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Information of the project and the call

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New aspects of negative regulation of RNA polymerase III in yeast Saccharomyces cerevisiae

2019/33/B/NZ1/01012

Keywords:

transcription RNA polymerase III tRNA yeast

Descriptors:

  • NZ1_001:
  • NZ3_001:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Maria Cieśla 

Number of co-investigators in the project: 5

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 252 200 PLN

Project start date (Y-m-d): 2020-09-01

Project end date (Y-m-d): 2024-08-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (12)
  1. RNA polymerase III transcription machinery and tRNA processing are regulated by the ubiquitin ligase Rsp5
    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta and Małgorzata Cieśla
    Academic press:
    BBA - Molecular Cell Research (rok: 2025, tom: Volume 1872, Issue 6, strony: 46033), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2025.119993 - link to the publication
  2. Functional suppression of a yeast maf1 deletion mutant by overdose of the N-terminal fragment of the largest RNA polymerase III subunit, C160
    Authors:
    Aleksandra Łopusińska, Malak Farhat, Małgorzata Cieśla
    Academic press:
    Gene (rok: 2024, tom: 930(2024)148839, strony: 46029), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2024.148839 - link to the publication
  1. Rsp5 ubiquitin ligase is implicated in the control of tRNA processing and RNA polymerase III transcription machinery
    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    2nd Polish RNA Biology Meeting (rok: 2025, tom: 2nd Polish RNA Biology Meeting, strony: 181), Wydawca: Uniwersytet Adama Mickiewicza
    Data:
    konferencja 24-27 czerwca 2025
    Status:
    Published
  2. RNA POLYMERASE III TRANSCRIPTION, NOVEL LAYERS OF REGULATION
    Authors:
    Małgorzata Cieśla
    Conference:
    Abstract book - 1st Polish Yeast Conference (rok: 2022, tom: 1st Polish Yeast Conference, strony: 57), Wydawca: Uniwersytet Rzeszowski
    Data:
    konferencja 22-24 czerwca 2022
    Status:
    Published
  3. The connection between Maf1, a negative regulator of RNA polymerase III, and translation in yeast
    Authors:
    Alicja Armatowska, Jan Słupski, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    OddPols-2021-Conference-Book (rok: 2021, tom: OddPols 2021, strony: 101), Wydawca: OddPols 2021
    Data:
    konferencja 14-18 czerwca 2021
    Status:
    Published
  4. The linkage between Maf1-mediated control of tRNA transcription and mRNA translation in yeast Saccharomyces cerevisiae
    Authors:
    Alicja Armatowska, Jan Słupski, Eliza Molestak, Marek Tchórzewski, Stefan Bresson, Małgorzata Cieśla & Magdalena Boguta
    Conference:
    OddPols Abstract Book (rok: 2023, tom: OddPols, strony: 79), Wydawca: OddPols
    Data:
    konferencja 30 maja-2 czerwca 2023
    Status:
    Published
  5. INACTIVATION OF MAF1, THE GENE ENCODING THE NEGATIVE REGULATOR OF RNA POLYMERASE III, HAS MULTIPLE EFFECTS ON TRANSLATION
    Authors:
    Alicja Armatowska, Jan Słupski, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    Abstract book - 1st Polish Yeast Conference (rok: 2022, tom: 1st Polish Yeast Conference, strony: 62), Wydawca: Uniwersytet Rzeszowski
    Data:
    konferencja 22-24 czerwca 2022
    Status:
    Published
  6. Inactivation of Maf1, global negative regulator of tRNA transcription, leads to defects in translation elongation in yeast
    Authors:
    Alicja Armatowska, Małgorzata Cieśla, Michał Świrski, Jan Mikołajczyk, Tomasz W. Turowski, Eliza Molestak, Marek Tchórzewski, Stefan Bresson and Magdalena Boguta
    Conference:
    2nd Polish RNA Biology Meeting (rok: 2025, tom: 2nd Polish RNA Biology Meeting, strony: 115), Wydawca: Uniwersytet Adama Mickiewicza
    Data:
    konferencja 24-27 czerwca 2025
    Status:
    Published
  7. Assembly of RNA polymerase III complex in yeast: novel layer of regulation.
    Authors:
    Małgorzata Cieśla, Tomasz Turowski, Marcin Nowotny, David Tollervey and Magdalena Boguta
    Conference:
    ICY15 PROGRAMME & ABSTRACTS (rok: 2021, tom: ICY15 meets ICYGMB30, strony: 380), Wydawca: International Commission on Yeasts
    Data:
    konferencja 23-27 sierpnia 2021
    Status:
    Published
  8. TRANSCRIPTION EFFICIENCY OF tRNA GENES DEPENDS ON THE RSP5 LIGASE
    Authors:
    Aleksandra Łopusińska, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    Abstract book - 1st Polish Conference (rok: 2022, tom: 1st Polish Yeast Conference, strony: 65), Wydawca: Uniwersytet Rzeszowski
    Data:
    konferencja 22-24 czerwca 2022
    Status:
    Published
  9. Rsp5 ubiquitin ligase is implicated in the control of tRNA processing and RNA polymerase III transcription machinery
    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta, Małgorzata Cieśla
    Conference:
    OddPols-2025 (rok: 2025, tom: Odd Pols 2025, strony: 64), Wydawca: Stowers Institute
    Data:
    konferencja 29 maja-1 czerwca 2025
    Status:
    Published
  10. Functional suppression of maf1 deletion mutant of Saccharomyces cerevisiae by overdose of N-terminal domains of the largest Pol III subunit, C160
    Authors:
    Malak Farhat, Aleksandra Łopusińska, Ewa Leśniewska, Małgorzata Cieśla and Magdalena Boguta
    Conference:
    OddPols Abstract Book (rok: 2023, tom: OddPols, strony: 73), Wydawca: OddPols
    Data:
    konferencja 30 maja-2 czerwca 2023
    Status:
    Published
  11. Regulation of the RNA polymerase III transcription machinery is dependent on the ubiquitin ligase Rsp5
    Authors:
    Aleksandra Łopusińska, Michał Tys, Magdalena Boguta, Małgorzata Cieśla
    Conference:
    PLRNA2023_Abstract_Book (rok: 2023, tom: POLISH RNA BIOLOGY MEETING, strony: 78), Wydawca: International Institute of Molecular and Cell Biology
    Data:
    konferencja 28-30 września 2023
    Status:
    Published
  12. Molecular insights into the regulation of RNA polymerase III transcription machinery by the ubiquitin ligase Rsp5
    Authors:
    Aleksandra Łopusińska, Michal Tys, Magdalena Boguta and Małgorzata Cieśla
    Conference:
    OddPols Abstract Book (rok: 2023, tom: OddPols 2023, strony: 74), Wydawca: OddPols 2023
    Data:
    konferencja 30 maja-2 czerwca 2023
    Status:
    Published