Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Biomechanical heterogeneity of cancer cells as a parameter for high throughput detectability

2019/34/H/ST3/00526

Keywords:

mechanical and rheological properties of cells cancer heterogenuity microfluidics atomic force microscopy high throughput detection

Descriptors:

  • ST3_016:
  • ST5_009:
  • NZ1_003:

Panel:

ST3 - Condensed matter physics: structure, electronic properties, fluids, nanosciences, biological physics

Host institution :

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Barbara Lekka 

Number of co-investigators in the project: 9

Call: GRIEG 1 - announced on 2019-06-17

Amount awarded: 4 241 869 PLN

Project start date (Y-m-d): 2020-09-18

Project end date (Y-m-d): 2024-03-31

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (13)
  1. Migration, proliferation, and elasticity of bladder cancer cells on lectin-coated surfaces
    Authors:
    M.Luty, R.Szydlak, J.Pabijan, I.H.Øvreeide, V.E.Prot, J.Zemla, B.T.Stokke, M.Lekka
    Academic press:
    Cancers , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    link to the publication
  2. Entanglement of vimentin shapes the microrheological response of suspended-like cells to oscillatory strains induced by different AFM probe geometries
    Authors:
    Joanna Zemła, Marcin Luty, Joanna Pabijan, Renata Szydlak, Ingrid H. Øvreeide, Victorien E. Prot, Florian Kumpfe, Bjørn T. Stokke, Małgorzata Lekka
    Academic press:
    New Journal of Physics (rok: 2024, ), Wydawca: IOP
    Status:
    Submitted
  3. Tubulin-Targeted Therapy in Melanoma Increases Cell Invasive Potential by Activation of Actomyosin Cytoskeleton – an in vitro study
    Authors:
    M.Luty, R.Szydlak, J.Pabijan, J.Zemla, I.H.Oevreeide, V.E.Prot, B.T.Stokke, M.Lekka, B.Zapotoczny
    Academic press:
    Drug Resistance Updates (rok: 2024, ), Wydawca: Elsevier
    Status:
    Submitted
  4. Plasma Treatment of PDMS for Microcontact Printing (μCP) of Lectins Decreases Silicone Transfer and Increases the Adhesion of Bladder Cancer Cells
    Authors:
    Joanna Zemla, Renata Szydlak, Katarzyna Gajos, Łukasz Kozłowski, Tomasz Zieliński, Marcin Luty, Ingrid H. Øvreeide, Victorien E. Prot, Bjørn T. Stokke, Małgorzata Lekka
    Academic press:
    ACS Applied Materials & Interfaces (rok: 2023, tom: 15, strony: 51863-51875), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsami.3c09195 - link to the publication
  5. Nanomechanics in Monitoring the Effectiveness of Drugs Targeting the Cancer Cell Cytoskeleton
    Authors:
    A.Kubiak, T.Zielinski, J.Pabijan, M.Lekka
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 8786), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ijms21228786 - link to the publication
  6. Nanomechanics in Monitoring the Effectiveness of Drugs Targeting the Cancer Cell Cytoskeleton
    Authors:
    A.Kubiak, T.Zielinski, J.Pabijan, M.Lekka
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 8786), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ijms21228786 - link to the publication
  7. Detecting normal and cancer skin cells via glycosylation and adhesion signatures: A path to enhanced microfluidic phenotyping
    Authors:
    R.Szydlak, M.Luty, V.E.Prot, I.H.Øvreeide, J.Zemła, B.T.Stokke, M.Lekka
    Academic press:
    Biosensors and Bioelectronics (rok: 2024, tom: 258, strony: 116337), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2024.116337 - link to the publication
  8. On the Determination of Mechanical Properties of Aqueous Microgels-Towards High-Throughput Characterization
    Authors:
    I.H.Oevreeide, R.Szydlak, M.Luty, H.Ahmed, V.Prot, B.H.Skallerud, J.Zemła , M.Lekka, B.T.Stokke.
    Academic press:
    Gels (rok: 2021, tom: 7, strony: 64), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/gels7020064 - link to the publication
  9. Bladder cancer cells interaction with lectin-coated surfaces under static and flow conditions
    Authors:
    Renata Szydlak, Marcin Luty, Ingrid H. Øvreeide, Tomasz Zieliński, Victorien E. Prot, Joanna Zemła, Bjørn T. Stokke, Małgorzata Lekka
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 8213), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ijms24098213 - link to the publication
  10. Bladder cancer cells interaction with lectin-coated surfaces under static and flow conditions
    Authors:
    Renata Szydlak, Marcin Luty, Ingrid H. Øvreeide, Tomasz Zieliński, Victorien E. Prot, Joanna Zemła, Bjørn T. Stokke, Małgorzata Lekka
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: brak, strony: brak), Wydawca: MPDI
    Status:
    Submitted
  11. Nanomechanics in Monitoring the Effectiveness of Drugs Targeting the Cancer Cell Cytoskeleton
    Authors:
    A.Kubiak, T.Zielinski, J.Pabijan, M.Lekka
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 8786), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ijms21228786 - link to the publication
  12. On the Determination of Mechanical Properties of Aqueous Microgels-Towards High-Throughput Characterization
    Authors:
    I.H.Oevreeide, R.Szydlak, M.Luty, H.Ahmed, V.Prot, B.H.Skallerud, J.Zemła , M.Lekka, B.T.Stokke.
    Academic press:
    Gels (rok: 2021, tom: 7, strony: 64), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/gels7020064 - link to the publication
  13. On the Determination of Mechanical Properties of Aqueous Microgels-Towards High-Throughput Characterization
    Authors:
    I.H.Oevreeide, R.Szydlak, M.Luty, H.Ahmed, V.Prot, B.H.Skallerud, J.Zemła , M.Lekka, B.T.Stokke.
    Academic press:
    Gels (rok: 2021, tom: 7, strony: 64), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/gels7020064 - link to the publication

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