Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The supersaturated drug delivery systems (SDDS) as a universal platform to address the problem of poor drugs' solubility

2019/34/E/NZ7/00245

Keywords:

poorly soluble drugs supersaturated solutions amorphous systems solid dispersions nanocrystals mesoporous silica-based systems

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Collegium Medicum

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Maria Krupa 

Number of co-investigators in the project: 10

Call: SONATA BIS 9 - announced on 2019-06-17

Amount awarded: 2 524 020 PLN

Project start date (Y-m-d): 2020-10-30

Project end date (Y-m-d): 2026-10-29

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  • Book publications / chapters in book publications (3)
  1. Data regarding particle size distribution, thermal properties and gaseous phase hydration of co-milled solid dispersions composed of tadalafil and Soluplus
    Authors:
    Karol Kubat, Anna Krupa, Witold Brniak, Agnieszka Węgrzyn, Dorota Majda, Agata Bogdał, Hubert Harańczyk
    Academic press:
    Data in Brief (rok: 2022, tom: 43, strony: 108451), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dib.2022.108451 - link to the publication
  2. Kollidon VA64 and Soluplus as modern polymeric carriers for amorphous solid dispersions
    Authors:
    Dominik Strojewski, Anna Krupa
    Academic press:
    Polimery w Medycynie (rok: 2022, tom: 52, strony: 19-29), Wydawca: Wydawnictwo Uniwersytetu Medycznego we Wrocławiu
    Status:
    Published
    DOI:
    10.17219/pim/150267 - link to the publication
  3. Challenges and Opportunities for Celecoxib Repurposing
    Authors:
    Urszula Bąk; Anna Krupa
    Academic press:
    Pharmaceutical Research (rok: 2023, tom: 40, strony: 2329-2345), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11095-023-03571-4 - link to the publication
  4. How rotational speed of planetary ball mill and polymer load influence the performance and water vapor sorption in solid dispersions composed of tadalafil and Soluplus
    Authors:
    Karol Kubat, Anna Krupa, Witold Brniak, Agnieszka Węgrzyn, Dorota Majda, Agata Bogdał, Hubert Harańczyk
    Academic press:
    Particuology (rok: 2022, tom: 73, strony: 37-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.partic.2022.04.003 - link to the publication
  5. High energy ball milling vs. nano spray drying in the development of supersaturated systems loaded with bosentan
    Authors:
    Anna Krupa; Florence Danède; Dorota Majda; Agnieszka Węgrzyn; Dominik Strojewski; Ita Kondera; Jean-François Willart
    Academic press:
    European Journal of Pharmaceutics and Biopharmaceutics (rok: 2023, tom: 188, strony: 137-146), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2023.05.014 - link to the publication
  6. Bosentan monohydrate and sildenafil base as two companions in enabling formulations
    Authors:
    Dominik Strojewski, Sebastian Lalik, Florence Danède, Natalia Górska, Aleksandra Deptuch, Monika Marzec, Jean-François Willart, Anna Krupa
    Academic press:
    International Journal of Pharmaceutics (rok: 2024, tom: 661, strony: 124312), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2024.124312 - link to the publication
  7. Molecular phenomena related to moisture uptake in amorphous solid dispersion loaded with bosentan monohydrate and copovidone
    Authors:
    Karol Kubat; Dominik Strojewski; Dorota Majda; Daniel Jakubiec; Aleksandra Andrzejowska; Agata Bogdał; Anna Krupa; Hubert Harańczyk
    Academic press:
    Powder Technology (rok: 2023, tom: 430, strony: 119020), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.powtec.2023.119020 - link to the publication
  8. Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles
    Authors:
    Dominik Strojewski, Anna Krupa
    Academic press:
    Polimery w Medycynie (rok: 2022, tom: 52, strony: 101-111), Wydawca: Wydawnictwo Uniwersytetu Medycznego we Wrocławiu
    Status:
    Published
    DOI:
    10.17219/pim/152230 - link to the publication
  9. Challenges and Opportunities for Celecoxib Repurposing
    Authors:
    Urszula Bąk; Anna Krupa
    Academic press:
    Pharmaceutical Research (rok: 2023, tom: 40, strony: 2329-2345), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11095-023-03571-4 - link to the publication
  10. Thinking of bosentan repurposing - A study on dehydration and amorphization
    Authors:
    Anna Krupa, Florence Danede, Agnieszka Węgrzyn, Dorota Majda, Jean-Francois Willart
    Academic press:
    International Journal of Pharmaceutics (rok: 2022, tom: 622, strony: 121846), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2022.121846 - link to the publication
  1. Authors:
    Ita Kondera
    Book:
    Rozwiązania technologiczne w celu modyfikacji niekorzystnych właściwości fizykochemicznych substancji leczniczych (rok: 2021, ), Wydawca: Uniwersytet Jagielloński
    Status:
    Published
  2. Authors:
    Aneta Augustyn
    Book:
    Wpływ nośników hydrofilowych na rozpuszczalność substancji leczniczych z grupy inhibitorów fosfodiesterazy-5 (rok: 2021, ), Wydawca: Uniwersytet Jagielloński
    Status:
    Published
  3. Authors:
    Karolina Krutak
    Book:
    Modyfikacje technologiczne substancji leczniczych w celu poprawy rozpuszczalności (rok: 2021, ), Wydawca: Uniwersytet Jagielloński
    Status:
    Published

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