Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Non-spherical ceragenin-based nanosystems as an innovative approach for antimicrobial treatment, immunomodulation enhancement and tissue regeneration

2018/31/B/NZ6/02476

Keywords:

antimicrobial activity immunomodulatory activity regenerative properties nanoantibiotics ceragenins

Descriptors:

  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Robert Bucki 

Number of co-investigators in the project: 10

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 657 580 PLN

Project start date (Y-m-d): 2019-07-08

Project end date (Y-m-d): 2024-07-07

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (17)
  • Articles in post-conference publications (3)
  1. Assessment of ceragenins in prevention of damage to voice prostheses caused by Candida biofilm formation
    Authors:
    Spałek J, Daniluk T, Godlewski A, Deptuła P, Wnorowska U, Ziembicka D, Cieśluk M, Fiedoruk K, Ciborowski M, Krętowski A, Góźdź S, Durnaś B, Savage PB, Okła S, Bucki R
    Academic press:
    Pathogens (rok: 2021, tom: 10, strony: 13pp, Article ID 1371), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens10111371 - link to the publication
  2. Cathelicidin LL-37 in Health and Diseases of the Oral Cavity
    Authors:
    Tokajuk J, Deptuła P, Piktel E, Daniluk T, Chmielewska S, Wollny T, Wolak P, Fiedoruk K, Bucki R
    Academic press:
    Biomedicines (rok: 2022, tom: 10, strony: 1086), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines10051086 - link to the publication
  3. Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89
    Authors:
    Prasad SV, Fiedoruk K, Zakrzewska M, Savage PB, Bucki R
    Academic press:
    Microbiology Spectrum (rok: 2023, tom: 11, strony: 10pp), Wydawca: American Society of Microbiology
    Status:
    Published
    DOI:
    10.1128/spectrum.01215-23 - link to the publication
  4. NDM-1 carbapenemase-producing Enterobacteriaceae are highly susceptible to ceragenins CSA-13, CSA-44, and CSA-131
    Authors:
    Chmielewska SJ, Skłodowski K, Piktel E, Suprewicz Ł, Fiedoruk K, Daniluk K, Wolak P, Savage PB, Bucki R
    Academic press:
    Infection and Drug Resistance (rok: 2020, tom: 13, strony: 3277—3294), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IDR.S261579 - link to the publication
  5. Rod-shaped gold nanoparticles exert potent candidacidal activity and decrease the adhesion of fungal cells
    Authors:
    Piktel E, Suprewicz Ł, Depciuch J, Cieśluk M, Chmielewska S, Durnaś B, Król G, Wollny T, Deptuła P, Kochanowicz J, Kułakowska A, Fiedoruk K, Maximenko A, Parlinska-Wojtan M, Bucki R
    Academic press:
    Nanomedicine (rok: 2020, tom: 15, strony: 0), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/nnm-2020-0324 - link to the publication
  6. Sphingosine-1-Phosphate-Triggered Expression of Cathelicidin LL-37 Promotes the Growth of Human Bladder Cancer Cells
    Authors:
    Wollny T, Wnorowska U, Piktel E, Suprewicz Ł, Król G, Głuszek K, Góźdź S, Kopczyński J, Bucki R
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 7443), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23137443 - link to the publication
  7. Varied‑shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices
    Authors:
    Piktel E, Suprewicz Ł, Depciuch J, Chmielewska S, Skłodowski K, Daniluk T, Król G, Kołat-Brodecka P, Bijak P, Pajor-Świerzy A, Fiedoruk K, Parlińska-Wojtan M, Bucki R
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 20pp, Article ID 12546), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-91847-3 - link to the publication
  8. Biocompatible materials in otorhinolaryngology and their antibacterial properties
    Authors:
    Spałek J, Ociepa P, Deptuła P, Piktel E, Daniluk T, Król G, Góźdź S, Bucki R, Okła S
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 23pp, Article ID: 2575), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052575 - link to the publication
  9. Ceragenin CSA-44 as a Means to Control the Formation of the Biofilm on the Surface of Tooth and Composite Fillings
    Authors:
    Tokajuk J, Deptuła P, Chmielewska SJ, Skłodowski K, Mierzejewsta ŻA, Grądzka-Dahlke M, Tołstoj A, Daniluk T, Paprocka P, Savage PB, Bucki R
    Academic press:
    Pathogens (rok: 2022, tom: 11, strony: 491), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens11050491 - link to the publication
  10. Ceragenin-coated non-spherical gold nanoparticles as novel candidacidal agents
    Authors:
    Skłodowski K, Chmielewska SJ, Depciuch J, Deptuła P, Piktel E, Daniluk T, Zakrzewska M, Czarnowski M, Ciesluk M, Durnaś B, Parlińska-Wojtan M, Savage PB, Bucki R
