Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Physico-chemical principles of antioxidant action: from solvent effect and mechanistic studies to interfacial phenomena in biologically relevant systems.

2018/31/B/ST4/02354

Keywords:

free radicals reaction mechanisms peroxidation oxidative stress biomembranes lipids antioxidants

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST4_14: Catalysis

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Litwinienko 

Number of co-investigators in the project: 9

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 826 000 PLN

Project start date (Y-m-d): 2019-10-01

Project end date (Y-m-d): 2024-04-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  • Book publications / chapters in book publications (2)
  1. A Lesson Learnt from Food Chemistry—Elevated Temperature Triggers the Antioxidant Action of Two Edible Isothiocyanates: Erucin and Sulforaphane.
    Authors:
    Cedrowski, J.; Dąbrowa, K.; Krogul-Sobczak, A.; Litwinienko, G.
    Academic press:
    Antioxidants (rok: 2020, tom: 9, strony: 1090), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9111090 - link to the publication
  2. Unexpected Role of pH and Microenvironment on the Antioxidant and Synergistic Activity of Resveratrol in Model Micellar and Liposomal Systems
    Authors:
    Adrian Konopko and Grzegorz Litwinienko
    Academic press:
    Journal of Organic Chemistry (rok: 2022, tom: 87, strony: 1698-1709), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.joc.1c01801 - link to the publication
  3. Concentration-dependent HAT/ET mechanism of the reaction of phenols with 2,2-diphenyl-1-picrylhydrazyl (dpph˙) in methanol
    Authors:
    Przybylski, P., Konopko, A., Łętowski, P., Jodko-Piórecka, K., Litwinienko, G.
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 8131-8136), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d2ra01033j - link to the publication
  4. Hydrogen Atom Transfer from HOO to ortho-Quinones Explains the Antioxidant Activity of Polydopamine
    Authors:
    Yafang Guo, Andrea Baschieri, Fabio Mollica, Luca Valgimigli, Jakub Cedrowski, Grzegorz Litwinienko, and Riccardo Amorati
    Academic press:
    Angewandte Chemie Int. Ed. (rok: 2021, tom: 60, strony: 15220-15224), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.202101033 - link to the publication
  5. Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups
    Authors:
    7.Lewińska, A., Przybylski, P., Adamczyk-Grochala, J., Błoniarz, D., Litwinienko, G., Wnuk, M.
    Academic press:
    Cancers (rok: 2022, tom: 14, strony: 605), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14030605 - link to the publication
  6. Antioxidant activity of two edible isothiocyanates: sulforaphane and erucin is due to their thermal decomposition to sulfenic acids and methylsulfinyl radicals
    Authors:
    Cedrowski, J., Dąbrowa, K., Przybylski P., K., Krogul-Sobczak, A., Litwinienko, G.
    Academic press:
    Food Chemistry (rok: 2021, tom: 353, strony: 129213), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.foodchem.2021.129213 - link to the publication
  7. Antiradical Activity of Dopamine, L‑DOPA, Adrenaline, and Noradrenaline in Water/Methanol and in Liposomal Systems
    Authors:
    Katarzyna Jodko-Piórecka, Bożena Sikora, Monika Kluzek, Paweł Przybylski, and Grzegorz Litwinienko
    Academic press:
    Journal of Organic Chemistry (rok: 2022, tom: 87, strony: 1791-1804), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.joc.1c02308 - link to the publication
  8. Mutual Activation of Two Radical Trapping Agents: Unusual "win-Win Synergy" of Resveratrol and TEMPO during Scavenging of dpph• Radical in Methanol
    Authors:
    Konopko, A., Litwinienko, G.
    Academic press:
    Journal of Organic Chemistry (rok: 2022, tom: 87, strony: 15530-15538), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.joc.2c02080 - link to the publication
  1. Antioxidant Activity of Edible Isothiocyanates
    Authors:
    Jakub Cedrowski, Jacek Grebowski, and Grzegorz Litwinienko
    Book:
    Lipid Oxidation in Food and Biological Systems (rok: 2022, ), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
  2. Fluorescent Probes for Monitoring Oxidation of Lipids and Assessment of Antioxidant Activity
    Authors:
    Jarosław Kusio and Grzegorz Litwinienko
    Book:
    Lipid Oxidation in Food and Biological Systems (rok: 2022, tom: 1, strony: 49-91), Wydawca: Springer Nature Switzerland AG
    Status:
    Published

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