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Molecular and cellular mechanisms of pro-regenerative activity of stem cell- derived extracellular vesicles (EVs) in ischemic myocardial injuries: Role of microRNAs.

2019/34/A/NZ3/00134

Keywords

Descriptors

  • NZ3_008: Komórki macierzyste
  • NZ1_001: Biologia molekularna

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Ewa Katarzyna Zuba-Surma

Number of co-investigators in the project: 7

Call

MAESTRO 11 – announced on 2019-06-17

Amount awarded
4 494 000 PLN
Project start date
2020-10-01
Project end date
2026-09-30
Project duration
72 months (the same as in the proposal)
Project status
Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (5)

  1. Induced pluripotent stem cell-derived extracellular vesicles enriched with miR-126 induce proangiogenic properties and promote repair of ischemic tissue.

    Authors:
    Kmiotek-Wasylewska K, Łabędź-Masłowska A, Bobis-Wozowicz S, Karnas E, Noga S, Sekuła-Stryjewska M, Woźnicka O, Madeja Z, Dawn B, Zuba-Surma EK
    Academic press:
    FASEB Journal (year: 2024, volume: 38(2), pages: e23415), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202301836R – link to the publication

  2. Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.

    Authors:
    Łabędź-Masłowska A, Vergori L, Kędracka-Krok S, Karnas E, Bobis-Wozowicz S, Sekuła-Stryjewska M, Sarna M, Andriantsitohaina R, Zuba-Surma EK.
    Academic press:
    Journal of Nanobiotechnology (year: 2024, volume: 22(1), pages: 60), Publisher: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12951-024-02304-y – link to the publication

  3. Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives.

    Authors:
    Elz˙ bieta Karnas, Patrycja Dudek, Ewa K. Zuba-Surma
    Academic press:
    Frontiers in Immunology (year: 2023, volume: 14, pages: 1120175), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1120175 – link to the publication

  4. Evaluation of the Safety and Regenerative Potential of Human Mesenchymal Stem Cells and Their Extracellular Vesicles in a Transgenic Pig Model of Cartilage-Bone Injury In Vivo – Preclinical Study

    Authors:
    A. Łabędź-Masłowska, J. Wieczorek, M. Mierzwiński, M. Sekuła-Stryjewska, S. Noga, J. Rajca, P. Duda, K. Milian-Ciesielska, E. Karnas, K. Kmiotek-Caller, A. Szkaradek, Zbigniew Madeja, K. Ficek, J. Jura, E. Zuba-Surma
    Academic press:
    Stem Cell Reviews and Reports (year: 2025, volume: 21, pages: 1075–1095), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10853-4 – link to the publication

  5. Anti‑inflammatory, Anti‑fibrotic and Pro‑cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR‑1 and miR‑199a on Human Cardiac Fibroblasts

    Authors:
    Katarzyna Kmiotek‑Wasylewska, Sylwia Bobis‑Wozowicz, Elżbieta Karnas, Monika Orpel, Olga Woźnicka, Zbigniew Madeja, Buddhadeb Dawn, Ewa K. Zuba‑Surma
    Academic press:
    Stem Cell Reviews and Reports (year: 2023, volume: 19(8), pages: 2756-2773), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10621-2 – link to the publication

Articles in post-conference publications (2)

  1. Impact of genetic modification of microRNA cargo in human induced pluripotent stem cell-derived extracellular vesicles on their pro-regenerative activity in ischemic tissues

    Authors:
    E. Karnas, P. Cierniak, S. Noga, G. Cheng, D. Ali, A. Labedz-Maslowska, M. Girgis, B. Dawn, E. Zuba-Surma
    Conference:
    ISEV2025 Abstract Book (year: 2025, volume: ISEV2025 Annual Meeting, pages: 290), Publisher: Wiley
    Date:
    conference 24-27.04.2025
    Status:
    Published
    DOI:
    10.1002/jev2.70157 – link to the publication

  2. Polyelectrolytes are effective cryoprotectants for extracellular vesicles

    Authors:
    E. Karnas, M.Zając, K. Kmiotek-Caller, K. Kamiński, S.-I. Yusa, S. Kędracka-Krok, P. Dudek, K. Szczubiałka, M. Nowakowska, E.K. Zuba-Surma
    Conference:
    ISEV2025 Abstract Book (year: 2025, volume: ISEV2025 Annual Meeting, pages: 551-552), Publisher: Wiley
    Date:
    conference 24-27.04.2025
    Status:
    Published
    DOI:
    10.1002/jev2.70157 – link to the publication

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