Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Epigenomic, immunogenetic and proteomic strategies for identification of NK cell determinants of prognostic value for patients undergoing allogeneic transplantation of hematopoietic stem cells - a multicenter study

2018/31/B/NZ2/03065

Keywords:

allogeneic transplantation of hematopoietic stem cells genetic variability of NK cells receptors and their ligands in donors and recipients at allele genotype and haplotype level of non-classical HLA NCR2-3 (chromosome 6) CD94 NKG2A-F (chromosome 12) ILT2-4 NCR1 (chromosome 19) encoding genes miRNA repertoire recipient metabolomics profile post-transplant complications GvHD CMV reactivation

Descriptors:

  • NZ2_6:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Katarzyna Maria Bogunia-Kubik 

Number of co-investigators in the project: 17

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 781 500 PLN

Project start date (Y-m-d): 2019-10-03

Project end date (Y-m-d): 2024-10-02

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (15)
  1. Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation.
    Authors:
    Siemaszko J, Łacina P, Szymczak D, Szeremet A, Majcherek M, Czyż A, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Human Immunology (rok: 2024, tom: 85, strony: 111147), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.humimm.2024.111147. - link to the publication
  2. Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease.
    Authors:
    Crossland RE, Perutelli F, Bogunia-Kubik K, Mooney N, Milutin Gašperov N, Pučić-Baković M, Greinix H, Weber D, Holler E, Pulanić D, Wolff D, Dickinson AM, Inngjerdingen M, Grce M.
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 11, strony: 602547), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.602547 - link to the publication
  3. Telomere length and telomerase reverse transcriptase gene polymorphism as potential markers of complete chimerism and GvHD development after allogeneic haematopoietic stem cell transplantation.
    Authors:
    Dratwa-Kuzmin M, Lacina P, Wysoczanska B, Kilinska D, Siemaszko J, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Bogunia-Kubik K.
    Academic press:
    Journal of Cancer Research and Clinical Oncology (rok: 2025, tom: 151, strony: 109), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00432-025-06160-7 - link to the publication
  4. Activating NKG2C receptor - functional characteristics and current strategies in clinical applications.
    Authors:
    Siemaszko J, Marzec-Przyszlak A, Bogunia-Kubik K.
    Academic press:
    Arch Immunol Ther Exp (Warsz). (rok: 2023, tom: 71, strony: 9), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-023-00674-z - link to the publication
  5. MICB Genetic Variants and Its Protein Soluble Level Are Associated with the Risk of Chronic GvHD and CMV Infection after Allogeneic HSCT.
    Authors:
    Siemaszko J, Dratwa M, Szeremet A, Majcherek M, Czyż A, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Arch Immunol Ther Exp (Warsz). (rok: 2024, tom: 72, strony: 46031), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/aite-2024-0012. - link to the publication
  6. Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.
    Authors:
    Siemaszko J, Łacina P, Szymczak D, Szeremet A, Majcherek M, Czyż A, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 1227897), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1227897 - link to the publication
  7. Unravelling the potential of TIM-3 gene polymorphism in allogeneic hematopoietic stem cell transplantation - a preliminary study.
    Authors:
    Biały S, Siemaszko J, Sobczyk-Kruszelnicka M, Fidyk W, Solarska I, Nasiłowska-Adamska B, Skowrońska P, Bieniaszewska M, Tomaszewska A, Basak GW, Giebel S, Wróbel T, Bogunia-Kubik K.
    Academic press:
    Transplant Immunology (rok: 2024, tom: 85, strony: 102084), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trim.2024.102084. - link to the publication
  8. Differential expression of miRNAs from extracellular vesicles in chronic graft-versus-host disease: A preliminary study.
    Authors:
    Łacina P, Crossland RE, Wielińska J, Czyż A, Szeremet A, Ussowicz M, Wróbel T, Dickinson AM, Bogunia-Kubik K.
    Academic press:
    Advances in Clinical and Experimental Medicine (rok: 2023, tom: 32, strony: 539-544), Wydawca: Wroclaw Medical University Press
    Status:
    Published
    DOI:
    10.17219/acem/155373 - link to the publication
  9. Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity.
    Authors:
    Nihtilä J, Penna L, Salmenniemi U, Itälä-Remes M, Crossland RE, Gallardo D, Bogunia-Kubik K, Lacina P, Bieniaszewska M, Giebel S, Karjalainen K, Jahan F, Kerkelä E, Hyvärinen K, Koskela S, Ritari J, Partanen J.
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 26988), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-78619-5. - link to the publication
  10. NKG2D Natural Killer Cell Receptor - A Short Description and Potential Clinical Application
    Authors:
    Jagoda Siemaszko, Aleksandra Marzec-Przyszlak, Katarzyna Bogunia-Kubik
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1420), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061420 - link to the publication
  11. Complex interactions of cellular players in chronic Graft-versus-Host Disease.
    Authors:
    Gail LM, Schell KJ, Łacina P, Strobl J, Bolton SJ, Ulriksen ES, Bogunia-Kubik K, Greinix H, Crossland RE, Inngjerdingen M, Stary G.
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 1199422), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1199422 - link to the publication
  12. Non-KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells.
    Authors:
    Bogunia-Kubik K, Łacina P.
    Academic press:
    International Journal of Immunogenetics (rok: 2021, tom: 48, strony: 157-171), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/iji.12523 - link to the publication
  13. Donor genetic determinant of thymopoiesis, rs2204985, and stem cell transplantation outcome in a multipopulation cohort.
    Authors:
    Nihtilä J, Salmenniemi U, Itälä-Remes M, Crossland R, Gallardo D, Bogunia-Kubik K, Lacina P, Bieniaszewska M, Giebel S, Hyvärinen K, Kekäläinen E, Ritari J, Partanen J.
    Academic press:
    Human Immunology (rok: 2023, tom: 85, strony: 110791), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.humimm.2024.110791. - link to the publication
  14. The impact of NKG2A and NKG2D receptors and HLA-E and MICA ligands polymorphisms on posttransplant complications after paediatric allogeneic HSCT: a single-centre experience.
    Authors:
    Siemaszko J, Ussowicz M, Rybka B, Ryczan-Krawczyk R, Kalwak K, Bogunia-Kubik K.
    Academic press:
    Frontiers in Genetics (rok: 2023, tom: 14, strony: 1186123), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fgene.2023.1186123 - link to the publication
  15. Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.
    Authors:
    Partanen J, Hyvärinen K, Bickeböller H, Bogunia-Kubik K, Crossland RE, Ivanova M, Perutelli F, Dressel R.
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 11, strony: 575492), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.575492 - link to the publication

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