Abstract Book (rok: 2025, tom: ISEV2025 Annual Meeting, strony: 551-552), Wydawca: Wiley
    Data:
    konferencja 24-27.04.2025
    Status:
    Published
    DOI:
    10.1002/jev2.70157 - link to the publication

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