Projects funded by the NCN
Molecular and cellular mechanisms of pro-regenerative activity of stem cell- derived extracellular vesicles (EVs) in ischemic myocardial injuries: Role of microRNAs.
2019/34/A/NZ3/00134
Keywords:
extracellular vesicles (EVs) microRNA myocardial ischemia tissue regeneration paracrine effects induced pluripotent stem cells (iPSCs) mesenchymal stem/ stromal cells (MSCs)
Descriptors:
- NZ3_008:
- NZ1_001:
Panel:
NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution :
Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego
woj. małopolskie
Principal investigator (from the host institution):
prof. Ewa Katarzyna Zuba-Surma
Number of co-investigators in the project: 7
Call: MAESTRO 11 - announced on 2019-06-17
Amount awarded: 4 494 000 PLN
Project start date (Y-m-d): 2020-10-01
Project end date (Y-m-d): 2025-09-30
Project duration:: 60 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (5)
- Anti‑inflammatory, Anti‑fibrotic and Pro‑cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR‑1 and miR‑199a on Human Cardiac FibroblastsAuthors:Katarzyna Kmiotek‑Wasylewska, Sylwia Bobis‑Wozowicz, Elżbieta Karnas, Monika Orpel, Olga Woźnicka, Zbigniew Madeja, Buddhadeb Dawn, Ewa K. Zuba‑SurmaAcademic press:Stem Cell Reviews and Reports (rok: 2023, tom: 19(8), strony: 2756-2773), Wydawca: Springer NatureStatus:PublishedDOI:10.1007/s12015-023-10621-2 - link to the publication
- Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives.Authors:Elz˙ bieta Karnas, Patrycja Dudek, Ewa K. Zuba-SurmaAcademic press:Frontiers in Immunology (rok: 2023, tom: 14, strony: 1120175), Wydawca: FrontiersStatus:PublishedDOI:10.3389/fimmu.2023.1120175 - link to the publication
- Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.Authors:Łabędź-Masłowska A, Vergori L, Kędracka-Krok S, Karnas E, Bobis-Wozowicz S, Sekuła-Stryjewska M, Sarna M, Andriantsitohaina R, Zuba-Surma EK.Academic press:Journal of Nanobiotechnology (rok: 2024, tom: 22(1), strony: 60), Wydawca: BMC Springer NatureStatus:PublishedDOI:10.1186/s12951-024-02304-y - link to the publication
- Induced pluripotent stem cell-derived extracellular vesicles enriched with miR-126 induce proangiogenic properties and promote repair of ischemic tissue.Authors:Kmiotek-Wasylewska K, Łabędź-Masłowska A, Bobis-Wozowicz S, Karnas E, Noga S, Sekuła-Stryjewska M, Woźnicka O, Madeja Z, Dawn B, Zuba-Surma EKAcademic press:FEBS Journal (rok: 2024, tom: 38(2), strony: e23415), Wydawca: WileyStatus:PublishedDOI:10.1096/fj.202301836R - link to the publication
- Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.Authors:Łabędź-Masłowska A, Vergori L, Kędracka-Krok S, Karnas E, Bobis-Wozowicz S, Sekuła-Stryjewska M, Sarna M, Andriantsitohaina R, Zuba-Surma EK.Academic press:Journal of Nanobiotechnology (rok: 2024, tom: 22(1), strony: 60), Wydawca: BMC Springer NatureStatus:PublishedDOI:10.1186/s12951-024-02304-y - link to the publication