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 21pp, Article ID 1940), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13111940 - link to the publication
  11. New β-Lactam antibiotics and ceragenins – a study to assess their potential in treatment of infections caused by multidrug-resistant strains of Pseudomonas aeruginosa
    Authors:
    Paprocka P, Durnaś B, Mańkowska A, Skłodowski K, Król G, Zakrzewska M, Czarnowski M, Kot P, Fortunka K, Góźdź S, Savage PB, Bucki R
    Academic press:
    Infection and Drug Resistance (rok: 2021, tom: 14, strony: 5681-5698), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IDR.S338827 - link to the publication
  12. ROS-mediated apoptosis and autophagy in ovarian cancer cells treated with peanut-shaped gold nanoparticles
    Authors:
    Piktel E, Ościłowska I, Suprewicz Ł, Depciuch J, Marcińczyk N, Chabielska E, Wolak P, Wollny T, Janion M, Parlinska-Wojtan M, Bucki R
    Academic press:
    International Journal of Nanomedicine (rok: 2021, tom: 16, strony: 1993-2001), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S277014 - link to the publication
  13. Physics comes to the aid of medicine—clinically- relevant microorganisms through the eyes of atomic force microscope
    Authors:
    Cieśluk M, Deptuła P, Piktel E, Fiedoruk K, Suprewicz Ł, Paprocka P, Kot P, Pogoda K, Bucki R
    Academic press:
    Pathogens (rok: 2020, tom: 9, strony: 969), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens9110969 - link to the publication
  14. Targeting the gut microbiota to relieve the symptoms of irritable bowel syndrome
    Authors:
    Wollny T, Daniluk T, Piktel E, Wnorowska U, Bukłaha A, Głuszek K, Durnaś B, Bucki R
    Academic press:
    Pathogens (rok: 2021, tom: 10, strony: 16pp, Article ID 1545), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens10121545 - link to the publication
  15. Bactericidal properties of rod-, peanut-, and star-shaped gold nanoparticles coated with ceragenin CSA-131 against multidrug-resistant bacterial strains
    Authors:
    Chmielewska SJ, Skłodowski K, Depciuch J, Deptuła P, Piktel E, Fiedoruk K, Kot P, Paprocka P, Fortunka K, Wollny T, Wolak P, Parlińska-Wojtan M, Savage PB, Bucki R
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 27pp, Article ID 425), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13030425 - link to the publication
  16. Targeting bacteria causing otitis media using nanosystems containing nonspherical gold nanoparticles and ceragenins
    Authors:
    Prasad SV, Piktel E, Depciuch J, Maximenko A, Suprewicz Ł, Daniluk T, Spałek J, Wnorowska U, Zieliński PM, Parlińska-Wojtan M, Savage PB, Okła S, Fieodruk K, Bucki R
    Academic press:
    Nanomedicine (rok: 2021, tom: 16, strony: 2657-2678), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/nnm-2021-0370 - link to the publication
  17. Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response
    Authors:
    Suprewicz Ł, Szczepanski A, lenart M, Piktel E, Fiedoruk K, Barreto-Duran E, Kula-Pacurar A, Savage PB, Milewska A, Bucki R, Pyrć K
    Academic press:
    Antiviral Research (rok: 2023, tom: 217, strony: 12pp), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.antiviral.2023.105676 - link to the publication
  1. Antimicrobial activity of gold nanoparticles coated with ceragenin CSA-13 against highly-virulent and antibiotic-resistant Acinetobacter baumannii
    Authors:
    Skłodowski K, Chmielewska S, Suprewicz Ł, Wollny T, Król G, Depciuch J, Parlińska-Wojtan M, Savage PB, Bucki R
    Conference:
    40TH Annual Meeting of the European Society for Paediatric Infectious Diseases. Athens & Online (rok: 2022, ), Wydawca: ESPID and ESPID Fundation
    Data:
    konferencja 9-13.05.2022
    Status:
    Published
  2. Aktywność przeciwbakteryjna ceragenin może być regulowana stężeniem jonów wodorowych
    Authors:
    Wnorowska U, Daniluk T, Durnaś B, Piktel E, Savage PB, Bucki R
    Conference:
    XXIX Ogólnopolski Zjazd Polskiego Towarzystwa Mikrobiologów (rok: 2022, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 15-17.09.2022
    Status:
    Published
  3. Kompleksy inkluzyjne ceragenin z cyklodekstryną jako nowe nanoantybiotyki
    Authors:
    Piktel E, Depciuch J, Daniluk T, Savage PB, Parlińska-Wojtan M, Bucki R
    Conference:
    XXIX Ogólnopolski Zjazd Polskiego Towarzystwa Mikrobiologów (rok: 2022, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 15-17.09.2022
    Status:
    Published

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