Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Adeno-associated virus (AAV)-based gene therapy in the regeneration of optic nerve after ischemic stroke.

2019/33/B/NZ4/00587

Keywords:

ischemic stroke neuroregeneration perinuclear signalosomes calcineurin/NFAT signaling pathway optic neuropathy gene therapy

Descriptors:

  • NZ5_007:
  • NZ3_007:
  • NZ4_009:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Boczek 

Number of co-investigators in the project: 5

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 491 740 PLN

Project start date (Y-m-d): 2020-07-28

Project end date (Y-m-d): 2025-07-27

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Perinuclear compartment controls calcineurin/MEF2 signaling for axonal outgrowth of hippocampal neurons
    Authors:
    Mackiewicz J, Lisek M, Tomczak J, Sakowicz A, Guo F, Boczek T.
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2024, tom: 17:1494160, strony: 17:1494160), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2024.1494160 - link to the publication
  2. NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury
    Authors:
    Mackiewicz J, Tomczak J, Lisek M, Sakowicz A, Guo F, Boczek T.
    Academic press:
    Molecular Neurobiology (rok: 2024, tom: 61(11):9383-9401, strony: 61(11):9383-9401), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12035-024-04129-0 - link to the publication
  3. Real-Time FRET-Based Measurements of Ca2+/PKA Dynamics in Plasma Membrane Microdomains of Primary Hippocampal Neurons
    Authors:
    Sobolczyk-Prawda M, Boczek T.
    Academic press:
    Current Protocols (rok: 2024, tom: 4(5):e1048, strony: 4(5):e1048), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cpz1.1048 - link to the publication
  4. Astrocytic Calcium and cAMP in Neurodegenerative Diseases
    Authors:
    Sobolczyk M, Boczek T.
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2022, tom: 16:889939, strony: 16:889939), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2022.889939 - link to the publication
  5. AKAP6 controls NFATc4 activity for BDNF-mediated neuroprotection
    Authors:
    Mackiewicz J, Tomczak J, Lisek M, Guo F, Boczek T.
    Academic press:
    Molecular Brain (rok: 2024, tom: 17(1):85, strony: 17(1):85), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13041-024-01157-8 - link to the publication
  6. Targeting CaN/NFAT in Alzheimer's brain degeneration
    Authors:
    Mackiewicz J, Lisek M, Boczek T
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14:1281882, strony: 14:1281882), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1281882 - link to the publication
  7. A-kinase anchoring protein–mediated compartmentalization of pro-survival signaling in the retina
    Authors:
    Mackiewicz J, Boczek T
    Academic press:
    Neural Regeneration Research (rok: 2024, tom: 20(2):479-480, strony: 20(2):479-480), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.4103/NRR.NRR-D-24-00168 - link to the publication

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