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Development of a new approach based on microfluidic Lab-on-a-Chip system and pancreatic islets' 3D models to perform high-throughput studies aimed at functional analyses of pancreatic islets under physiological and pathological conditions.

2019/33/N/ST4/02416

Keywords:

Lab-on-a-chip microfluidic systems pancreaic islets insulin secretion diabetes mellitus type 2 three-dimensional cellular model surface plasmon resonance

Descriptors:

  • ST4_007:
  • ST4_009:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Warszawska

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Patrycja Anna Sokołowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 17 - announced on 2019-03-15

Amount awarded: 204 100 PLN

Project start date (Y-m-d): 2020-02-24

Project end date (Y-m-d): 2023-02-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (2)
  1. Why Can Organoids Improve Current Organ-on-Chip Platforms?
    Authors:
    Patrycja Sokolowska, Agnieszka Zuchowska, Zbigniew Brzozka
    Academic press:
    Organoids (rok: 2022, tom: 1, strony: 69–84), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/organoids1010007 - link to the publication
  2. Investigation of the Therapeutic Potential of New Antidiabetic Compounds Using Islet-on-a-Chip Microfluidic Model
    Authors:
    Patrycja Sokolowska, Elzbieta Jastrzebska, Agnieszka Dobrzyn, Zbigniew Brzozka
    Academic press:
    Biosensors (rok: 2022, tom: 12, strony: 302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/bios12050302 - link to the publication
  3. Islet-on-a-chip: Biomimetic micropillar-based microfluidic system for three-dimensional pancreatic islet cell culture
    Authors:
    Patrycja Sokolowska, Kamil Zukowski, Justyna Janikiewicz, Elzbieta Jastrzebska, Agnieszka Dobrzyn, Zbigniew Brzozka
    Academic press:
    Biosensors and Bioelectronics (rok: 2021, tom: 183, strony: 113215), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2021.113215 - link to the publication
  4. Islet-on-a-chip: Biomimetic micropillar-based microfluidic system for three-dimensional pancreatic islet cell culture
    Authors:
    Patrycja Sokolowska, Kamil Zukowski, Justyna Janikiewicz, Elzbieta Jastrzebska, Agnieszka Dobrzyn, Zbigniew Brzozka
    Academic press:
    Biosensors and Bioelectronics (rok: 2021, tom: 183, strony: 113215), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2021.113215 - link to the publication
  5. Combinations of regenerative medicine and Lab-on-a-chip systems: New hope to restoring the proper function of pancreatic islets in diabetes
    Authors:
    Patrycja Sokolowska, Justyna Janikiewicz, Elzbieta Jastrzebska, Zbigniew Brzozka, Agnieszka Dobrzyn
    Academic press:
    Biosensors and Bioelectronics (rok: 2020, tom: 167, strony: 112451), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2020.112451 - link to the publication
  6. Combinations of regenerative medicine and Lab-on-a-chip systems: New hope to restoring the proper function of pancreatic islets in diabetes
    Authors:
    Patrycja Sokolowska, Justyna Janikiewicz, Elzbieta Jastrzebska, Zbigniew Brzozka, Agnieszka Dobrzyn
    Academic press:
    Biosensors and Bioelectronics (rok: 2020, tom: 167, strony: 112451), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2020.112451 - link to the publication
  7. Investigation of the Therapeutic Potential of New Antidiabetic Compounds Using Islet-on-a-Chip Microfluidic Model
    Authors:
    Patrycja Sokolowska, Elzbieta Jastrzebska, Agnieszka Dobrzyn, Zbigniew Brzozka
    Academic press:
    Biosensors (rok: 2022, tom: 12, strony: 302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/bios12050302 - link to the publication
  1. Micropillar-based microfluidic system for studies of 3D pancreatic islet structures
    Authors:
    Patrycja Sokolowska, Anna Grabowska, Kamil Zukowski, Justyna Janikiewicz, Elzbieta Jastrzebska, Zbigniew Brzozka, Agnieszka Dobrzyn
    Conference:
    24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2020) (rok: 2020, tom: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020), strony: 987 - 988), Wydawca: Chemical and Biological Microsystems Society (CBMS)
    Data:
    konferencja 4-9.10.2020
    Status:
    Published
  2. 5-Hexadecanoyloxyoctadecanoic Acid (5-PAHSA) as a Potential Therapeutic Agent in Diabetes? Preliminary Studies Using the Newly Developed, Fully Functional Islet-on-a-Chip Model
    Authors:
    Patrycja Sokołowska, Elzbieta Jastrzebska, Zbigniew Brzózka
    Conference:
    Engineering proceedings (rok: 2022, tom: 9th International Symposium on Sensor Science (I3S 2022), strony: 7), Wydawca: MDPI
    Data:
    konferencja 20.06.2022 - 22.06.2022
    Status:
    Published
    DOI:
    10.3390/engproc2022021007 - link to the publication

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