Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Non-spherical ceragenin-based nanosystems as an innovative approach for antimicrobial treatment, immunomodulation enhancement and tissue regeneration

2018/31/B/NZ6/02476

Keywords:

antimicrobial activity immunomodulatory activity regenerative properties nanoantibiotics ceragenins

Descriptors:

  • NZ6_8:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Robert Bucki 

Number of co-investigators in the project: 10

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 657 580 PLN

Project start date (Y-m-d): 2019-07-08

Project end date (Y-m-d): 2024-07-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (3)
  1. Rod-shaped gold nanoparticles exert potent candidacidal activity and decrease the adhesion of fungal cells
    Authors:
    Piktel E, Suprewicz Ł, Depciuch J, Cieśluk M, Chmielewska S, Durnaś B, Król G, Wollny T, Deptuła P, Kochanowicz J, Kułakowska A, Fiedoruk K, Maximenko A, Parlinska-Wojtan M, Bucki R
    Academic press:
    Nanomedicine (rok: 2020, tom: 15, strony: 0), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/nnm-2020-0324 - link to the publication
  2. Varied‑shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
    Authors:
    Piktel E, Suprewicz Ł, Depciuch J, Chmielewska S, Skłodowski K, Daniluk T, Król G, Kołat-Brodecka P, Bijak P, Pajor-Świerzy A, Fiedoruk K, Parlińska-Wojtan M, Bucki R
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 20pp, Article ID 12546), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-91847-3 - link to the publication
  3. Ceragenin-coated non-spherical gold nanoparticles as novel candidacidal agents
    Authors:
    Skłodowski K, Chmielewska SJ, Depciuch J, Deptuła P, Piktel E, Daniluk T, Zakrzewska M, Czarnowski M, Ciesluk M, Durnaś B, Parlińska-Wojtan M, Savage PB, Bucki R
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 21pp, Article ID 1940), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13111940 - link to the publication
  4. Targeting bacteria causing otitis media using nanosystems containing nonspherical gold nanoparticles and ceragenins
    Authors:
    Prasad SV, Piktel E, Depciuch J, Maximenko A, Suprewicz Ł, Daniluk T, Spałek J, Wnorowska U, Zieliński PM, Parlińska-Wojtan M, Savage PB, Okła S, Fieodruk K, Bucki R
    Academic press:
    Nanomedicine (rok: 2021, tom: 16, strony: 2657-2678), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/nnm-2021-0370 - link to the publication
  5. Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response
    Authors:
    Suprewicz Ł, Szczepanski A, lenart M, Piktel E, Fiedoruk K, Barreto-Duran E, Kula-Pacurar A, Savage PB, Milewska A, Bucki R, Pyrć K
    Academic press:
    Antiviral Research (rok: 2023, tom: 217, strony: 12pp), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.antiviral.2023.105676 - link to the publication
  6. Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response
    Authors:
    Suprewicz Ł, Szczepanski A, lenart M, Piktel E, Fiedoruk K, Barreto-Duran E, Kula-Pacurar A, Savage PB, Milewska A, Bucki R, Pyrć K
    Academic press:
    Antiviral Research (rok: 2023, tom: 217, strony: 12pp), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.antiviral.2023.105676 - link to the publication
  7. Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89
    Authors:
    Prasad SV, Fiedoruk K, Zakrzewska M, Savage PB, Bucki R
    Academic press:
    Microbiology Spectrum (rok: 2023, tom: 11, strony: 10pp), Wydawca: American Society of Microbiology
    Status:
    Published
    DOI:
    10.1128/spectrum.01215-23 - link to the publication
  8. Bactericidal properties of rod-, peanut-, and star-shaped gold nanoparticles coated with ceragenin CSA-131 against multidrug-resistant bacterial strains
    Authors:
    Chmielewska SJ, Skłodowski K, Depciuch J, Deptuła P, Piktel E, Fiedoruk K, Kot P, Paprocka P, Fortunka K, Wollny T, Wolak P, Parlińska-Wojtan M, Savage PB, Bucki R
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 27pp, Article ID 425), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13030425 - link to the publication
  1. Kompleksy inkluzyjne ceragenin z cyklodekstryną jako nowe nanoantybiotyki
    Authors:
    Piktel E, Depciuch J, Daniluk T, Savage PB, Parlińska-Wojtan M, Bucki R
    Conference:
    XXIX Ogólnopolski Zjazd Polskiego Towarzystwa Mikrobiologów (rok: 2022, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 15-17.09.2022
    Status:
    Published
  2. Aktywność przeciwbakteryjna ceragenin może być regulowana stężeniem jonów wodorowych
    Authors:
    Wnorowska U, Daniluk T, Durnaś B, Piktel E, Savage PB, Bucki R
    Conference:
    XXIX Ogólnopolski Zjazd Polskiego Towarzystwa Mikrobiologów (rok: 2022, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 15-17.09.2022
    Status:
    Published
  3. Antimicrobial activity of gold nanoparticles coated with ceragenin CSA-13 against highly-virulent and antibiotic-resistant Acinetobacter baumannii
    Authors:
    Skłodowski K, Chmielewska S, Suprewicz Ł, Wollny T, Król G, Depciuch J, Parlińska-Wojtan M, Savage PB, Bucki R
    Conference:
    40TH Annual Meeting of the European Society for Paediatric Infectious Diseases. Athens & Online (rok: 2022, ), Wydawca: ESPID and ESPID Fundation
    Data:
    konferencja 9-13.05.2022
    Status:
    Published

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