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Physico-chemical principles of antioxidant action: from solvent effect and mechanistic studies to interfacial phenomena in biologically relevant systems.

2018/31/B/ST4/02354

Keywords

Descriptors

  • ST4_13: Chemia fizyczna układów biologicznych
  • ST4_14: Reakcje chemiczne: mechanizmy, termodynamika, kinetyka i kataliza

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Uniwersytet Warszawski, Wydział Chemii

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Grzegorz Robert Litwinienko

Number of co-investigators in the project: 9

Call

OPUS 16 – announced on 2018-09-14

Amount awarded
1 826 000 PLN
Project start date
2019-10-01
Project end date
2024-04-30
Project duration
55 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (9)

  1. Mutual Activation of Two Radical Trapping Agents: Unusual win-Win Synergy of Resveratrol and TEMPO during Scavenging of dpph• Radical in Methanol

    Authors:
    Konopko, A., Litwinienko, G.
    Academic press:
    Journal of Organic Chemistry (year: 2022, volume: 87, pages: 15530-15538), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.joc.2c02080 – link to the publication

  2. Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups

    Authors:
    7.Lewińska, A., Przybylski, P., Adamczyk-Grochala, J., Błoniarz, D., Litwinienko, G., Wnuk, M.
    Academic press:
    Cancers (year: 2022, volume: 14, pages: 605), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14030605 – link to the publication

  3. Mutation Status and Glucose Availability Affect the Response to Mitochondria-Targeted Quercetin Derivative in Breast Cancer Cells

    Authors:
    P. Przybylski, A. Lewińska, I. Rzeszutek, D. Błoniarz, A. Moskal, G. Betlej, A. Deręgowska, M. Cybularczyk-Cecotka, T. Szmatoła, G. Litwinienko*, M. Wnuk*
    Academic press:
    Cancers (year: 2023, volume: 15, pages: 15235614), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15235614 – link to the publication

  4. Concentration-dependent HAT/ET mechanism of the reaction of phenols with 2,2-diphenyl-1-picrylhydrazyl (dpph˙) in methanol

    Authors:
    Przybylski, P., Konopko, A., Łętowski, P., Jodko-Piórecka, K., Litwinienko, G.
    Academic press:
    RSC Advances (year: 2022, volume: 12, pages: 8131-8136), Publisher: RSC
    Status:
    Published
    DOI:
    10.1039/d2ra01033j – link to the publication

  5. Hydrogen Atom Transfer from HOO to ortho-Quinones Explains the Antioxidant Activity of Polydopamine

    Authors:
    Yafang Guo, Andrea Baschieri, Fabio Mollica, Luca Valgimigli, Jakub Cedrowski, Grzegorz Litwinienko, and Riccardo Amorati
    Academic press:
    Angewandte Chemie Int. Ed. (year: 2021, volume: 60, pages: 15220-15224), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.202101033 – link to the publication

  6. Antioxidant activity of two edible isothiocyanates: sulforaphane and erucin is due to their thermal decomposition to sulfenic acids and methylsulfinyl radicals

    Authors:
    Cedrowski, J., Dąbrowa, K., Przybylski P., K., Krogul-Sobczak, A., Litwinienko, G.
    Academic press:
    Food Chemistry (year: 2021, volume: 353, pages: 129213), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.foodchem.2021.129213 – link to the publication

  7. Antiradical Activity of Dopamine, L‑DOPA, Adrenaline, and Noradrenaline in Water/Methanol and in Liposomal Systems

    Authors:
    Katarzyna Jodko-Piórecka, Bożena Sikora, Monika Kluzek, Paweł Przybylski, and Grzegorz Litwinienko
    Academic press:
    Journal of Organic Chemistry (year: 2022, volume: 87, pages: 1791-1804), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.joc.1c02308 – link to the publication

  8. Unexpected Role of pH and Microenvironment on the Antioxidant and Synergistic Activity of Resveratrol in Model Micellar and Liposomal Systems

    Authors:
    Adrian Konopko and Grzegorz Litwinienko
    Academic press:
    Journal of Organic Chemistry (year: 2022, volume: 87, pages: 1698-1709), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.joc.1c01801 – link to the publication

  9. A Lesson Learnt from Food Chemistry—Elevated Temperature Triggers the Antioxidant Action of Two Edible Isothiocyanates: Erucin and Sulforaphane.

    Authors:
    Cedrowski, J.; Dąbrowa, K.; Krogul-Sobczak, A.; Litwinienko, G.
    Academic press:
    Antioxidants (year: 2020, volume: 9, pages: 1090), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9111090 – link to the publication

Book publications / chapters in book publications (2)

  1. Antioxidant Activity of Edible Isothiocyanates

    Authors:
    Jakub Cedrowski, Jacek Grebowski, and Grzegorz Litwinienko
    Book:
    Lipid Oxidation in Food and Biological Systems (year: 2022, volume: 0, pages: 277-303), Publisher: Springer Nature Switzerland AG
    Status:
    Published

  2. Fluorescent Probes for Monitoring Oxidation of Lipids and Assessment of Antioxidant Activity

    Authors:
    Jarosław Kusio and Grzegorz Litwinienko
    Book:
    Lipid Oxidation in Food and Biological Systems (year: 2022, volume: 1, pages: 49-91), Publisher: Springer Nature Switzerland AG
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski