Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Nowel polymeric nanoparticles for pulmonary nucleic acid therapy - synthesis, toxicological analysis and biological/therapeutic assesment

2018/31/F/NZ5/03454

Keywords:

Nanotechnology nucleic acids drug delivery pulmonary diseases

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ1_3: Biophysics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bryszewska 

Number of co-investigators in the project: 6

Call: BEETHOVEN LIFE 1 - announced on 2018-09-14

Amount awarded: 1 039 710 PLN

Project start date (Y-m-d): 2020-01-31

Project end date (Y-m-d): 2024-12-30

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Heterofunctionalized polyphenolic dendrimers decorated with caffeic acid: Synthesis, characterization and antioxidant activity,
    Authors:
    Marika Grodzicka, Cornelia E. Pena-Gonzalez, Paula Ortega, Sylwia Michlewska, Rebeca Lozano, Maria Bryszewska, Francisco Javier de la Mata, Maksim Ionov,
    Academic press:
    Sustainable Materials and Technologies (rok: 2022, tom: 33, strony: e0049, 1-14), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.susmat.2022.e00497 - link to the publication
  2. Combined therapy of ruthenium dendrimers and anti-cancer drugs against human leukemic cells
    Authors:
    S. Michlewska, M. Maroto, M. Hołota,M. Kubczak, N. Sanz Del Olmo , P. Ortega, D. Shcharbin, F. J. de la Mata, M. Bryszewska, M. Ionov
    Academic press:
    Dalton Trans. (rok: 2021, tom: 50/27, strony: 9500-9511), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1dt01388b - link to the publication
  3. Unmodified and tyrosine-modified polyethylenimines as potential carriers for siRNA: Biophysical characterization and toxicity
    Authors:
    M. Kubczak , S. Michlewska, M. Karimov, A. Ewe, S. Noske, A. Aigner, M. Bryszewska, M. Ionov
    Academic press:
    International Journal of Pharmaceutics (rok: 2022, tom: 614, strony: 121468), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2022.121468 - link to the publication
  4. Comparison of tyrosine-modified low molecular weight branched and linear polyethylenimines for siRNA delivery.
    Authors:
    M. Kubczak, S. Michlewska, M. Karimov, A. Ewe, A. Aigner, M. Bryszewska, M. Ionov.
    Academic press:
    Nanotoxicology (rok: 2023, tom: 16, strony: 867*882), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17435390.2022.2159891 - link to the publication
  5. Nanoparticles for local delivery of siRNA in lung therapy
    Authors:
    M. Kubczak, S. Michlewska, M. Bryszewska, A. Aigner, M. Ionov
    Academic press:
    Advanced Drug Delivery Reviews (rok: 2021, tom: 179, strony: 114,38), Wydawca: ELSIVIER
    Status:
    Published
    DOI:
    10.1016/j.addr.2021.114038 - link to the publication
  6. The effect of novel tyrosine-modified polyethyleneimines on human albumin structure - Thermodynamic and spectroscopic study.
    Authors:
    M. Kubczak, M. Grodzicka, S. Michlewska, M. Karimov, A. Ewe, A. Aigner, M. Bryszewska, M. Ionov.
    Academic press:
    Coll. Surf. B: Biointerfaces (rok: 2023, tom: 227, strony: 113359), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2023.113359. - link to the publication
  1. Oddziaływanie dendrymerów zawierających atomy miedzi z aminotransferazą asparaginianową (AST)
    Authors:
    M. Grodzicka, M. Kubczak, S. Michlewska, M. Ionov, M. Bryszewska
    Conference:
    XIII Interdyscyplinarna Konferencja naukowa TYGIEL 2021 "Interdyscyplinarność kluczem do rozwoju" (rok: 2021, ), Wydawca: Wydawnictwo Naukowe TYGIEL sp. z o.o.
    Data:
    konferencja 25-28 marca 2021
    Status:
    Published

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