Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of utrophin in cardiomyopathy in Duchenne muscular dystrophy

2019/33/N/NZ3/03064

Keywords:

Duchenne muscular dystrophy DMD utrophin cardiomyopathy dystrophin CRISPR/Cas9 induced pluripotent stem cells genome editing mouse model cardiomyocytes

Descriptors:

  • NZ3_008:
  • NZ1_005:
  • NZ5_007:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Kalina Andrysiak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 17 - announced on 2019-03-15

Amount awarded: 140 000 PLN

Project start date (Y-m-d): 2020-02-24

Project end date (Y-m-d): 2024-02-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
    Authors:
    Kalina Andrysiak, Jacek Stępniewski, Józef Dulak
    Academic press:
    Pflügers Archiv - European Journal of Physiology volume (rok: 2021, tom: 473, strony: 1061–1085), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00424-021-02536-z - link to the publication
  2. Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
    Authors:
    Kalina Andrysiak, Jacek Stępniewski, Józef Dulak
    Academic press:
    Pflügers Archiv - European Journal of Physiology volume (rok: 2021, tom: 473, strony: 1061–1085), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00424-021-02536-z - link to the publication
  3. Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
    Authors:
    Kalina Andrysiak, Jacek Stępniewski, Józef Dulak
    Academic press:
    Pflügers Archiv - European Journal of Physiology volume (rok: 2021, tom: 473, strony: 1061–1085), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00424-021-02536-z - link to the publication
  4. Upregulation of utrophin improves the phenotype of Duchenne muscular dystrophy hiPSC-derived cardiomyocytes
    Authors:
    Kalina Andrysiak, Paweł E. Ferdek, Anna M. Sanetra, Gabriela Machaj, Luisa Schmidt, Izabela Kraszewska, Katarzyna Sarad, Katarzyna Palus-Chramiec, Olga Lis, Marta Targosz-Korecka, Marcus Krüger, Marian H. Lewandowski, Guillem Ylla, Jacek Stępniewski, Józef Dulak
    Academic press:
    Molecular Therapy - Nucleic Acids (rok: 2024, tom: 35, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omtn.2024.102247 - link to the publication

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