Zmiana języka

Projects search

Epigenomic, immunogenetic and proteomic strategies for identification of NK cell determinants of prognostic value for patients undergoing allogeneic transplantation of hematopoietic stem cells - a multicenter study

2018/31/B/NZ2/03065

Keywords

Descriptors

  • NZ2_6: Immunogenetyka

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Katarzyna Maria Bogunia-Kubik

Number of co-investigators in the project: 17

Call

OPUS 16 – announced on 2018-09-14

Amount awarded
1 781 500 PLN
Project start date
2019-10-03
Project end date
2024-10-02
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (15)

  1. Unravelling the potential of TIM-3 gene polymorphism in allogeneic hematopoietic stem cell transplantation - a preliminary study.

    Authors:
    Biały S, Siemaszko J, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Transplant Immunology (year: 2024, volume: 85, pages: 102084), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trim.2024.102084. – link to the publication

  2. Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation.

    Authors:
    Siemaszko J, Łacina P, Szymczak D, Szeremet A, Majcherek M, Czyż A, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Human Immunology (year: 2024, volume: 85, pages: 111147), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.humimm.2024.111147. – link to the publication

  3. Donor genetic determinant of thymopoiesis, rs2204985, and stem cell transplantation outcome in a multipopulation cohort.

    Authors:
    Nihtilä J, Salmenniemi U, Itälä-Remes M, Crossland R, Gallardo D, Bogunia-Kubik K, Lacina P, Bieniaszewska M, Giebel S, Hyvärinen K, Kekäläinen E, Ritari J, Partanen J.
    Academic press:
    Human Immunology (year: 2023, volume: 85, pages: 110791), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.humimm.2024.110791. – link to the publication

  4. Activating NKG2C receptor - functional characteristics and current strategies in clinical applications.

    Authors:
    Siemaszko J, Marzec-Przyszlak A, Bogunia-Kubik K.
    Academic press:
    Arch Immunol Ther Exp (Warsz). (year: 2023, volume: 71, pages: 9), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-023-00674-z – link to the publication

  5. Differential expression of miRNAs from extracellular vesicles in chronic graft-versus-host disease: A preliminary study.

    Authors:
    Łacina P, Crossland RE, Wielińska J, Czyż A, Szeremet A, Ussowicz M, Wróbel T, Dickinson AM, Bogunia-Kubik K.
    Academic press:
    Advances in Clinical and Experimental Medicine (year: 2023, volume: 32, pages: 539-544), Publisher: Wroclaw Medical University Press
    Status:
    Published
    DOI:
    10.17219/acem/155373 – link to the publication

  6. MICB Genetic Variants and Its Protein Soluble Level Are Associated with the Risk of Chronic GvHD and CMV Infection after Allogeneic HSCT.

    Authors:
    Siemaszko J, Dratwa M, Szeremet A, Majcherek M, Czyż A, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Arch Immunol Ther Exp (Warsz). (year: 2024, volume: 72, pages: 46031), Publisher: Sciendo
    Status:
    Published
    DOI:
    10.2478/aite-2024-0012. – link to the publication

  7. Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.

    Authors:
    Siemaszko J, Łacina P, Szymczak D, Szeremet A, Majcherek M, Czyż A, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Frontiers in Immunology (year: 2023, volume: 14, pages: 1227897), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1227897 – link to the publication

  8. Complex interactions of cellular players in chronic Graft-versus-Host Disease.

    Authors:
    Gail LM, Schell KJ, Łacina P, Strobl J, Bolton SJ, Ulriksen ES, Bogunia-Kubik K, Greinix H, Crossland RE, Inngjerdingen M, Stary G.
    Academic press:
    Frontiers in Immunology (year: 2023, volume: 14, pages: 1199422), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1199422 – link to the publication

  9. The impact of NKG2A and NKG2D receptors and HLA-E and MICA ligands polymorphisms on posttransplant complications after paediatric allogeneic HSCT: a single-centre experience.

    Authors:
    Siemaszko J, Ussowicz M, Rybka B, Ryczan-Krawczyk R, Kalwak K, Bogunia-Kubik K.
    Academic press:
    Frontiers in Genetics (year: 2023, volume: 14, pages: 1186123), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fgene.2023.1186123 – link to the publication

  10. Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity.

    Authors:
    Nihtilä J, Penna L, Salmenniemi U, Itälä-Remes M, Crossland RE, Gallardo D, Bogunia-Kubik K, Lacina P, Bieniaszewska M, Giebel S, Karjalainen K, Jahan F, Kerkelä E, Hyvärinen K, Koskela S, Ritari J, Partanen J.
    Academic press:
    Scientific Reports (year: 2024, volume: 14, pages: 26988), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-78619-5. – link to the publication

  11. Non-KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells.

    Authors:
    Bogunia-Kubik K, Łacina P.
    Academic press:
    International Journal of Immunogenetics (year: 2021, volume: 48, pages: 157-171), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/iji.12523 – link to the publication

  12. Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease.

    Authors:
    Crossland RE, Perutelli F, Bogunia-Kubik K, Mooney N, Milutin Gašperov N, Pučić-Baković M, Greinix H, Weber D, Holler E, Pulanić D, Wolff D, Dickinson AM, Inngjerdingen M, Grce M.
    Academic press:
    Frontiers in Immunology (year: 2020, volume: 11, pages: 602547), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.602547 – link to the publication

  13. Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.

    Authors:
    Partanen J, Hyvärinen K, Bickeböller H, Bogunia-Kubik K, Crossland RE, Ivanova M, Perutelli F, Dressel R.
    Academic press:
    Frontiers in Immunology (year: 2020, volume: 11, pages: 575492), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.575492 – link to the publication

  14. Telomere length and telomerase reverse transcriptase gene polymorphism as potential markers of complete chimerism and GvHD development after allogeneic haematopoietic stem cell transplantation.

    Authors:
    Dratwa-Kuzmin M, Lacina P, Wysoczanska B, Kilinska D, Siemaszko J, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Bogunia-Kubik K.
    Academic press:
    Journal of Cancer Research and Clinical Oncology (year: 2025, volume: 151, pages: 109), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00432-025-06160-7 – link to the publication

  15. NKG2D Natural Killer Cell Receptor - A Short Description and Potential Clinical Application

    Authors:
    Jagoda Siemaszko, Aleksandra Marzec-Przyszlak, Katarzyna Bogunia-Kubik
    Academic press:
    Cells (year: 2021, volume: 10, pages: 1420), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061420 – link to the publication

« New search

Graphic design and implementation: Jakub Piotrowski